Relationship of Postoperative Serum Neuro-Specific Enolase Levels with Postoperative Delirium Occurring after Microvascular Depression Surgery in Older Patients
Abstract
:1. Introduction
2. Materials and Methods
2.1. Study Design, Setting, and Participants
2.2. Data Source and Variables
2.3. Measurements
2.4. Statistical Methods
3. Results
3.1. Study Population Characteristics
3.2. Serum NSE Levels and Other Variables
3.3. POD Prediction
4. Discussion
5. Conclusions
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
References
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Variable | Range | Number/Median (IQR) | Correlation Analysis | |
---|---|---|---|---|
r-Value | p-Value | |||
Gender (male/female) | 81/128 | 0.048 | 0.490 | |
Age (years) | 65–92 | 73 (67–78) | 0.167 | 0.016 |
Type of diseases | 0.024 | 0.735 | ||
HFS | 102 | |||
TN | 107 | |||
Time from symptoms to treatment (months) | 6–121 | 21 (15–43.5) | 0.027 | 0.693 |
Baseline MMSE score | 24–30 | 29 (27–30) | 0.261 | <0.001 |
Duration of anesthesia (min) | 66–154 | 91 (82–97) | 0.215 | 0.002 |
Hospitalization after surgery (days) | 7–15 | 8 (8–9) | 0.314 | <0.001 |
CRP | 1–71 | 10 (9–16) | 0.157 | 0.023 |
IL-6 | 2.00–325.00 | 28.80 (14.70–62.65) | 0.047 | 0.495 |
TNF-a | 4.00–179.00 | 10.40 (7.00–12.05) | 0.045 | 0.514 |
S100β | 310.00–1138.67 | 529.05 (419.52–600.48) | 0.189 | 0.006 |
HbA1c | 4.4–9.4 | 6.00 (5.50–6.45) | 0.111 | 0.109 |
Type of delirium Hyperactive Hypoactive Mixed MDAS score (0–30) <10 <20 ≤30 | 14 26 6 5 33 8 |
Variable | POD | Non-POD | p-Value | OR (95% CI) | p-Value | OR (95% CI) |
---|---|---|---|---|---|---|
Univariate Regression | Multivariate Regression | |||||
Gender | 0.495 | 0.958 (0.200–4.589) | ||||
Male | 20 | 61 | ||||
Female | 26 | 102 | ||||
Age (years) | 78.5 (76–82) | 70 (67–75) | <0.001 | 1.159 (1.044–1.288) | 0.006 | 1.153 (1.040–1.277) |
Type of disease | 0.620 | 1.286 (0.237–6.975) | ||||
HFS | 24 | 78 | ||||
TN | 22 | 85 | ||||
Time from symptoms to treatment (months) | 20.5 (14.5–45.25) | 21 (15–42) | 0.945 | 1.011 (0.984–1.040) | ||
Baseline MMSE score PND | 26 (25–27) 17(43) | 29 (28–30) 28(134) | <0.001 0.026 | 0.469 (0.289–0.763) 2.475(1.178–5.005) | ||
Duration of anesthesia (min) | 98.5 (93–105.25) | 88 (80–95) | <0.001 | 1.121 (1.022–1.229) | ||
Hospitalization after surgery | 9 (9–10) | 9 (8–9) | <0.001 | 3.620 (1.344–9.751) | ||
HbA1c | 6.00 (5.50–6.43) | 6.00 (5.50–6.50) | 0.848 | 0.791 (0.363–1.722) | ||
CRP | 19 (10.75–34) | 10 (9–13) | <0.001 | 1.143 (1.052–1.241) | ||
IL-6 | 31.95 (19.13–67.35) | 27.30 (12.90–59.60) | 0.133 | 0.993 (0.973–1.014) | ||
TNF-a | 10.80 (7.17–12.42) | 10.40 (7.00–11.70) | 0.218 | 0.955 (0.888–1.026) | ||
S100β | 562.98 (419.52–771.90) | 463.67 (387.00–600.48) | 0.006 | 1.006 (1.000–1.012) | 0.048 | 1.006 (1.000–1.012) |
NSE | 17.80 (16.60–32.30) | 11.20 (7.34–14.90) | <0.001 | 1.357 (1.184–1.554) | <0.001 | 1.326 (1.177–1.494) |
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Guo, T.; Liu, Z.; Qi, J.; Wu, Z. Relationship of Postoperative Serum Neuro-Specific Enolase Levels with Postoperative Delirium Occurring after Microvascular Depression Surgery in Older Patients. J. Vasc. Dis. 2023, 2, 1-12. https://doi.org/10.3390/jvd2010001
Guo T, Liu Z, Qi J, Wu Z. Relationship of Postoperative Serum Neuro-Specific Enolase Levels with Postoperative Delirium Occurring after Microvascular Depression Surgery in Older Patients. Journal of Vascular Diseases. 2023; 2(1):1-12. https://doi.org/10.3390/jvd2010001
Chicago/Turabian StyleGuo, Tengxian, Zhenxing Liu, Ji Qi, and Zhen Wu. 2023. "Relationship of Postoperative Serum Neuro-Specific Enolase Levels with Postoperative Delirium Occurring after Microvascular Depression Surgery in Older Patients" Journal of Vascular Diseases 2, no. 1: 1-12. https://doi.org/10.3390/jvd2010001