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Entry

Displacement Micropump with Check Valves for Diabetes Care—The Challenge of Pumping Insulin at Negative Pressure

by
Eric Chappel
1,2
1
Debiotech SA, Microsystems Department, 1004 Lausanne, Switzerland
2
Haute École du Paysage, D’ingénierie et D’architecture (HEPIA), HES-SO University of Applied Sciences and Arts Western Switzerland, 1202 Geneva, Switzerland
Encyclopedia 2024, 4(2), 818-835; https://doi.org/10.3390/encyclopedia4020052
Submission received: 12 April 2024 / Revised: 29 April 2024 / Accepted: 9 May 2024 / Published: 13 May 2024
(This article belongs to the Section Medicine & Pharmacology)
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Definition

The displacement micropump with passive check valves is an attractive solution for precise insulin infusion in patients with type I diabetes. Unlike most insulin pumps that push insulin from a cartridge using a piston, a displacement micropump will first pull insulin from the reservoir before infusing it into the patient. This dual sequence introduces new challenges in terms of insulin stability, notably if the reservoir is not pressurized. After an introduction to displacement micropumps and a brief review of the insulin degradation mechanism, micropump design rules are discussed in light of microfluidic theory.
Keywords: MEMS micropump; displacement pump; check valves; pump failure mode; insulin delivery; diabetes care MEMS micropump; displacement pump; check valves; pump failure mode; insulin delivery; diabetes care

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MDPI and ACS Style

Chappel, E. Displacement Micropump with Check Valves for Diabetes Care—The Challenge of Pumping Insulin at Negative Pressure. Encyclopedia 2024, 4, 818-835. https://doi.org/10.3390/encyclopedia4020052

AMA Style

Chappel E. Displacement Micropump with Check Valves for Diabetes Care—The Challenge of Pumping Insulin at Negative Pressure. Encyclopedia. 2024; 4(2):818-835. https://doi.org/10.3390/encyclopedia4020052

Chicago/Turabian Style

Chappel, Eric. 2024. "Displacement Micropump with Check Valves for Diabetes Care—The Challenge of Pumping Insulin at Negative Pressure" Encyclopedia 4, no. 2: 818-835. https://doi.org/10.3390/encyclopedia4020052

APA Style

Chappel, E. (2024). Displacement Micropump with Check Valves for Diabetes Care—The Challenge of Pumping Insulin at Negative Pressure. Encyclopedia, 4(2), 818-835. https://doi.org/10.3390/encyclopedia4020052

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