Next Article in Journal
Endoconduit: Utilizing the “Pave-and-Crack” Technique to Treat an Abdominal Aortic Aneurysm—A Contemporary Literature Review, and “How We Do It”
Previous Article in Journal
Macrovascular Function in People with HIV After Recent SARS-CoV-2 Infection
 
 
Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
Journals
JVD
Volume 4
Issue 1
10.3390/jvd4010005
jvd-logo
Submit to this Journal Review for this Journal Propose a Special Issue
► Article Menu

Article Menu

share Share announcement Help format_quote Cite question_answer Discuss in SciProfiles
first_page
settings
Order Article Reprints
Font Type:
Arial Georgia Verdana
Font Size:
Aa Aa Aa
Line Spacing:
Column Width:
Background:
Review

Sexual Dimorphism in Abdominal Aortic Aneurysm—Insights from Clinical and Experimental Studies

by
Zain Husain Islam
1,*,
Hongzhang Mei
2,
Zoe Tetz
1,
Rohan Kanchetty
1,
Sophia Stanisic
1,
Nicholas Hoyt
1,
William Aaron Marcum
1,
Campbell Johnston
1,
Eric William Kent
1,
Mengxue Zhang
3,
Nina Islam
1,
Alvin Anand
2,
Kaijie Zhang
1,2,4,
Li Yin
1,2,4 and
Bowen Wang
1,2,*
1
Department of Surgery, School of Medicine, University of Virginia, Charlottesville, VA 22908, USA
2
Department of Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60603, USA
3
Department of Pathology, The University of Chicago Medicine, Chicago, IL 60637, USA
4
Department of Vascular Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310058, China
*
Authors to whom correspondence should be addressed.
J. Vasc. Dis. 2025, 4(1), 5; https://doi.org/10.3390/jvd4010005
Submission received: 23 December 2024 / Revised: 10 January 2025 / Accepted: 26 January 2025 / Published: 31 January 2025
(This article belongs to the Section Peripheral Vascular Diseases)
Versions Notes

Abstract

Abdominal aortic aneurysm (AAA) is a prevalent vascular disease with high mortality rates upon rupture. AAA features a distinct sexual dimorphism, with a prevalence three times higher in males than in females. Interestingly, females are faced with a greater risk of rupture and a worse prognosis following surgical repairs. Nevertheless, stratified approaches for managing and predicting outcomes of AAA in male and female patients remain limited, largely hindered by our incomplete understanding of the mechanisms underlying this sex dimorphism. In this article, we will summarize the recent clinical and preclinical efforts aimed at understanding the therapeutic and mechanistic implications of sex-specific factors shaping AAA.
Keywords: abdominal aortic aneurysm; sexual dimorphism; peripheral vascular disease abdominal aortic aneurysm; sexual dimorphism; peripheral vascular disease

Share and Cite

MDPI and ACS Style

Islam, Z.H.; Mei, H.; Tetz, Z.; Kanchetty, R.; Stanisic, S.; Hoyt, N.; Marcum, W.A.; Johnston, C.; Kent, E.W.; Zhang, M.; et al. Sexual Dimorphism in Abdominal Aortic Aneurysm—Insights from Clinical and Experimental Studies. J. Vasc. Dis. 2025, 4, 5. https://doi.org/10.3390/jvd4010005

AMA Style

Islam ZH, Mei H, Tetz Z, Kanchetty R, Stanisic S, Hoyt N, Marcum WA, Johnston C, Kent EW, Zhang M, et al. Sexual Dimorphism in Abdominal Aortic Aneurysm—Insights from Clinical and Experimental Studies. Journal of Vascular Diseases. 2025; 4(1):5. https://doi.org/10.3390/jvd4010005

Chicago/Turabian Style

Islam, Zain Husain, Hongzhang Mei, Zoe Tetz, Rohan Kanchetty, Sophia Stanisic, Nicholas Hoyt, William Aaron Marcum, Campbell Johnston, Eric William Kent, Mengxue Zhang, and et al. 2025. "Sexual Dimorphism in Abdominal Aortic Aneurysm—Insights from Clinical and Experimental Studies" Journal of Vascular Diseases 4, no. 1: 5. https://doi.org/10.3390/jvd4010005

APA Style

Islam, Z. H., Mei, H., Tetz, Z., Kanchetty, R., Stanisic, S., Hoyt, N., Marcum, W. A., Johnston, C., Kent, E. W., Zhang, M., Islam, N., Anand, A., Zhang, K., Yin, L., & Wang, B. (2025). Sexual Dimorphism in Abdominal Aortic Aneurysm—Insights from Clinical and Experimental Studies. Journal of Vascular Diseases, 4(1), 5. https://doi.org/10.3390/jvd4010005

Article Metrics

Back to TopTop