Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain
Abstract
:1. Introduction
2. Characteristics of Rheb
3. Rheb–mTOR Signaling in the Brain
4. Role of Rheb in Neurodegeneration in the Hippocampus
5. Mutation of Rheb Leading to Constitutive Activation
6. Mechanisms of Rheb(S16H)-Induced Neuroprotection in the Hippocampus of the Adult Brain
7. Conclusion
Author Contributions
Funding
Conflicts of Interest
References
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Amino Acid Position | Mutation | Cell Type | Reference |
---|---|---|---|
16 | S16H | TSC1/2-overexpressing HEK293T | [128] |
17 | V17G, V17A | fission yeast | [133] |
21 | S21G and S21I | fission yeast | [133] |
35 | Y35N | renal cell carcinoma | [129] |
63 | G63A | HeLa cells | [130] |
64 | Q64L | chicken embryonic fibroblasts | [131] |
120 | K120R | fission yeast | [133] |
153 | N153T | fission yeast | [128,133] |
TSC1/2-overexpressing HEK293T | [128] |
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Moon, G.J.; Shin, M.; Kim, S.R. Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain. Int. J. Mol. Sci. 2020, 21, 2023. https://doi.org/10.3390/ijms21062023
Moon GJ, Shin M, Kim SR. Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain. International Journal of Molecular Sciences. 2020; 21(6):2023. https://doi.org/10.3390/ijms21062023
Chicago/Turabian StyleMoon, Gyeong Joon, Minsang Shin, and Sang Ryong Kim. 2020. "Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain" International Journal of Molecular Sciences 21, no. 6: 2023. https://doi.org/10.3390/ijms21062023