Organoids and Models from Stem Cells
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 100
Special Issue Editors
Interests: insulin-secreting cells; stem cell differentiation; stem cell culture; stem cell biology; regenerative medicine; tissue engineering; stem cells; ovary cell; culture differentiation; tissue regeneration
Interests: epigenetics and gene regulation; morphology and functional imaging of cells; stem cell biology; development, developmental genetics, pattern formation and embryology in animals; gene therapy; cell therapy; regenerative medicine
Special Issue Information
Dear Colleagues,
The role of the cellular microenvironment and tissue architecture was firstly described in the pioneering studies carried out over 20 years ago by Dr. Mina Bissel in murine mammary cells. Her experiments demonstrated that growing mammary cells in a solution of extracellular matrix induced cells to cluster into 3D structures and to regain their ability to produce milk in vitro, showing a direct correlation between tridimensional organization and function preservation. These observations are presently regarded as the beginning of the 3D culture and organoid era. A lot has happened since then, and a great number of tridimensional cell culture platforms have been developed to create models that bridge the gap between the in vivo complexity and the oversimplified conventional two-dimension (2D) in vitro cultures. These newly created tridimensional cultures more accurately reflect what normally happens within the tissues of the living organisms, preserving the original cell–cell and cell–ECM interactions, ensuring cell proliferation, boosting differentiation, and maintaining cell morphology and behavior, alongside an optimal access to nutrients. These features greatly empower their predictive capability and may significantly reduce the need for experimental animal testing in drug screening, organ development, and disease mechanism studies.
In this Special Issue, we will collect reports, reviews, and protocols related to the generation of well-characterized, reproducible, highly predictive 3D in vitro platforms in which these concepts are being pursued to encourage and stimulate the scientific community to design and produce models for the laboratory that mimic cell guidance conditions as they occur in vivo, spanning from mechanical cues, such as stiffness and 3D architecture, to chemical and soluble factors that tune the cell microenvironment.
Prof. Dr. Tiziana A. L. Brevini
Prof. Dr. Georgia Pennarossa
Guest Editors
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Keywords
- cellular microenvironment
- 3D culture
- organoid
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