Soft Tissue Modeling, Bioengineering and Regeneration

Dear Colleagues,

Soft tissue is comprised of a diverse array of tissue types including skin, fat, muscle, nerves, blood vessels, ligaments, tendons, and other fibrous tissues. These tissues play a vital role in maintaining the structural integrity and assisting with the function of the human body. The field of soft tissue modeling, bioengineering, and regenerative medicine has witnessed remarkable advancements in recent years. It holds great promise for addressing tissue damage, degenerative conditions, and various other clinical challenges. This Topical Collection of Bioengineering, entitled "Soft Tissue Modeling, Bioengineering and Regeneration", aims to provide a comprehensive platform for researchers, scientists, and clinicians to share cutting-edge developments and novel insights in the realm of soft tissue engineering. This topical collection will focus on state-of-the-art computational, experimental, and translational approaches to model development and understanding the behavior, biomechanics, and cellular responses of various soft tissues. Topics of interest for this Topical Collection include, but are not limited to, the following:

1. Biomaterials and scaffold design: novel materials and scaffold fabrication techniques for soft-tissue regeneration and repair, promoting functional-tissue
2. Cellular responses and mechanotransduction: investigations into cell behavior, signaling pathways, and mechanotransduction mechanisms during tissue development, injury, and regeneration.
3. Biofabrication and 3D printing: advances in biofabrication and 3D-printing technologies for creating complex soft tissue constructs and organoids.
4. Biomechanics and computational modeling: computational simulations and biomechanical analyses to understand soft-tissue behavior under physiological and pathological conditions.
5. Vascularization and innervation: strategies to promote vascularization and nerve regeneration within engineered soft-tissue constructs.
6. Reconstructive and regenerative therapies and clinical translation: preclinical and clinical studies on soft-tissue reconstructive and regenerative therapies and translational approaches to address real-world medical challenges.
7. Bioimaging and non-invasive monitoring: innovations in non-invasive imaging techniques for the diagnosis/prognosis of soft tissue-related diseases, surgical reconstruction, regeneration, and healing progress.
8. Immunomodulation and biointerface engineering: immune response modulation and the development of biointerfaces to enhance tissue integration, reduce tissue injury, and to evaluate long-term functionality.

This Topical Collection invites original research articles, reviews, case reports, and short communications that contribute to the advancement of soft tissue modeling and its application in tissue engineering and regenerative medicine. We encourage multidisciplinary collaborations and welcome studies that bridge the gap between engineering, biology, and clinical practice.

The interdisciplinary nature of this topic will allow researchers and clinicians to exchange ideas, share knowledge, and foster collaborations that could lead to significant breakthroughs in this field. Through this collective endeavor, we aim to accelerate the progress in soft tissue engineering and regenerative medicine, paving the way for transformative therapies and improved patient outcomes in the future.

Prof. Dr. Chunfeng Zhao
Dr. Aida K. Sarcon
Collection Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Bioengineering is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• soft tissue
• preclinical models
• scaffolds
• modeling
• tissue engineering
• regenerative medicine