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10.3390/oral5020025
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Conference Report

ONJ (MRONJ) Update 2024: Osteonecrosis of the Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment—A National Italian Symposium

by
Vittorio Fusco
1,2,
Martina Coppini
3,*,
Gaetano La Mantia
3,
Paolo G. Arduino
4,
Fortunato Buttacavoli
3,
Alessio Gambino
4,
Francesco M. Erovigni
4,
Alberto Bedogni
5,6 and
Giuseppina Campisi
3,7
1
Translational Medicine Unit, DAIRI Department of Integration, Research and Innovation, Azienda Ospedaliera-Universitaria “SS Antonio E Biagio e Cesare Arrigo”, 15121 Alessandria, Italy
2
Oncology Unit, Department of Medicine, Azienda Ospedaliera-Universitaria “SS Antonio E Biagio e Cesare Arrigo”, 15121 Alessandria, Italy
3
Unit of Oral Medicine and Dentistry for Fragile Patients, Department of Rehabilitation, Fragility, and Continuity of Care, University Hospital Palermo, 90127 Palermo, Italy
4
Unit of Oral Rehabilitation, Maxillo-Facial Prosthodontics and Dental Implantology, Department of Surgical Science, CIR Dental School, 10126 Turin, Italy
5
Regional Center for Prevention, Diagnosis and Treatment of Medication and Radiation-Related Bone Diseases of the Head and Neck, University of Padua, 35128 Padua, Italy
6
Department of Neurosciences (DNS), University of Padua, 35128 Padua, Italy
7
Department of Biomedicine, Neuroscience and Advanced Diagnostics (BIND), University of Palermo, 90127 Palermo, Italy
*
Author to whom correspondence should be addressed.
Oral 2025, 5(2), 25; https://doi.org/10.3390/oral5020025
Submission received: 15 December 2024 / Revised: 1 March 2025 / Accepted: 25 March 2025 / Published: 3 April 2025
Versions Notes

Abstract

On 24 February 2024, Italian physicians, dentists and oral care specialists, students, nurses, psychologists, dental hygienists, and other professionals met (live or online) to discuss controversial issues about medication-related osteonecrosis of the jaw (MRONJ). One section hosted international experts who gave lectures about MRONJ experiences in North America, Europe, and Italy. A second section summarized the principal points of an Italian MRONJ position paper published in February 2024 by experts from the Italian Societies of Oral Pathology and Medicine (SIPMO) and Maxillofacial Surgery (SICMF). The following section collates expert opinions about open issues and required fields of research: different definitions of MRONJ and impact on staging; the assessment of individual MRONJ risk before the start of antiresorptive therapy; surgery and implantology in patients at risk for MRONJ; cancer patients without metastases and prevention of cancer-treatment-induced bone Loss (CTIBL); the role of dental hygiene professionals; combined (medical and surgical) and surgical therapy for MRONJ in-patients and out-patients; and legal aspects and claims related to MRONJ diagnosis and treatment. Scientific contributions from hospitals and universities all over Italy were presented in specific sessions (epidemiology; case series; special case reports; prevention experiences; MRONJ treatment). Conclusions: the conference confirmed the importance of the adequate imaging study of bone in the diagnosis and staging of MRONJ cases, the role of surgery in MRONJ treatment, and the value of oral hygiene in the MRONJ prevention.
Keywords: osteonecrosis; jaw; jaws; osteonecrosis of jaw; bisphosphonate; denosumab; ONJ; BRONJ; MRONJ; staging osteonecrosis; jaw; jaws; osteonecrosis of jaw; bisphosphonate; denosumab; ONJ; BRONJ; MRONJ; staging

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MDPI and ACS Style

Fusco, V.; Coppini, M.; La Mantia, G.; Arduino, P.G.; Buttacavoli, F.; Gambino, A.; Erovigni, F.M.; Bedogni, A.; Campisi, G. ONJ (MRONJ) Update 2024: Osteonecrosis of the Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment—A National Italian Symposium. Oral 2025, 5, 25. https://doi.org/10.3390/oral5020025

AMA Style

Fusco V, Coppini M, La Mantia G, Arduino PG, Buttacavoli F, Gambino A, Erovigni FM, Bedogni A, Campisi G. ONJ (MRONJ) Update 2024: Osteonecrosis of the Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment—A National Italian Symposium. Oral. 2025; 5(2):25. https://doi.org/10.3390/oral5020025

Chicago/Turabian Style

Fusco, Vittorio, Martina Coppini, Gaetano La Mantia, Paolo G. Arduino, Fortunato Buttacavoli, Alessio Gambino, Francesco M. Erovigni, Alberto Bedogni, and Giuseppina Campisi. 2025. "ONJ (MRONJ) Update 2024: Osteonecrosis of the Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment—A National Italian Symposium" Oral 5, no. 2: 25. https://doi.org/10.3390/oral5020025

APA Style

Fusco, V., Coppini, M., La Mantia, G., Arduino, P. G., Buttacavoli, F., Gambino, A., Erovigni, F. M., Bedogni, A., & Campisi, G. (2025). ONJ (MRONJ) Update 2024: Osteonecrosis of the Jaw Related to Bisphosphonates and Other Drugs—Prevention, Diagnosis, Pharmacovigilance, Treatment—A National Italian Symposium. Oral, 5(2), 25. https://doi.org/10.3390/oral5020025

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