4-Azatricyclo[5.2.2.02,6]undecane-3,5,8-triones as Potential Pharmacological Agents
Abstract
:Introduction
Results and Discussion
Compound | aCC50 | bEC50 |
---|---|---|
MT-4 | HIV-1 | |
2, 3, 3a, 3b, 3c, 3d, 3f, 3h, 4a, 4b, 4c, 4d, 4e, 4f, 4g, 4h, 5a, 5b, 5c, 5d, 5e, 5f, 5g, 5h, 5i, 5j | >100 | >100 |
Experimental
General
Synthesis of 3,5-dioxo-4-azatricyclo[5.2.2.02,6]undec-8-en-8-yl acetate (1)
Synthesis of 4-azatricyclo[5.2.2.02,6]undecane-3,5,8-trione (2)
General method for preparation of 4-(3-bromopropyl)- and 4-(4-bromobutyl)-4-aza-tricyclo[5.2.2.02,6]undecane-3,5,8-trione (3 and 4)
General method for preparation of 4-substituted arylpiperazines with derivatives 3 and 4 (3a–4h)
Synthesis of 4-(oxiran-2-ylmethyl)-4-azatricyclo[5.2.2.02,6]undecane-3,5,8-trione (5)
General method for preparation of 4-(amino)-2-hydroxypropyl derivatives of 4-aza-tricyclo[5.2.2.02,6]undecane-3,5,8-trione 5a–5j
Biological Assays: Compounds
Cells and Viruses
Cytotoxicity Assays
Acknowledgments
References
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Kossakowski, J.; Bielenica, A.; Mirosław, B.; Kozioł, A.E.; Dybała, I.; Struga, M. 4-Azatricyclo[5.2.2.02,6]undecane-3,5,8-triones as Potential Pharmacological Agents. Molecules 2008, 13, 1570-1583. https://doi.org/10.3390/molecules13081570
Kossakowski J, Bielenica A, Mirosław B, Kozioł AE, Dybała I, Struga M. 4-Azatricyclo[5.2.2.02,6]undecane-3,5,8-triones as Potential Pharmacological Agents. Molecules. 2008; 13(8):1570-1583. https://doi.org/10.3390/molecules13081570
Chicago/Turabian StyleKossakowski, Jerzy, Anna Bielenica, Barbara Mirosław, Anna E. Kozioł, Izabela Dybała, and Marta Struga. 2008. "4-Azatricyclo[5.2.2.02,6]undecane-3,5,8-triones as Potential Pharmacological Agents" Molecules 13, no. 8: 1570-1583. https://doi.org/10.3390/molecules13081570