Werner Syndrome Protein and DNA Replication
Abstract
:1. Introduction
2. WRN in DNA Replication
2.1. Role of WRN in Replication Fork Progression
2.2. Role of WRN in Replication Fork Arrest Recovery
2.3. Role of WRN in Replication Fork Protection
3. WRN and Phosphorylation
3.1. Role of DNA-PKCS-Mediated WRN Phosphorylation
3.2. Role of ATR-Mediated WRN Phosphorylation
3.3. Role of ATM-Mediated WRN Phosphorylation
3.4. Role of CDK1-Mediated WRN Phosphorylation
4. WRN Stability and Degradation
4.1. Role of WRN Ubiquitination
4.2. Role of WRN Acetylation
5. WRN and DSB Repair Pathway Choice
5.1. Role of WRN in Classical NHEJ
5.2. Role of WRN in Alternative NHEJ Pathway
5.3. Role of WRN in HR
6. Consequences of WRN Deficiency and Replication Stress
6.1. Role of WRN in Maintaining Genome Stability
6.2. Role of WRN in Suppressing Premature Aging
7. Conclusions and Future Perspectives
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Mukherjee, S.; Sinha, D.; Bhattacharya, S.; Srinivasan, K.; Abdisalaam, S.; Asaithamby, A. Werner Syndrome Protein and DNA Replication. Int. J. Mol. Sci. 2018, 19, 3442. https://doi.org/10.3390/ijms19113442
Mukherjee S, Sinha D, Bhattacharya S, Srinivasan K, Abdisalaam S, Asaithamby A. Werner Syndrome Protein and DNA Replication. International Journal of Molecular Sciences. 2018; 19(11):3442. https://doi.org/10.3390/ijms19113442
Chicago/Turabian StyleMukherjee, Shibani, Debapriya Sinha, Souparno Bhattacharya, Kalayarasan Srinivasan, Salim Abdisalaam, and Aroumougame Asaithamby. 2018. "Werner Syndrome Protein and DNA Replication" International Journal of Molecular Sciences 19, no. 11: 3442. https://doi.org/10.3390/ijms19113442