Trends and Opportunities in Enzyme Biosensors Coupled to Metal-Organic Frameworks (MOFs): An Advanced Bibliometric Analysis

Round 1

Reviewer 1 Report

Sales et al.  Reviewed on the “Trends and Opportunities in Enzyme Biosensors Coupled to Metal-Organic Frameworks (MOFs): An Advanced Bibliometric Analysis.” The content of the work is interesting, but the manuscript cannot be published in the present form due to the following issues:

1.      A lot of reviews are available on the same  For Eg.:- https://www.mdpi.com/2673-3293/3/1/6 , https://www.mdpi.com/2227-9040/10/10/412 etc. Therefore respond the following quarries:-

a)      What is the main question addressed by the research?

b)      Do author consider the topic original or relevant in the field, and if
so, why?

 

2.      The section 2 Methodology is divided in two parts but the authors made the same subsection numbers as 2.1. Please rectify it

3.      Rectify the careless stuff 3.1.1. The distribution by country and institution, 3.1.4 The most cited articles, 3.1.1. The research areas, 2. Trendy Research Topics 4.1 Quantitative analysis of frequent keywords, 4.1 Research Areas, 4.2.1 Research fields, 4.2.2 Emerging trends, 4.2.3 Two Key Insights

 

4.      Grammar and lots of typological error such as subscripts, superscripts etc. is present in the present form of manuscript. So need an extensive rectification 

Author Response

Sales et al.  Reviewed on the “Trends and Opportunities in Etnzyme Biosensors Coupled to Metal-Organic Frameworks (MOFs): An Advanced Bibliometric Analysis.” The content of the work is interesting, but the manuscript cannot be published in the present form due to the following issues:

1. A lot of reviews are available on the same  For Eg.:- https://www.mdpi.com/2673-3293/3/1/6 , https://www.mdpi.com/2227-9040/10/10/412 etc. Therefore respond the following quarries:-
2. a)      What is the main question addressed by the research?

The main approach taken is to look at trends in enzymes as biosensors coupled to Metal-Organic Frameworks (MOFs). From a structuring and manipulation of the data in a format that encompasses more themes it is possible to perform a more in-depth study. What differentiates and enhances the content of this article is the advanced bibliometric review methodology described in the body of the text. Thus, it is possible to more accurately identify both comprehensive and in-depth aspects in this research area.

1. b)      Do author consider the topic original or relevant in the field, and if
   so, why?

Although there are studies exploring this area, the approach of this paper proves to be extremely useful, because as described in the paper, the advanced bibliometric review method shows several results that can only be obtained with computational processing. This makes this paper original and with a high level of importance in the field.

2. The section 2 Methodology is divided in two parts but the authors made the same subsection numbers as 2.1. Please rectify it

Thank you for your comments and contributions. All suggestions were incorporated into the new version of the manuscript. Changes are in the revised manuscript.

3. Rectify the careless stuff 3.1.1. The distribution by country and institution, 3.1.4 The most cited articles, 3.1.1. The research areas, 2. Trendy Research Topics 4.1 Quantitative analysis of frequent keywords, 4.1 Research Areas, 4.2.1 Research fields, 4.2.2 Emerging trends, 4.2.3 Two Key Insights

Thank you for your comments and contributions. All suggestions were incorporated into the new version of the manuscript. Changes are in the revised manuscript.

4. Grammar and lots of typological error such as subscripts, superscripts etc. is present in the present form of manuscript. So need an extensive rectification 

Thank you for your comments and contributions. All suggestions were incorporated into the new version of the manuscript. Changes are in the revised manuscript.

Author Response File: Author Response.pdf

Reviewer 2 Report

This review presents a bibliometric analysis of MOF-based biosensors. The authors beautifully categorized various aspects of the MOF-based sensors based on data analysis. The review would be useful for those who seek information regarding trends and key focuses in MOF-based research. Please address the following concerns before publishing in Electrochem.

1)      Please correct the column Table. 3 under the column Year published.

2)      Please remove unwanted abbreviations throughout the text. For eg, the phrase “metal-organic frameworks (MOFs)” is repeated throughout the text.

3)      POC sensors are now getting much attention and many POC devices are reported with MOFs. Please elaborate on the search criteria by including POC devices.

4)      In the conclusions section authors highlighted all the advantages of the present bibliometric data analysis. Are there any limitations to the proposed bibliometric data analysis that require attention?

Author Response

This review presents a bibliometric analysis of MOF-based biosensors. The authors beautifully categorized various aspects of the MOF-based sensors based on data analysis. The review would be useful for those who seek information regarding trends and key focuses in MOF-based research. Please address the following concerns before publishing in Electrochem.

1)      Please correct the column Table. 3 under the column Year published.

Thank you for your comments and contributions. All suggestions were incorporated into the new version of the manuscript. Changes are in the revised manuscript.

2)      Please remove unwanted abbreviations throughout the text. For eg, the phrase “metal-organic frameworks (MOFs)” is repeated throughout the text.

Thank you for your comments and contributions. All suggestions were incorporated into the new version of the manuscript. Changes are in the revised manuscript.

3)      POC sensors are now getting much attention and many POC devices are reported with MOFs. Please elaborate on the search criteria by including POC devices.

Thank you for your comments and contributions. All suggestions were incorporated into the new version of the manuscript. Changes are in the revised manuscript.

4)      In the conclusions section authors highlighted all the advantages of the present bibliometric data analysis. Are there any limitations to the proposed bibliometric data analysis that require attention?

As informed in the introduction section, this type of advanced review has limitations regarding its data manipulation, because even with computer processing some information will not be obtained, such as a substantial characteristic of a certain field. Therefore, to try to minimize the impact of this problem, the study also involves a manual investigation of papers for a better understanding. As the data is searched through keywords and logical operators, the result is susceptible to the capture of articles that may end up not having as their main focus the theme under analysis. This requires a research construction strategy to obtain the best possible result and make it possible to develop a work with high accuracy.

Author Response File: Author Response.pdf

Reviewer 3 Report

I have had the opportunity to review the manuscript entitled "Trends and Opportunities in Enzyme Biosensors Coupled to Metal-Organic Frameworks (MOFs): An Advanced Bibliometric Analysis". The review article provides an insightful and comprehensive overview of the research field related to the use of Metal-Organic Frameworks (MOFs) as enzyme-coupled materials in biosensor construction. The authors have conducted an extensive bibliometric analysis of the research published in this field and have identified the most prominent applications and trends for future directions.

 

The analysis presented in the paper is well-structured, and the authors have effectively used three different databases to collect a comprehensive dataset. The paper provides valuable insights into the countries that have published the most in this field and highlights the emergence of China as a significant contributor to research in this area. The authors have also included the computational processing of trend analysis and geocoding, which is a valuable tool for identifying research hotspots and trends. The conclusion provided insights into the current direction of scientific research and potential areas of future interest for researchers worldwide.

 

Overall, the review article makes a significant contribution to the field and is well-suited for publication in "electrochem". However, the following suggestions are recommended to further enhance the manuscript's quality.

 

1)      I recommend that the authors should consider providing additional details on the specific applications of MOF-derived biosensors and how they compare to currently used traditional biosensors.

2)      Author should ensure that the fonts used in the whole manuscript are consistent with the letter size and style of the fonts used in the referenced images, such as Figures 4, 7, 8, and 11. 

 

 

Author Response

Comments and Suggestions for Authors

I have had the opportunity to review the manuscript entitled "Trends and Opportunities in Enzyme Biosensors Coupled to Metal-Organic Frameworks (MOFs): An Advanced Bibliometric Analysis". The review article provides an insightful and comprehensive overview of the research field related to the use of Metal-Organic Frameworks (MOFs) as enzyme-coupled materials in biosensor construction. The authors have conducted an extensive bibliometric analysis of the research published in this field and have identified the most prominent applications and trends for future directions.

The analysis presented in the paper is well-structured, and the authors have effectively used three different databases to collect a comprehensive dataset. The paper provides valuable insights into the countries that have published the most in this field and highlights the emergence of China as a significant contributor to research in this area. The authors have also included the computational processing of trend analysis and geocoding, which is a valuable tool for identifying research hotspots and trends. The conclusion provided insights into the current direction of scientific research and potential areas of future interest for researchers worldwide.

Overall, the review article makes a significant contribution to the field and is well-suited for publication in "electrochem". However, the following suggestions are recommended to further enhance the manuscript's quality.

 

1)      I recommend that the authors should consider providing additional details on the specific applications of MOF-derived biosensors and how they compare to currently used traditional biosensors.

Thank you for your comments and contributions. All suggestions were incorporated into the new version of the manuscript. Changes are in the revised manuscript.

2)      Author should ensure that the fonts used in the whole manuscript are consistent with the letter size and style of the fonts used in the referenced images, such as Figures 4, 7, 8, and 11. 

Thank you for your comments and contributions. All suggestions were incorporated into the new version of the manuscript. Changes are in the revised manuscript.

 

Author Response File: Author Response.pdf

Round 2

Reviewer 1 Report

The authors have made the following changes according to the reviewer's response. Therefore now, the manuscript in its present form can be accepted.