The Era of Genomic Research for Lymphoma: Looking Back and Forward
Abstract
:1. Introduction
2. Gene Expression Profiling (GEP) Analysis
2.1. Diffuse Large B-Cell Lymphomas (DLBCLs)
2.2. Other B-Cell Lymphomas
2.3. Follicular Lymphoma (FL) and Transformed FL (t-FL)
2.4. Peripheral T-Cell Lymphoma (PTCL)
3. Global Genetic Analysis
3.1. The Study of Genomic Copy Number Abnormalities (gCNAs)
3.2. Mutation Analysis: Example on DLBCL
3.3. Mutation and gCNA Analyses: Peripheral T-Cell Lymphoma
3.4. Cooperativity of Genetic Alterations
4. The Integration of Multiomics Data
5. The Tumor Microenvironment
6. A New Diagnostic Platform
7. Perspectives
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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Chapuy B. et al. Nat. Med. 2018 | Schmitz R. et al. NEJM. 2018 | COO Classification | Prognosis | Genetic Characteristics |
---|---|---|---|---|
Cluster 1 | BN2 | ABC or ABC + UC | F | BCL6 rearrangement; Notch pathway: Notch 2, SPEN, DTX1; NF-κB: A20, TNIP1, BCL10, PKCB; immune escape CD70, FAS, PDLI/L2 |
Cluster 2 | N/C | Mixed | UF | TP53 biallelic abnormalities; CDKN2A/RB loss; miR17-92 gain; MCL1 gain |
Cluster 3 | EZB | GCB | UF | BCL2 translocation, EZH2 mutation, cRel amplification, TNFRSF14 alteration, MEF2B, and common chromatin modifier mutation: MLL2, CREBBP, EP300; SIPR2 pathway; STAT6; mTOR; MiR17-92; PTEN |
Cluster 4 | N/C | GCB | F | Histone core and linkers; immune evasion; GNA13, RHOA, SGK1; NF-κB; BRAF/STAT3 |
Cluster 5 | MCD | ABC | UF | MYD88L265P, CD79B; 18p gain, PRDMI, CDKN2A, ETV6, BTG1/2, TBL1XR1; PIM1; immune editing, high cAID |
N/C | N1 | ABC | UF | NOTCH1 mutation; IRF4, 1D3, BCOR, A20; plasmacytic phenotype |
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Chan, W.C.; Iqbal, J. The Era of Genomic Research for Lymphoma: Looking Back and Forward. Hemato 2022, 3, 485-507. https://doi.org/10.3390/hemato3030034
Chan WC, Iqbal J. The Era of Genomic Research for Lymphoma: Looking Back and Forward. Hemato. 2022; 3(3):485-507. https://doi.org/10.3390/hemato3030034
Chicago/Turabian StyleChan, Wing C., and Javeed Iqbal. 2022. "The Era of Genomic Research for Lymphoma: Looking Back and Forward" Hemato 3, no. 3: 485-507. https://doi.org/10.3390/hemato3030034