Analytical Chemistry: Fundamentals, Current and Future Applications

A special issue of AppliedChem (ISSN 2673-9623).

Deadline for manuscript submissions: 20 September 2026 | Viewed by 4277

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Laboratory of Analytical Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, 15771 Athens, Greece
Interests: analytical chemistry; method validation; antioxidants; natural products
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Special Issue Information

Dear Colleagues,

Analytical chemistry plays an important role in the quality of modern life, contributing to fields as diverse as the environment, health, food, pharmaceuticals, cosmetics, (nano-)materials, foresincs, and agriculture. As a consequence of the importance of analytical chemistry in modern life, a plethora of original scientific research is currently being undertaken and published in scientific journals worldwide.

The scope of the Special Issue is to promote original research mainly, but not exclusively, in the following scientific areas:

  • Classical and modified fundamentals of analytical chemistry;
  • New methods and new techniques of analytical chemistry;
  • Quality control, quality assurance, accreditation, artificial intelligence, and applications;
  • Green extraction, environmentally friendly methods, circular economy, and applications;
  • Applicability of real samples with emphasis on areas of modern life, such as foodomics, emerging contaminants, wastewater-based epidemiology, and food quality.

You may choose our Joint Special Issue in Applied Sciences.

Prof. Dr. Antony C. Calokerinos
Guest Editor

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Keywords

  • analytical chemistry
  • analytical methods
  • analytical techniques
  • green metods
  • circular economy
  • quality control
  • applications

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Published Papers (2 papers)

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Research

32 pages, 5000 KB  
Article
Optimized Folin–Ciocalteu Method for Determination of Total Polyphenols in Medicinal Plants of the Peruvian Amazon: Validation and Application to Twelve Species
by Liliana Ruiz-Vasquez, Lastenia Ruiz Mesia, Martha M. Maco, Jeef A. Zapata, Hivelli Ricopa Cotrina, Marianela Cobos, Viviana Pinedo-Cancino, Fernando Tello and Juan C. Castro
AppliedChem 2026, 6(1), 17; https://doi.org/10.3390/appliedchem6010017 - 2 Mar 2026
Cited by 1 | Viewed by 1895
Abstract
The Folin–Ciocalteu method remains the standard approach for quantifying total phenolics in plant extracts; however, matrix-specific optimization is essential for obtaining accurate results for chemically complex botanical materials. The Peruvian Amazon harbors extensive botanical biodiversity, including numerous medicinal species with uncharacterized phenolic profiles. [...] Read more.
The Folin–Ciocalteu method remains the standard approach for quantifying total phenolics in plant extracts; however, matrix-specific optimization is essential for obtaining accurate results for chemically complex botanical materials. The Peruvian Amazon harbors extensive botanical biodiversity, including numerous medicinal species with uncharacterized phenolic profiles. This study developed and validated a Folin–Ciocalteu method specifically optimized for twelve ethnomedicinal plants representing eleven families from the Peruvian Amazon, following ICH Q2(R2) guidelines. Method optimization established optimal analytical conditions: 765 nm wavelength, 60 min reaction time, 14.05% sodium carbonate, and gallic acid as the reference standard. Comprehensive validation demonstrated excellent linearity (R2 = 0.995–1.000), specificity confirmed through parallel standard addition curves (slope differences < 3%), precision with relative standard deviations below 2.63% for both repeatability and intermediate precision, and accuracy with recovery of 89.43 ± 2.76% meeting AOAC guidelines for complex matrices (80–120%). Robustness testing via response surface methodology confirmed method stability across variations in sodium carbonate concentration (7.50–14.05%), Folin–Ciocalteu reagent dilution (50–100%), and reaction time (30–90 min). Limits of detection and quantification were 4.43 and 13.44 μg/mL, respectively. Application to the twelve species revealed 10-fold variation in total phenolic content (24.6 ± 2.1 to 256.8 ± 4.3 mg gallic acid equivalents per gram dry extract), with Aspidosperma schultesii leaves exhibiting the highest concentration. This validated methodology provides a reliable analytical framework for the quality control and standardization of Amazonian medicinal plants, supporting bioprospecting efforts and therapeutic development. Full article
(This article belongs to the Special Issue Analytical Chemistry: Fundamentals, Current and Future Applications)
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19 pages, 4720 KB  
Article
Enhanced Decolorization and Mineralization of Acid Violet 19 Dye by Potassium Ferrate (VI)
by Bimo Tri Goutomo, Seong Yeop Han, Dian Majid and Il-Kyu Kim
AppliedChem 2026, 6(1), 9; https://doi.org/10.3390/appliedchem6010009 - 2 Feb 2026
Viewed by 965
Abstract
Acid violet 19 (AV19) dye is used in many fields, including photographic film, inks, leather, and textiles. Potassium ferrate (VI) (Fe(VI)) represents a novel oxidant, notable for its strong oxidative capabilities, stability, and environmental sustainability. This research investigates the decolorization and mineralization of [...] Read more.
Acid violet 19 (AV19) dye is used in many fields, including photographic film, inks, leather, and textiles. Potassium ferrate (VI) (Fe(VI)) represents a novel oxidant, notable for its strong oxidative capabilities, stability, and environmental sustainability. This research investigates the decolorization and mineralization of AV19 through the application of Fe(VI), with a particular emphasis on essential parameters, including pH, molar ratios, and temperature variations. The study ascertained that the optimal conditions for AV19 oxidation are a pH of 7.0, a molar ratio of AV19: Fe(VI) of 1:5, and a temperature of 45 °C with a reaction time of 12 min. The decolorization efficiency achieved was approximately 98%, and the mineralization was 31%. The degradation process yielded intermediates, such as sulfonic acid derivatives, benzoic acid, benzene, and cyclohexane compounds, which were further oxidized into acetic acid, carbon dioxide, and water. Comprehensive computational toxicity evaluations confirmed that both the intermediates and the final products are non-toxic. Full article
(This article belongs to the Special Issue Analytical Chemistry: Fundamentals, Current and Future Applications)
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