The L10P Polymorphism and Serum Levels of Transforming Growth Factor β1 in Human Breast Cancer
Abstract
:1. Introduction
2. Results and Discussion
2.1. The TGFβ1 L10P SNP and Breast Cancer Risk
2.2. Analysis of TGFβ1 Serum Levels
2.3. Discussion
3. Experimental Section
4. Conclusions
Acknowledgments
Conflict of Interest
References
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Total | Leu/Leu | Leu/Pro | Pro/Pro | p-value | ||
---|---|---|---|---|---|---|
All subjects | 526 | 186 (35.4%) | 248 (47.1%) | 92 (17.5%) | ||
Patients | 274 | 99 (36.1%) | 131 (47.8%) | 44 (16.1%) | 0.664 | |
Controls | 252 | 87 (34.5%) | 117 (46.4%) | 48 (19.0%) | ||
Patient subgroups | ||||||
Tumor size | pT1 | 133 | 50 (37.6%) | 62 (46.6%) | 21 (15.8%) | 0.586 |
pT2 | 55 | 20 (36.4%) | 27 (49.1%) | 8 (14.5%) | ||
pT3, pT4 | 12 | 3 (25.0%) | 5 (41.7%) | 4 (33.3%) | ||
other, na | 74 | 26 (35.1%) | 37 (50.0%) | 11 (14.9%) | ||
Tumor type | ductal | 148 | 53 (35.8%) | 71 (48.0%) | 24 (16.2%) | 0.561 |
lobular | 48 | 20 (41.7%) | 23 (47.9%) | 5 (10.4%) | ||
other, na | 78 | 26 (33.3%) | 37 (47.4%) | 15 (19.2%) | ||
Stage | I | 97 | 38 (39.2%) | 40 (41.2%) | 19 (19.6%) | 0.290 |
II | 63 | 22 (34.9%) | 35 (55.6%) | 6 (9.5%) | ||
III | 18 | 5 (27.8%) | 10 (55.6%) | 3 (16.7%) | ||
other, na | 96 | 34 (35.4%) | 46 (47.9%) | 16 (16.7%) | ||
Grade | pG1 | 42 | 17 (40.5%) | 21 (50.0%) | 4 (9.5%) | 0.405 |
pG2 | 115 | 38 (33.0%) | 58 (50.4%) | 19 (16.5%) | ||
pG3 | 88 | 36 (40.9%) | 35 (39.8%) | 17 (19.3%) | ||
na | 29 | 8 (27.6%) | 17 (58.6%) | 4 (13.8%) | ||
Lymph node status | pN0 | 143 | 56 (39.3%) | 62 (43.4%) | 25 (17.5%) | 0.320 |
pN+ | 53 | 18 (34.0%) | 29 (54.7%) | 6 (11.3%) | ||
na | 78 | 25 (32.1%) | 40 (51.3%) | 13 (16.7%) | ||
ER status | pos | 201 | 75 (37.3%) | 100 (49.8%) | 26 (12.9%) | 0.085 |
neg | 61 | 21 (34.4%) | 25 (41.0%) | 15 (24.6%) | ||
na | 12 | 3 (25.0%) | 6 (50.0%) | 3 (25.0%) | ||
PR status | pos | 138 | 47 (34.1%) | 73 (52.9%) | 18 (13.0%) | 0.130 |
neg | 117 | 46 (39.3%) | 48 (41.0%) | 23 (19.7%) | ||
na | 19 | 6 (31.6%) | 10 (52.6%) | 3 (15.8%) | ||
HER2 status | pos | 51 | 24 (47.1%) | 21 (41.2%) | 6 (11.8%) | 0.176 |
neg | 201 | 67 (33.3%) | 99 (49.3%) | 35 (17.4%) | ||
na | 22 | 8 (36.4%) | 11 (50.0%) | 3 (13.6%) | ||
p53 status | pos | 57 | 23 (40.4%) | 22 (38.6%) | 12 (21.1%) | 0.296 |
neg | 190 | 68 (35.8%) | 94 (49.5%) | 28 (14.7%) | ||
na | 27 | 8 (29.6%) | 15 (55.6%) | 4 (14.8%) |
Genotypes/Alleles | OR | 95% c.i. | p-Value |
---|---|---|---|
Pro/Pro vs. Leu/Leu | 0.81 | 0.49–1.33 | 0.409 |
Pro/Pro vs. Leu/Pro | 0.82 | 0.51–1.32 | 0.429 |
Leu/Pro vs. Leu/Leu | 0.98 | 0.67–1.44 | 0.934 |
Pro/Pro + Leu/Pro vs. Leu/Leu | 0.93 | 0.65–1.33 | 0.700 |
Pro/Pro vs. Leu/Pro + Leu/Leu | 0.81 | 0.52–1.28 | 0.368 |
Pro vs. Leu | 0.91 | 0.71–1.16 | 0.455 |
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Taubenschuß, E.; Marton, E.; Mogg, M.; Frech, B.; Ehart, L.; Muin, D.; Schreiber, M. The L10P Polymorphism and Serum Levels of Transforming Growth Factor β1 in Human Breast Cancer. Int. J. Mol. Sci. 2013, 14, 15376-15385. https://doi.org/10.3390/ijms140815376
Taubenschuß E, Marton E, Mogg M, Frech B, Ehart L, Muin D, Schreiber M. The L10P Polymorphism and Serum Levels of Transforming Growth Factor β1 in Human Breast Cancer. International Journal of Molecular Sciences. 2013; 14(8):15376-15385. https://doi.org/10.3390/ijms140815376
Chicago/Turabian StyleTaubenschuß, Eva, Erika Marton, Maurice Mogg, Barbara Frech, Lisa Ehart, Dana Muin, and Martin Schreiber. 2013. "The L10P Polymorphism and Serum Levels of Transforming Growth Factor β1 in Human Breast Cancer" International Journal of Molecular Sciences 14, no. 8: 15376-15385. https://doi.org/10.3390/ijms140815376