Clustering Diseases in Cancer and Health Organization: What Is the Gold-Standard Approach?
Xiaoxiao Sun
Round 1
Reviewer 1 Report
Minor comments:
Page 1; Line 41: condition. oncological.
Page 2; Line 48: PubMed and remove the underscore.
Page 2; Line 49: (P.C. and T.C.)
Page 2; Line 68: Although there is a strong association... Can you provide some references?
Page 2; Line 74: Could you explain what the homogeneous standardized methods are?
Page 3; Line 144: organization. of the health system.
Page 4; Line 170: health system same.
Page 4; Line 182: co-morbidities
Page 5; Line 197: toxic agents. for the organism.
Page 5; Line 201: randomized...
Page 5; Line 246: polytherapy's
Page 9; Line 343: Always...
Page 9; Line 353: You may need to rewrite this part.
Page 9; Line 363: It seems that you just need 3.11.1. and 3.11.2.
Page 9; Line 365: comorbidities. multiple
Figure 1: chronic...(COPD).
Page 10; Figure 3: Comorbidities; COVID-19
Page 14: Author contributions???
Author Response
Dear Editor in Chief
Please I sent you in attachment a revised manuscript entitled - CLUSTERING DISEASES IN CANCER AND HEALTH ORGANIZATION: What is the gold-standard approach? We thank the Editorial Office and Reviewers for your crucial comments.
REVIEWER 1
- According to the suggestion of the reviewer, page1, line 41 has been modified
- According to the suggestion of the reviewer, page 2, line 48 has been modified
- According to the suggestion of the reviewer, page 2, line 49 has been modified
- According to the suggestion of the reviewer, page 2, line 68, two references have been added
- According to the suggestion of the reviewer, page 2, line 74, two references have been added
- According to the suggestion of the reviewer, page 3, line 144 has been modified
- According to the suggestion of the reviewer, page 4, line 170 has been modified
- According to the suggestion of the reviewer, page 4, line 182 has been modified
- According to the suggestion of the reviewer, page 5, line 197 has been modified
- According to the suggestion of the reviewer, page 5, line 201 has been modified
- According to the suggestion of the reviewer, page 5, line 246 has been modified
- According to the suggestion of the reviewer, page 9, line 353 has been modified
- According to the suggestion of the reviewer, page 9, line 363 has been modified
- According to the suggestion of the reviewer, page 9, line 365 has been modified
- According to the suggestion of the reviewer, figure 1 has been modified
- According to the suggestion of the reviewer, figure 3 has been modified
- According to the suggestion of the reviewer Author’s contribution has been added
Reviewer 2 Report
This manuscript deals with a very interesting and important aspect of optimization of the care of the cancer patient with clustering diseases. However, there are several fundamental faults with the text in the manuscript that need to be addressed.
- The authors have failed to establish the theme of the manuscript. The major focus of the manuscript is the gold-standard approach, which should be discussed in the manuscript to emphasize the approaches.
- Line 30-31: Why cancer is more prevalent in aged people? Give a proper justification with references?
- Line 31-35: Repetition of abstract, better to rephrase or delete to avoid repetition.
- Line 41: Authors have put ‘full stop’ irrespectively at many places. It is advised to go through the entire manuscript for such typo.
5. Throughout the manuscript, the authors have cited a small number of recent studies like some publications of the mentioned duration are missing that are part of PubMed search. For example-
https://doi.org/10.1155/2015/259341
https://doi.org/10.1111/ajco.12677
- Line 89 to 92: It would be better to list out some other risk factors, and specify them that are not strongly (or even inversely) associated with the breast cancer and prostate cancer with appropriate supporting evidence, if any.
77. In the heading ‘future directions’ the sub-heading ‘key messages’ does not indicate the importance of preventive points addressed below it, that should be replaced with some more relevant term (Preventive measures for clustering disease). It is also advised to add a separate heading mentioning the limitations with comorbidity in cancers.
88. It would be better to add a table mentioning the type of comorbidities and preventive approaches used in various cancers.
99. The manuscript's conclusion reads more like a foregone conclusion than a sum up of the manuscript’s most crucial components. It also lacked details regarding the positive approaches that will help in making the life of cancer patients with comorbidities less struggling.
10. The manuscript has the flaw of not mentioning the source (citations) for the majority of the statements.
Author Response
Dear Editor in Chief
Please I sent you in attachment a revised manuscript entitled - CLUSTERING DISEASES IN CANCER AND HEALTH ORGANIZATION: What is the gold-standard approach? We thank the Editorial Office and Reviewers for your crucial comments.
REVIEWER 1
- According to the suggestion of the reviewer, page1, line 41 has been modified
- According to the suggestion of the reviewer, page 2, line 48 has been modified
- According to the suggestion of the reviewer, page 2, line 49 has been modified
- According to the suggestion of the reviewer, page 2, line 68, two references have been added
- According to the suggestion of the reviewer, page 2, line 74, two references have been added
- According to the suggestion of the reviewer, page 3, line 144 has been modified
- According to the suggestion of the reviewer, page 4, line 170 has been modified
- According to the suggestion of the reviewer, page 4, line 182 has been modified
- According to the suggestion of the reviewer, page 5, line 197 has been modified
- According to the suggestion of the reviewer, page 5, line 201 has been modified
- According to the suggestion of the reviewer, page 5, line 246 has been modified
- According to the suggestion of the reviewer, page 9, line 353 has been modified
- According to the suggestion of the reviewer, page 9, line 363 has been modified
- According to the suggestion of the reviewer, page 9, line 365 has been modified
- According to the suggestion of the reviewer, figure 1 has been modified
- According to the suggestion of the reviewer, figure 3 has been modified
- According to the suggestion of the reviewer Author’s contribution has been added
Round 2
Reviewer 2 Report
The present MS is substantially improved now. I, therefore recommend the MS for publication.
