Protein Therapy for Cardiovascular Disease Treatment

Dear Colleagues,

Myocardial infarction (MI) occurs due to the blockage of coronary arteries, leading to ischemia of the myocardium and inflammatory cell death. The dead cardiac tissue is replaced by fibrous scar tissue, causing a decline in myocardial contractile strength and impacting the functional capacity of the heart. While treatments such as stent placement, vascular bypass, and transplantation are beneficial, they have limitations. There is an urgent need to develop novel protein therapeutics to control inflammation and to improve the regenerative capacity of the heart in the setting of acute MI and chronic heart failure.

New approaches involving biologics, cell-based, or a combination of biologics and cell therapies are emerging as potential means for cardiovascular diseases. The development of an effective delivery system is crucial to ensure that therapeutic proteins reach the target tissues in the body. The exploration of various methods, including injections, implants, and other advanced drug and cell delivery technologies, is essential for this purpose.

Prof. Dr. Jianjie Ma
Dr. Ki Ho Park
Guest Editors

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• myocardial infarction
• heart failure
• vein graft
• intimal hyperplasia
• aneurysm
• stem cells
• nanoparticle
• transplantation
• CRISPR
• MyoAAV
• tissue repair
• inflammation