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Volume 3
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10.3390/oxygen3030022
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Review

The Ion Channels Involved in Oxidative Stress-Related Gastrointestinal Diseases

by
Maria Rosaria Miranda
1,2,
Vincenzo Vestuto
1,*,
Ornella Moltedo
1,
Michele Manfra
3,
Pietro Campiglia
1,4 and
Giacomo Pepe
1,*
1
Department of Pharmacy, University of Salerno, Via G. Paolo II, Fisciano, 84084 Salerno, Italy
2
PhD Program in Drug Discovery and Development, University of Salerno, Fisciano, 84084 Salerno, Italy
3
Department of Science, University of Basilicata, Viale dell’Ateneo Lucano 10, 85100 Potenza, Italy
4
NBFC, National Biodiversity Future Center, 90133 Palermo, Italy
*
Authors to whom correspondence should be addressed.
Oxygen 2023, 3(3), 336-365; https://doi.org/10.3390/oxygen3030022
Submission received: 19 June 2023 / Revised: 29 July 2023 / Accepted: 4 August 2023 / Published: 21 August 2023
(This article belongs to the Special Issue Feature Papers in Oxygen Volume Ⅱ)
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Abstract

The pathogenesis of various gastrointestinal (GI) disorders, including gastritis, ulcers, inflammatory bowel disease (IBD) and cancer, can be linked to oxidative stress. It is known that reactive species carry out a crucial role in the genesis and progression of these pathologies; however, the contribution of ionic channels in their development is still under discussion. The function of ion channels in the gastrointestinal tract influences a variety of cellular processes. Acid-base balance, mucus layer, microbiota and mucosal blood flow are only some of the essential features for maintaining the mucosal integrity of the cellular barrier in the intestine, allowing for the preservation of proper permeability and ensuring tissue homeostasis. As the functional modulation of several ion channels is altered during oxidative stress conditions associated with gastrointestinal inflammation, this review focuses on contributing new insight into the roles of and the relationship between ion channels and oxidative stress in GI diseases. The association between ion channels and oxidative stress conditions could be used in diagnostics and the development of new pharmacological treatments for major gastrointestinal diseases.
Keywords: ion channels; oxidative stress; reactive species; antioxidants; gastrointestinal diseases ion channels; oxidative stress; reactive species; antioxidants; gastrointestinal diseases

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MDPI and ACS Style

Miranda, M.R.; Vestuto, V.; Moltedo, O.; Manfra, M.; Campiglia, P.; Pepe, G. The Ion Channels Involved in Oxidative Stress-Related Gastrointestinal Diseases. Oxygen 2023, 3, 336-365. https://doi.org/10.3390/oxygen3030022

AMA Style

Miranda MR, Vestuto V, Moltedo O, Manfra M, Campiglia P, Pepe G. The Ion Channels Involved in Oxidative Stress-Related Gastrointestinal Diseases. Oxygen. 2023; 3(3):336-365. https://doi.org/10.3390/oxygen3030022

Chicago/Turabian Style

Miranda, Maria Rosaria, Vincenzo Vestuto, Ornella Moltedo, Michele Manfra, Pietro Campiglia, and Giacomo Pepe. 2023. "The Ion Channels Involved in Oxidative Stress-Related Gastrointestinal Diseases" Oxygen 3, no. 3: 336-365. https://doi.org/10.3390/oxygen3030022

APA Style

Miranda, M. R., Vestuto, V., Moltedo, O., Manfra, M., Campiglia, P., & Pepe, G. (2023). The Ion Channels Involved in Oxidative Stress-Related Gastrointestinal Diseases. Oxygen, 3(3), 336-365. https://doi.org/10.3390/oxygen3030022

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