Exploring Molecular Interactions Between Pathogenic Fungi and Crop Host Plants

A special issue of Agriculture (ISSN 2077-0472). This special issue belongs to the section "Crop Protection, Diseases, Pests and Weeds".

Deadline for manuscript submissions: 20 September 2026 | Viewed by 801

Special Issue Editors


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Guest Editor
Institute of Plant Genetics, Breeding and Biotechnology, University of Life Sciences in Lublin, 20-950 Lublin, Poland
Interests: plant genetics; plant molecular biology; plant biotechnology; plant DNA extraction; PCR; molecular markers; disease resistance; plant proteomic; microscopy

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Guest Editor
Institute of Plant Genetics, Breeding and Biotechnology, University of Life Sciences in Lublin, Akademicka 15, 20-950 Lublin, Poland
Interests: resistance; powdery mildew; molecular markers; crops; genetic diversity; population structure
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Special Issue Information

Dear Colleagues,

Pathogenic fungi pose a significant threat to global agriculture by infecting a wide range of crop plants and causing substantial yield losses. In this view, it is essential to find effective methods to limit or combat this problem. Therefore, a deeper and more comprehensive understanding of the mechanisms of action—from both the pathogen’s and the plant’s perspectives—can provide important insights on this topic.

Fungal pathogens utilize a variety of virulence factors to suppress immune responses, invade host tissues, and manipulate host cellular functions for their benefit. Conversely, plants have evolved a range of defense strategies to detect and respond to fungal invasion. This Special Issue focuses on exploring the molecular interactions between pathogenic fungi and their host plants. We wish to highlight the dynamic processes that determine infection outcomes. We welcome articles shedding light on molecular events involved in fungal infection, such as host penetration, cell wall degradation, and nutrient acquisition, alongside plant defense responses like oxidative bursts, hormone signaling, and transcriptional reprogramming. Advances in omics technologies—genomics, transcriptomics, and proteomics—will significantly enhance our understanding of these host–pathogen interactions, allowing for the identification of critical genes and pathways. The insights gained from studying these molecular mechanisms hold great promise for the development of durable, disease-resistant crop varieties through biotechnology and breeding approaches, ultimately contributing to sustainable agriculture and food security.

Dr. Aleksandra Nucia
Prof. Dr. Sylwia Magdalena Okoń
Guest Editors

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Keywords

  • pathogenic fungi
  • plant–pathogen interactions
  • fungal infections mechanism
  • crop diseases
  • host defense responses
  • disease resistance
  • molecular plant pathology

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Published Papers (1 paper)

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Research

22 pages, 3397 KB  
Article
Upregulation of Three NAC Genes in Cucumber Grafted on Figleaf Gourd Contributes to Enhanced Resistance Against FOC Infection
by Hongjia Zhang, Yiwei Peng, Yue Xu, Kang Luo, Gengyun Li, Chao Song, Mingdong Ran, Huameng Huang, Zheng-An Yang, Jian-Xiang Liu, Shuilian He and Yun Zheng
Agriculture 2026, 16(6), 682; https://doi.org/10.3390/agriculture16060682 - 18 Mar 2026
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Abstract
Cucumber Fusarium wilt, which is induced by the soil-borne pathogen Fusarium oxysporum f. sp. Cucumerinum (FOC), represents a highly destructive disease. Cucumber seedling grafted onto figleaf gourd (Cucurbita ficifolia Bouché) rootstock (CFC) demonstrated better resistance to FOC. However, the molecular mechanism [...] Read more.
Cucumber Fusarium wilt, which is induced by the soil-borne pathogen Fusarium oxysporum f. sp. Cucumerinum (FOC), represents a highly destructive disease. Cucumber seedling grafted onto figleaf gourd (Cucurbita ficifolia Bouché) rootstock (CFC) demonstrated better resistance to FOC. However, the molecular mechanism underlying this enhanced disease resistance capability is largely unknown. To elucidate this, we performed transcriptome, small RNA, and degradome sequencing for leaves from CFC and self-grafted cucumbers (SGC) as controls, with and without FOC infections, respectively. Our results indicated that three NAC genes, all predicted as targets of csa-miR164, were significantly up-regulated in CFC after FOC infection. Co-transformation assay in Nicotiana benthamiana confirmed that csa-miR164f directly inhibits NAC2, and transient overexpression of NAC2 in cucumber enhanced resistance to FOC, supporting its positive role in defense. Therefore, our results suggest that three NACs, upregulated in CFC, as an alternative pathway, enhance the reactive oxygen species burst and hypersensitive response, which further elevates the resistance to FOC infection. These results provide new insights into the molecular basis for improved FOC resistance in CFC. Full article
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