Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults
Abstract
:1. Introduction
2. Materials and Methods
2.1. Experimental Design
2.2. Participants
2.3. Visits Overview
2.3.1. Visit 1: Pre-participation screening
2.3.2. Visits 2 and 3
2.4. Laboratory Assessments
2.4.1. Anthropometric Measurements
2.4.2. Blood sampling and analysis
2.4.3. Resting heart rate and blood pressure
2.4.4. Resting Electrocardiogram
2.4.5. Supplementation intervention
2.4.6. Diet Tracking
2.5. Statistical Analysis
3. Results
3.1. Cardiovascular Function
3.2. Blood Biomarkers
3.3. Dietary Tracking
4. Discussion
4.1. Cardiovascular Function
4.2. Blood Biomarkers
5. Conclusions, Limitations, and Future Directions
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Sample Size | Sex | Age (year) | Height (cm) | Body Mass (kg) | Body Fat (%) | Resting Heart Rate (bpm) | Resting Systolic Blood Pressure (mmHg) | Resting Diastolic Blood Pressure (mmHg) | |
---|---|---|---|---|---|---|---|---|---|
100 mg DYM | 12 | M | 21.7 ± 1.3 | 174.5 ± 7.8 | 78.2 ± 11.1 | 16.7 ± 6.3 | 63.3 ± 7.5 | 123.0 ± 7.0 | 75.8 ± 8.4 |
13 | F | 23.4 ± 2.7 | 162.6 ± 4.4 | 62.7 ± 10.9 | 30.6 ± 6.7 | 66.0 ± 11.3 | 110.2 ± 3.8 | 67.0 ± 7.6 | |
100 mg DYM + 50 mg TCR | 12 | M | 23.5 ± 3.0 | 175.1 ± 6.7 | 83.3 ± 10.3 | 24.2 ± 7.0 | 66.9 ± 10.9 | 120.0 ± 6.4 | 74.1 ± 10.2 |
13 | F | 24.0 ± 6.5 | 163.3 ± 5.1 | 64.4 ± 14.1 | 31.7 ± 7.5 | 61.3 ± 7.6 | 107.5 ± 4.9 | 64.6 ± 5.2 | |
150 mg DYM +25 mg TCR | 12 | M | 24.2 ± 3.3 | 175.7 ± 3.5 | 78.1 ± 5.6 | 19.5 ± 2.9 | 63.6 ± 8.8 | 117.6 ± 5.8 | 71.5 ± 9.1 |
13 | F | 23.1 ± 2.6 | 164.4 ± 5.1 | 62.7 ± 8.0 | 30.7 ± 7.1 | 73.8 ± 10.1 | 111.0 ± 6.8 | 71.0 ± 5.4 | |
150 mg DYM | 12 | M | 22.8 ± 2.6 | 178.3 ± 7.3 | 80.6 ± 8.2 | 19.8 ± 5.6 | 61.1 ± 10.7 | 116.3 ± 7.8 | 74.4 ± 8.7 |
13 | F | 21.8 ± 1.8 | 162.7 ± 8.6 | 63.0 ± 15.0 | 27.7 ± 9.4 | 73.7 ± 11.2 | 111.2 ± 8.0 | 68.1 ± 6.1 | |
Placebo (maltodextrin) | 12 | M | 22.8 ± 3.3 | 117.2 ± 7.7 | 82.5 ± 14.0 | 23.8 ± 7.8 | 66.9 ± 3.9 | 117.7 ± 7.1 | 76.8 ± 7.0 |
13 | F | 22.9 ± 3.8 | 166.5 ± 4.7 | 70.9 ± 11.9 | 31.1 ± 6.9 | 68.8 ± 10.1 | 110.0 ± 5.3 | 67.3 ± 7.6 |
Visit 1 | Visit 2 | Visit 3 | |||
---|---|---|---|---|---|
PRE | PRE | 60 minP | PRE | 60 minP | |
PR Interval (ms) | 145 ± 17 | 146 ± 17 | 147 ± 17 | 145 ± 16 | 149 ± 34 |
QRS Duration (ms) | 88.7 ± 9 | 89.7 ± 9 | 89.8 ± 8.8 | 89.6 ± 9.1 | 89.2 ± 8.9 |
QTC (ms) | 412 ± 23 | 410 ± 23 | 406 ± 24 * | 412 ± 23 | 409 ± 24 |
P Axis (◦) | 56.4 ± 19.1 | 56.5 ± 19.1 | 51.9 ± 22.3 * | 53.9 ± 20.9 | 51.5 ± 22.2 |
R Axis (◦) | 75.7 ± 15.3 | 75.5 ± 17.3 | 74.1 ± 17.5 | 75.4 ± 17.4 | 75.1 ± 17.4 |
T Axis (◦) | 51.8 ± 14 | 53 ± 14.3 | 53.6 ± 17.6 | 52.6 ± 13.6 | 52.4 ± 13.3 |
P Duration (ms) | 94.5 ± 10.2 | 94.2 ± 10.1 | 93.3 ± 11.3 | 93.4 ± 10 | 94.4 ± 10.2 |
RR Interval (ms) | 928 ± 158 | 961 ± 157 # | 1030 ± 166 * | 950 ± 185 | 1024 ± 176 * |
PP Interval (ms) | 935 ± 214 | 959 ± 161 | 1022 ± 173 * | 948 ± 188 | 1010 ± 167 * |
100 mg of DYM | 100 mg of DYM + 50 mg of TCR | 150 mg of DYM + 25 mg of TCR | 150 mg of DYM | Placebo | Average | ||
---|---|---|---|---|---|---|---|
White Blood Cells (× 103/µL) | Visit 2 | 5.37 ± 1.26 | 6.20 ± 1.62 | 5.78 ± 1.26 | 5.76 ± 1.39 | 5.50 ± 1.58 | 5.71 ± 1.43 |
Visit 3 | 5.68 ± 1.62 | 5.92 ± 1.97 | 5.71 ± 1.28 | 5.56 ± 1.30 | 5.53 ± 1.29 | 5.68 ± 1.49 | |
Red Blood Cells (× 106/µL) | Visit 2 | 4.83 ± 0.41 | 4.84 ± 0.41 | 4.64 ± 0.40 | 4.65 ± 0.33 | 4.83 ± 0.57 | 4.76 ± 0.43 |
Visit 3 | 4.83 ± 0.39 | 4.82 ± 0.47 | 4.61 ± 0.40 | 4.67 ± 0.26 | 4.84 ± 0.53 | 4.76 ± 0.42 | |
Hemoglobin (g/dL) | Visit 2 | 14.6 ± 1.0 | 14.4 ± 1.0 | 13.6 ± 1.0 | 14.1 ± 0.9 | 14.2 ± 1.2 | 14.1 ± 1.0 |
Visit 3 | 14.6 ± 1.0 | 14.3 ± 1.1 | 13.7 ± 1.1 | 19.5 ± 25.1 | 14.2 ± 1.2 | 15.2 ± 11.1 | |
Hematocrit (%) | Visit 2 | 43.4 ± 2.9 | 43.7 ± 11.7 | 40.3 ± 2.2 | 42 ± 3 | 42.3 ± 3.4 | 42.3 ± 5.6 |
Visit 3 | 44.1 ± 2.9 | 42.7 ± 3.0 | 40.9 ± 2.6 | 41.4 ± 3.4 | 42.7 ± 3.1 | 42.3 ± 3.2 | |
Mean Corpuscular Volume (fL) | Visit 2 | 89.7 ± 3.6 | 88.5 ± 3.6 | 88.4 ± 4.8 | 88.7 ± 4.7 | 88.0 ± 5.0 | 88.6 ± 4.4 |
Visit 3 | 91.0 ± 3.6 | 88.9 ± 3.2 | 88.8 ± 4.3 | 89.3 ± 5.5 | 88.6 ± 6.2 | 89.3 ± 4.7* | |
Mean Corpuscular Hemoglobin (pg) | Visit 2 | 29.9 ± 1.5 | 29.7 ± 1.0 | 29.9 ± 1.8 | 30.1 ± 1.9 | 29.4 ± 1.8 | 29.8 ± 1.6 |
Visit 3 | 30.2 ± 1.1 | 29.7 ± 1.1 | 30.1 ± 1.6 | 30.5 ± 1.9 | 29.6 ± 1.9 | 30.0 ± 1.6 * | |
Mean Corpuscular Hemoglobin Concentration (g/dL) | Visit 2 | 33.4 ± 0.8 | 33.6 ± 0.8 | 33.3 ± 1.1 | 33.5 ± 0.8 | 33.6 ± 0.9 | 33.5 ± 0.9 |
Visit 3 | 33.0 ± 0.8 | 33.5 ± 0.5 | 33.4 ± 1.1 | 33.4 ± 0.9 | 33.7 ± 0.9 | 33.4 ± 0.9 | |
Red Cell Distribution Width (%) | Visit 2 | 13.4 ± 0.7 | 13.2 ± 0.5 | 13.2 ± 0.9 | 13.2 ± 0.6 | 13.4 ± 0.6 | 13.3 ± 0.6 |
Visit 3 | 13.3 ± 0.5 | 13.3 ± 0.5 | 13.3 ± 0.7 | 13.3 ± 0.6 | 13.4 ± 0.6 | 13.3 ± 0.6 | |
Platelets (× 103/µL) | Visit 2 | 236 ± 55 | 265 ± 48 | 254 ± 42 | 240 ± 49 | 255 ± 55 | 250 ± 50 |
Visit 3 | 220 ± 60 | 246 ± 57 | 256 ± 41 | 247 ± 50 | 266 ± 61 | 247 ± 56 |
100 mg of DYM | 100 mg of DYM + 50 mg of TCR | 150 mg of DYM + 25 mg of TCR | 150 mg of DYM | Placebo | Average | ||
---|---|---|---|---|---|---|---|
Absolute Neutrophils (× 103/µL) | Visit 2 | 2.68 ± 1.04 | 3.06 ± 1.47 | 2.82 ± 0.85 | 2.77 ± 1.24 | 2.56 ± 1.30 | 2.77 ± 1.18 |
Visit 3 | 2.78 ± 1.28 | 2.85 ± 1.58 | 2.82 ± 0.85 | 2.58 ± 1.12 | 2.60 ± 0.90 | 2.72 ± 1.15 | |
Absolute Lymphocytes (× 103/µL) | Visit 2 | 2.09 ± 0.33 | 2.31 ± 0.44 | 2.30 ± 0.50 | 2.13 ± 0.51 | 2.07 ± 0.51 | 2.18 ± 0.47 |
Visit 3 | 2.25 ± 0.50 | 2.31 ± 0.72 | 2.24 ± 0.51 | 2.20 ± 0.48 | 2.20 ± 0.60 | 2.24 ± 0.56 | |
Absolute Monocytes (× 103/µL) | Visit 2 | 0.463 ± 0.124 | 0.519 ± 0.172 | 0.432 ± 0.149 | 0.396 ± 0.112 | 0.475 ± 0.165 | 0.455 ± 0.149 |
Visit 3 | 0.445 ± 0.122 | 0.491 ± 0.216 | 0.470 ± 0.122 | 0.414 ± 0.159 | 0.467 ± 0.134 | 0.458 ± 0.153 | |
Absolute Eosinophils (× 103/µL) | Visit 2 | 0.183 ± 0.169 | 0.162 ± 0.102 | 0.144 ± 0.112 | 0.138 ± 0.077 | 0.175 ± 0.099 | 0.160 ± 0.116 |
Visit 3 | 0.186 ± 0.146 | 0.191 ± 0.177 | 0.157 ± 0.112 | 0.181 ± 0.112 | 0.192 ± 0.132 | 0.181 ± 0.136 * | |
Absolute Basophils (× 103/µL) | Visit 2 | 0.017 ± 0.038 | 0.014 ± 0.036 | 0.012 ± 0.033 | <0.010 | <0.010 | 0.008 ± 0.028 |
Visit 3 | 0.009 ± 0.029 | 0.009 ± 0.029 | 0.027 ± 0.046 | 0.014 ± 0.036 | 0.008 ± 0.028 | 0.014 ± 0.034 | |
Immature Granulocytes (× 103/µL) | Visit 2 | 0.208 ± 0.415 | 0.429 ± 0.978 | 0.080 ± 0.277 | 0.261 ± 0.689 | 0.333 ± 0.637 | 0.256 ± 0.632 |
Visit 3 | 0.318 ± 0.477 | 0.364 ± 0.79 | <0.010 | 0.048 ± 0.218 | 0.208 ± 0.658 | 0.188 ± 0.529 | |
Absolute Immature Granulocytes (× 103/µL) | Visit 2 | 0.017 ± 0.038 | 0.029 ± 0.072 | 0.004 ± 0.020 | 0.009 ± 0.029 | 0.025 ± 0.044 | 0.016 ± 0.043 |
Visit 3 | 0.014 ± 0.035 | 0.014 ± 0.035 | <0.010 | 0.010 ± 0.030 | 0.013 ± 0.034 | 0.010 ± 0.030 |
100 mg of DYM | 100 mg of DYM + 50 mg of TCR | 150 mg of DYM + 25 mg of TCR | 150 mg of DYM | Placebo | Average | ||
---|---|---|---|---|---|---|---|
Glucose (mg/dL) | Visit 2 | 87.5 ± 7.2 | 89.1 ± 7.4 | 90.2 ± 5.2 | 91.2 ± 9.4 | 91.0 ± 8.5 | 89.8 ± 7.7 |
Visit 3 | 87.2 ± 8.5 | 88.2 ± 9.1 | 88.9 ± 6.4 | 91.9 ± 7.6 | 89.9 ± 8.8 | 89.2 ± 8.2 | |
Blood Urea Nitrogen (mg/dL) | Visit 2 | 15.2 ± 4.1 | 14.0 ± 4.0 | 14.0 ± 4.6 | 14.2 ± 4.1 | 14.0 ± 3.3 | 14.3 ± 4.0 |
Visit 3 | 16.5 ± 4.7 | 12.6 ± 3.7# | 14.3 ± 4.9 | 14.0 ± 3.9 | 14.1 ± 2.8 | 14.3 ± 4.2 | |
Creatinine (mg/dL) | Visit 2 | 0.984 ± 0.220 | 0.955 ± 0.161 | 0.870 ± 0.191 | 0.947 ± 0.246 | 0.908 ± 0.172 | 0.932 ± 0.201 |
Visit 3 | 1.003 ± 0.210 | 0.999 ± 0.177 | 0.889 ± 0.198 | 0.981 ± 0.230 | 0.914 ± 0.172 | 0.957 ± 0.200 * | |
Estimated Glomerular Filtration Rate (mL/min/1.73) | Visit 2 | 96.6 ± 17.8 | 94.1 ± 26.3 | 107.8 ± 16.7 | 93.3 ± 29.0 | 104.0 ± 14.9 | 99.3 ± 22.0 |
Visit 3 | 84.1 ± 31.0 | 92.0 ± 15.4 | 105.7 ± 15.4 | 91.6 ± 26.7 | 103.8 ± 16 | 95.5 ± 22.9 * | |
Blood Urea Nitrogen–Creatinine Ratio | Visit 2 | 16.1 ± 5.0 | 14.8 ± 4.4 | 16.0 ± 4.2 | 14.9 ± 5.4 | 15.3 ± 3.3 | 15.4 ± 4.5 |
Visit 3 | 16.7 ± 4.2 | 12.9 ± 4.1 | 16.0 ± 4.0 | 14.7 ± 4.1 | 15.5 ± 3.1 | 15.1 ± 4.1 | |
Sodium (mmol/L) | Visit 2 | 141 ± 2 | 140 ± 2 | 140 ± 2 | 141 ± 2 | 140 ± 2 | 141 ± 2 |
Visit 3 | 141 ± 1 | 140 ± 2 | 140 ± 2 | 141 ± 2 | 141 ± 2 | 141 ± 2 | |
Potassium (mmol/L) | Visit 2 | 4.80 ± 0.42 | 4.62 ± 0.48 | 4.46 ± 0.44 | 4.98 ± 1.91 | 4.35 ± 0.32 | 4.64 ± 0.95 |
Visit 3 | 4.61 ± 0.52 | 4.63 ± 0.83 | 4.41 ± 0.29 | 4.64 ± 0.70 | 4.60 ± 0.42 | 4.58 ± 0.59 | |
Chloride (mmol/L) | Visit 2 | 102 ± 3 | 101 ± 4 | 102 ± 2 | 103 ± 2 | 102 ± 2 | 102 ± 3 |
Visit 3 | 103 ± 2 | 103 ± 2 | 102 ± 2 | 103 ± 3 | 103 ± 2 | 103 ± 2 * | |
Total Carbon Dioxide (mmol/L) | Visit 2 | 24.3 ± 2.3 | 24.3 ± 2.0 | 23.2 ± 2.5 | 23.4 ± 2.2 | 23.9 ± 2.2 | 23.8 ± 2.2 |
Visit 3 | 23.2 ± 2.1 | 23.3 ± 1.7 | 22.2 ± 2.3 | 23.2 ± 2.6 | 24.3 ± 2.3 | 23.3 ± 2.3 * | |
Calcium (mg/dL) | Visit 2 | 9.64 ± 0.27 | 9.53 ± 0.31 | 9.47 ± 0.37 | 9.32 ± 0.45 | 9.53 ± 0.34 | 9.50 ± 0.37 |
Visit 3 | 16.77 ± 23.90 | 9.40 ± 0.34 | 9.44 ± 0.29 | 9.44 ± 0.33 | 9.50 ± 0.38 | 10.87 ± 10.77 |
100 mg of DYM | 100 mg of DYM + 50 mg of TCR | 150 mg of DYM + 25 mg of TCR | 150 mg of DYM | Placebo | Average | ||
---|---|---|---|---|---|---|---|
Total Protein (g/dL) | Visit 2 | 7.18 ± 0.34 | 7.26 ± 0.52 | 7.06 ± 0.53 | 6.92 ± 0.72 | 7.18 ± 0.25 | 7.12 ± 0.51 |
Visit 3 | 7.07 ± 0.31 | 7.17 ± 0.51 | 7.08 ± 0.36 | 7.11 ± 0.76 | 7.18 ± 0.39 | 7.12 ± 0.49 | |
Albumin (A) (g/dL) | Visit 2 | 4.67 ± 0.26 | 4.61 ± 0.33 | 4.60 ± 0.42 | 4.56 ± 0.30 | 4.66 ± 0.32 | 4.62 ± 0.33 |
Visit 3 | 4.65 ± 0.26 | 4.53 ± 0.31 | 4.54 ± 0.38 | 4.62 ± 0.42 | 4.64 ± 0.31 | 4.59 ± 0.34 | |
Total Globulin (G) (g/dL) | Visit 2 | 2.47 ± 0.19 | 2.65 ± 0.40 | 2.58 ± 0.43 | 2.59 ± 0.42 | 2.58 ± 0.35 | 2.57 ± 0.37 |
Visit 3 | 2.43 ± 0.23 | 2.52 ± 0.42 | 2.67 ± 0.38 | 2.67 ± 0.38 | 2.58 ± 0.36 | 2.57 ± 0.37 | |
A/G Ratio | Visit 2 | 1.90 ± 0.19 | 1.78 ± 0.31 | 1.83 ± 0.35 | 1.81 ± 0.31 | 1.84 ± 0.32 | 1.83 ± 0.30 |
Visit 3 | 1.94 ± 0.24 | 1.84 ± 0.3 | 1.73 ± 0.28 | 1.76 ± 0.31 | 1.84 ± 0.29 | 1.82 ± 0.29 | |
Bilirubin, Total (mg/dL) | Visit 2 | 0.529 ± 0.229 | 0.496 ± 0.272 | 0.504 ± 0.348 | 0.424 ± 0.230 | 0.496 ± 0.321 | 0.489 ± 0.282 |
Visit 3 | 0.448 ± 0.250 | 0.468 ± 0.281 | 0.483 ± 0.248 | 0.391 ± 0.095 | 0.454 ± 0.213 | 0.449 ± 0.226 * | |
Alkaline Phosphatase (IU/L) | Visit 2 | 61.8 ± 15.6 | 66.9 ± 23.1 | 66.4 ± 21.3 | 62.5 ± 15.8 | 68.4 ± 18.2 | 65.2 ± 18.9 |
Visit 3 | 60.3 ± 15.5 | 65.5 ± 20.8 | 67.6 ± 21.2 | 62.8 ± 15.6 | 71.4 ± 24.4 | 65.6 ± 19.9 | |
Aspartate Aminotransferase (IU/L) | Visit 2 | 30.9 ± 22.8 | 23.4 ± 10.0 | 21.7 ± 7.2 | 23.2 ± 8.2 | 24.6 ± 8.9 | 24.7 ± 12.9 |
Visit 3 | 28.9 ± 17.7 | 24.7 ± 10.1 | 23.2 ± 8.9 | 24.6 ± 11.6 | 22.0 ± 7.1 | 24.7 ± 11.6 | |
Alanine Aminotransferase (IU/L) | Visit 2 | 23.8 ± 11.7 | 22.5 ± 22.7 | 19.2 ± 9.7 | 14.8 ± 6.4 | 21.3 ± 10.6 | 20.3 ± 13.6 |
Visit 3 | 19.6 ± 7.9 | 22.4 ± 18.0 | 19.7 ± 10 | 15.7 ± 6.7 | 18.8 ± 9.6 | 19.3 ± 11.3 * |
100 mg of DYM | 100 mg of DYM + 50 mg of TCR | 150 mg of DYM + 25 mg of TCR | 150 mg of DYM | Placebo | Average | ||
---|---|---|---|---|---|---|---|
Total Cholesterol (mg/dL) | Visit 2 | 158 ± 26 | 167 ± 30 | 155 ± 34 | 145 ± 22 | 175 ± 22 | 160 ± 28 |
Visit 3 | 160 ± 35 | 166 ± 24 | 157 ± 34 | 148 ± 23 | 167 ± 34 | 160 ± 31 | |
Triglycerides (mg/dL) | Visit 2 | 69.8 ± 29.7 | 86.3 ± 39.6 | 84.9 ± 32.2 | 84.3 ± 39.5 | 96.0 ± 60.6 | 84.3 ± 41.8 |
Visit 3 | 75.3 ± 31.9 | 77.8 ± 35.5 | 91.1 ± 41.3 | 83.4 ± 30.5 | 82.2 ± 44.1 | 81.9 ± 36.8 | |
High-Density Lipoproteins (mg/dL) | Visit 2 | 63.8 ± 13.9 | 56.7 ± 13.7 | 59.3 ± 12.4 | 54.7 ± 12.3 | 58.2 ± 17.4 | 58.5 ± 14.1 |
Visit 3 | 63.2 ± 14.0 | 60.0 ± 16.1 | 61.1 ± 15.6 | 59.5 ± 14.2 | 57.4 ± 22.2 | 60.2 ± 16.5 * | |
Very-Low-Density Lipoproteins (mg/dL) | Visit 2 | 13.9 ± 6.0 | 17.2 ± 7.9 | 15.4 ± 5.5 | 15.8 ± 7.9 | 18.0 ± 11.6 | 16.0 ± 8.0 |
Visit 3 | 15.0 ± 6.6 | 15.8 ± 7.4 | 16.8 ± 7.8 | 16.3 ± 6.1 | 17.2 ± 9.4 | 16.2 ± 7.4 | |
Low-Density Lipoproteins (mg/dL) | Visit 2 | 80.8 ± 21.0 | 93.8 ± 23.9 | 80.0 ± 28.5 | 74.9 ± 19.7 | 98.6 ± 22.4 | 85.6 ± 24.6 |
Visit 3 | 81.6 ± 26.9 | 90.2 ± 24.2 | 79.5 ± 27.3 | 72.3 ± 20.1 | 96.4 ± 24.4 | 84.2 ± 25.7 |
Sample Size | Sex | Carbohydrates (g) | Fat (g) | Protein (g) | Total Calories | p-Value | ||
---|---|---|---|---|---|---|---|---|
100 mg of DYM | 12 | M | Week 1 | 202 ± 43 | 72 ± 20 | 177 ± 27 | 2166 ± 323 | 0.17 |
Week 4 | 206 ± 39 | 64 ± 34 | 166 ± 34 | 2060 ± 311 | ||||
13 | F | Week 1 | 174 ± 52 | 61 ± 26 | 98 ± 34 | 1637 ± 409 | 0.72 | |
Week 4 | 188 ± 46 | 63 ± 25 | 90 ± 25 | 1681 ± 356 | ||||
100 mg of DYM + 50 mg of TCR | 12 | M | Week 1 | 231 ± 30 | 67 ± 20 | 118 ± 33 | 2002 ± 253 | 0.13 |
Week 4 | 229 ± 33 | 75 ± 26 | 126 ± 27 | 2091 ± 268 | ||||
13 | F | Week 1 | 181 ± 31 | 43 ± 12 | 95 ± 22 | 1488 ± 221 | 0.53 | |
Week 4 | 176 ± 29 | 52 ± 19 | 89 ± 22 | 1528 ± 174 | ||||
150 mg of DYM +25 mg of TCR | 12 | M | Week 1 | 238 ± 57 | 74 ± 34 | 147 ± 51 | 2172 ± 330 | 0.48 |
Week 4 | 253 ± 52 | 70 ± 34 | 150 ± 62 | 2244 ± 517 | ||||
13 | F | Week 1 | 186 ± 79 | 58 ± 13 | 90 ± 28 | 1627 ± 337 | 0.75 | |
Week 4 | 194 ± 68 | 54 ± 14 | 96 ± 22 | 1652 ± 307 | ||||
150 mg of DYM | 12 | M | Week 1 | 198 ± 214 | 72 ± 24 | 161 ± 48 | 2087 ± 345 | 0.66 |
Week 4 | 214 ± 43 | 65 ± 20 | 149 ± 49 | 2037 ± 388 | ||||
13 | F | Week 1 | 166 ± 46 | 56 ± 13 | 83 ± 27 | 1501 ± 232 | 0.12 | |
Week 4 | 171 ± 58 | 62 ± 16 | 89 ± 21 | 1600 ± 306 | ||||
Placebo (maltodextrin) | 12 | M | Week 1 | 170 ± 56 | 85 ± 20 | 158 ± 65 | 2078 ± 405 | 0.73 |
Week 4 | 185 ± 42 | 72 ± 23 | 161 ± 60 | 2028 ± 212 | ||||
13 | F | Week 1 | 213 ± 85 | 56 ± 26 | 89 ± 32 | 1711 ± 425 | 0.15 | |
Week 4 | 186 ± 98 | 57 ± 21 | 84 ± 37 | 1598 ± 434 |
© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
Share and Cite
VanDusseldorp, T.A.; Stratton, M.T.; Bailly, A.R.; Holmes, A.J.; Alesi, M.G.; Feito, Y.; Mangine, G.T.; Hester, G.M.; Esmat, T.A.; Barcala, M.; et al. Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults. Nutrients 2020, 12, 654. https://doi.org/10.3390/nu12030654
VanDusseldorp TA, Stratton MT, Bailly AR, Holmes AJ, Alesi MG, Feito Y, Mangine GT, Hester GM, Esmat TA, Barcala M, et al. Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults. Nutrients. 2020; 12(3):654. https://doi.org/10.3390/nu12030654
Chicago/Turabian StyleVanDusseldorp, Trisha A., Matthew T. Stratton, Alyssa R. Bailly, Alyssa J. Holmes, Michaela G. Alesi, Yuri Feito, Gerald T. Mangine, Garrett M. Hester, Tiffany A. Esmat, Megan Barcala, and et al. 2020. "Safety of Short-Term Supplementation with Methylliberine (Dynamine®) Alone and in Combination with TeaCrine® in Young Adults" Nutrients 12, no. 3: 654. https://doi.org/10.3390/nu12030654