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Compounds, Volume 5, Issue 1 (March 2025) – 2 articles

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27 pages, 1240 KiB  
Review
Therapeutic Capabilities of Triterpenes and Triterpenoids in Immune and Inflammatory Processes: A Review
by Martha Mantiniotou, Vassilis Athanasiadis, Dimitrios Kalompatsios, Eleni Bozinou and Stavros I. Lalas
Compounds 2025, 5(1), 2; https://doi.org/10.3390/compounds5010002 - 3 Jan 2025
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Abstract
Plant-derived secondary metabolites such as triterpenes and triterpenoids are present in a wide range of plant species. These compounds are particularly attractive due to their extensive range of biological properties and potential applications as intermediates in the synthesis of novel pharmacologically promising medications. [...] Read more.
Plant-derived secondary metabolites such as triterpenes and triterpenoids are present in a wide range of plant species. These compounds are particularly attractive due to their extensive range of biological properties and potential applications as intermediates in the synthesis of novel pharmacologically promising medications. Saponins, which are glycosylated triterpenoids found in nature, exhibit the same properties. At this point, the effectiveness of saponins as an anti-inflammatory medication has been verified. This review article examines the primary connections between immune responses and anti-inflammatory activity, focusing specifically on the correlation between triterpenes and triterpenoids. These connections have been investigated in various cell models, as well as in vitro and in vivo studies. The present research provides a comprehensive overview of the current understanding of the therapeutic capabilities of triterpenes and triterpenoids in immune and inflammatory processes. It also highlights emerging standards and their potential utilization in pharmaceutical and clinical settings. Full article
(This article belongs to the Special Issue Organic Compounds with Biological Activity)
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28 pages, 1833 KiB  
Review
A Review on Metal–Organic Frameworks as Technological Excipients: Synthesis, Characterization, Toxicity, and Application in Drug Delivery Systems
by Pedrita A. Sampaio, Emanuella C. V. Pereira, Pedro G. S. Sá, José Marcos T. Alencar Filho, Leslie R. M. Ferraz, Rodolfo H. V. Nishimura, Aline S. Ferreira, Pedro J. Rolim Neto, Evando S. Araújo and Larissa A. Rolim
Compounds 2025, 5(1), 1; https://doi.org/10.3390/compounds5010001 - 2 Jan 2025
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Abstract
Metal–organic frameworks (MOFs) are also known as porous coordination polymers. This kind of material is constructed with inorganic nodes (metal ions or clusters) with organic linkers and has emerged as a promising class of materials with several unique properties. Well-known applications of MOFs [...] Read more.
Metal–organic frameworks (MOFs) are also known as porous coordination polymers. This kind of material is constructed with inorganic nodes (metal ions or clusters) with organic linkers and has emerged as a promising class of materials with several unique properties. Well-known applications of MOFs include their use as gas storage and in separation, catalysis, carbon dioxide capture, sensing, slender film gadgets, photodynamic therapy, malignancy biomarkers, treatment, and biomedical imaging. Over the past 15 years, an increasing amount of research has been directed to MOFs due to their advanced applications in fuel cells, supercapacitors, catalytic conversions, and drug delivery systems. Various synthesis methods have been proposed to achieve MOFs with nanometric size and increased surface area, controlled surface topology, and chemical activity for industrial use. In this context, the pharmaceutical industry has been watching the accelerated development of these materials with great attention. Thus, the objective of this work is to study the synthesis, characterization, and toxicity of MOFs as potential technological excipients for the development of drug carriers. This work highlights the use of MOFs not only as delivery systems (DDSs) but also in advanced diagnostics and therapies, such as photodynamic therapy and targeted delivery to tumors. Bibliometric analyses showed a growing interest in the topic, emphasizing its contemporary relevance. Full article
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