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Cells publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Autophagy Meets Aging 2025

edited by

Christiaan Leeuwenburgh

and

Anna Picca

submission deadline 10 Jun 2025 | 3 articles | Viewed by 10583 | Submission Open

Keywords: aging; autophagy; cellular quality control; mitochondrial dysfunction; redox biology; extracellular vesicles trafficking; inflammation; biomarkers; omics; behavioral and pharmacological interventions

(This special issue belongs to the Section Autophagy)

Modelling Tissue Microenvironments in Development and Disease

edited by

Jeremy M. Crook

, Eva Tomaskovic-Crook, Maryam Alsadat Rad and Panthipa Suwannakot

submission deadline 10 Jun 2025 | 1 articles | Viewed by 2323 | Submission Open

Keywords: tissue microenvironment; developmental biology; disease biology; 3D cell culture; organoids; spheroids; bioprinting; tissue culture; tissue engineering; in silico; extracellular matrix; mechanobiology; signalling molecules; regenerative medicine

(This special issue belongs to the Section Tissues and Organs)

Extracellular Vesicles and Drug Delivery System for Developing Cancer Therapeutics

edited by

Goo-Bo Jeong

submission deadline 10 Jun 2025 | 1 articles | Viewed by 1996 | Submission Open

Keywords: extracellular vesicles; drug delivery; cancer therapeutics

(This special issue belongs to the Section Cell Microenvironment)

Mechanistic Insights into Nanomaterial-Induced Immunotoxicity: Exploring Pathways of Immune Dysregulation

edited by

Pradeep K. Shukla

submission deadline 10 Jun 2025 | Viewed by 183 | Submission Open

Keywords: nanomaterials; immune cells; macrophages; inflammasomes; immunotoxicity; immune responses

(This special issue belongs to the Section Cellular Immunology)

Progress in Cancer Immunotherapies

edited by

Van Ngu Trinh

and Phuc Loi Luu

submission deadline 15 Jun 2025 | 1 articles | Viewed by 4483 | Submission Open

Keywords: cancer immunotherapy; immune checkpoint inhibitors; personalized immunotherapy; tumor microenvironment; biomarkers in immunotherapy

(This special issue belongs to the Section Cellular Immunology)

State-of-the-Art Research on Histone Deacetylases (HDACs) and Histone Acetyltransferases (HATs)

edited by

Xiaohong Zhang

submission deadline 15 Jun 2025 | 2 articles | Viewed by 3889 | Submission Open

Keywords: histone deacetylases; cancer; metabolism; immunotherapy; tumor microenvironment; DNA damage response; cell cycle

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Cellular and Clinical Mechanisms of Obesity and Diabetes and Their Complications

edited by

Eirini Kostopoulou

and

María Güemes

submission deadline 15 Jun 2025 | 2 articles | Viewed by 3793 | Submission Open

Keywords: obesity; type 1 diabetes; type 2 diabetes; metabolic disorders; complications; signaling pathways; pathophysiology; insulin; β -cell

(This special issue belongs to the Section Cellular Pathology)

Recent Advances in Cancer Therapy—Second Edition

edited by

Anand Singh

and

Roma Pahwa

submission deadline 15 Jun 2025 | 1 articles | Viewed by 1968 | Submission Open

Keywords: cancer; immunotherapy; targeted therapy; gene therapy; microRNA (miRNA); chemotherapy; drug resistance; chimeric antigen receptor T-cell (CART) therapy; T-cell receptor (TCR) therapy; tumor-infiltrating lymphocytes (TILs); apoptosis

Targeting Cellular Microenvironment in Aging and Disease

edited by

Alexander Dityatev

and Egor Dzyubenko

submission deadline 15 Jun 2025 | Viewed by 420 | Submission Open

Keywords: proteoglycans; glycans; glycoproteins; matricellular proteins; integrins; matrix metalloproteinases; extracellular vesicles; EV release; exosomes; extracellular scaffold; ECM remodeling; fibrosis; ECM gene therapy; ECM pharmacology; synthetic ECM

(This special issue belongs to the Section Cellular Aging)

Endoplasmic Reticulum Stress and Human Disease: Lessons from Animal Models

edited by Sébastien Gaumer

submission deadline 15 Jun 2025 | Viewed by 243 | Submission Open

Keywords: endoplasmic reticulum (ER); ER stress; human diseases; neurodegenerative disorders; diabetes; cardiovascular diseases; cancer; animal models; pathomechanisms; therapeutic strategies

(This special issue belongs to the Section Cellular Pathology)

Synaptic Dysregulation in Nervous System Disorders

edited by Pragya Goel

submission deadline 15 Jun 2025 | Viewed by 205 | Submission Open

Keywords: synapses; synaptic transmission; synaptic plasticity; neurodegeneration; neuropsychiatric disorders; neurodevelopmental diseases

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Mechanisms of Tumor Pathogenesis

edited by

Saverio Candido

and Alessandro Lavoro

submission deadline 20 Jun 2025 | 5 articles | Viewed by 10398 | Submission Open

Keywords: cancer; therapeutic targets; biomarkers; epigenetics; DNA methylation; microRNAs; somatic mutations; germline mutations; chromatin remodeling; histone modifications

(This special issue belongs to the Section Cellular Pathology)

Recent Advances in Regenerative Dentistry—Second Edition

edited by

Li Xiao

submission deadline 20 Jun 2025 | 5 articles | Viewed by 8366 | Submission Open

Keywords: oral stem cells; oral tissue regeneration; bioengineering; dental materials; stem cell banking

(This special issue belongs to the Section Tissues and Organs)

Advances in Spermatogenesis

edited by

Zhibing Zhang

and Changmin Niu

submission deadline 20 Jun 2025 | 5 articles | Viewed by 5556 | Submission Open

Keywords: spermatogenesis; mitosis; meiosis; spermiogenesis; omics; organoid culture; infertility; contraception

(This special issue belongs to the Section Reproductive Cells and Development)

Molecular and Cellular Insights into Platelet Function

edited by

Stepan Gambaryan

and

Mikhail A. Panteleev

submission deadline 20 Jun 2025 | 6 articles | Viewed by 4756 | Submission Open

Keywords: platelet; wound healing; fibrinolysis; regeneration and tissue remodeling; angiogenesis; lymphatic development; inflammation and immunity

(This special issue belongs to the Section Cells of the Cardiovascular System)

Molecular Mechanism of Liver Transplantation

edited by Carmen Peralta and Juan Carlos Cutrin

submission deadline 20 Jun 2025 | 1 articles | Viewed by 3032 | Submission Open

Keywords: liver transplantation; ischemia-reperfusion injury; signaling pathways; graft dysfunction; sterile inflammation; liver regeneration; fatty grafts; normothermic machine perfusion; defatting strategies

(This special issue belongs to the Section Tissues and Organs)

Drosophila: Contribution to Cell Research

edited by

Xiaoyan Zheng

submission deadline 20 Jun 2025 | 1 articles | Viewed by 2687 | Submission Open

Keywords: Drosophila; cell research; cell biology; gene function; disease processes; fruit fly

Molecular and Cellular Mechanisms of Central Nervous System Autoimmunity

edited by

Refik Pul

Christoph Kleinschnitz

and

Jelena Skuljec

submission deadline 20 Jun 2025 | 1 articles | Viewed by 1399 | Submission Open

Keywords: neuroimmunity; central nervous system; autoimmunity; immune tolerance; multiple sclerosis; antibody-mediated autoimmunity; cellular immunology; neuroinflammation

(This special issue belongs to the Section Cells of the Nervous System)

Molecular Insight into the Pathogenesis of Spontaneous Preterm Birth

edited by Khondoker M. Akram

submission deadline 20 Jun 2025 | 1 articles | Viewed by 1269 | Submission Open

Keywords: pathogenesis of preterm birth; placental dysfunctions in preterm birth; environmental impacts on placental function in preterm birth; vaginal dysbiosis in preterm birth

(This special issue belongs to the Section Cellular Pathology)

T Cells in Inflammation and Cancer

edited by

Kihong Lim

submission deadline 20 Jun 2025 | 1 articles | Viewed by 1090 | Submission Open

Keywords: T cell; immunity; disease; infection; cancer; inflammation; pathology; immunotherapy

(This special issue belongs to the Section Cellular Immunology)

Immunoregulatory Functions of Mesenchymal Stem Cells (MSCs)

edited by

Joni H. Ylostalo

submission deadline 20 Jun 2025 | Viewed by 269 | Submission Open

Keywords: mesenchymal stem cells; MSCs; immunoregulation; immunosuppression

(This special issue belongs to the Section Stem Cells)

Advances in Cell Therapy for Leukemias

edited by Salman Otoukesh and Idoroenyi U. Amanam

submission deadline 20 Jun 2025 | Viewed by 117 | Submission Open

Keywords: acute leukemia; cell therapy; target cell therapy; immunotherapy; bi-specific therapy; relapse leukemia; refractory leukemia

(This special issue belongs to the Section Cell and Gene Therapy)

Current Status and Future Challenges of Liquid Biopsy

edited by

Shuta Ohara

and

Kenichi Suda

submission deadline 25 Jun 2025 | 4 articles | Viewed by 12343 | Submission Open

Keywords: liquid biopsy; biomarker; minimal residual disease (MRD); circulating tumor DNA (ctDNA); tumor-educated platelet (TEP)

(This special issue belongs to the Section Cellular Pathology)

Emerging Therapies for Hereditary Ataxia—Second Edition

edited by

Kah-Hui Wong

Patrícia Maciel

and

Piergiorgio La Rosa

submission deadline 25 Jun 2025 | Viewed by 201 | Submission Open

Keywords: hereditary ataxia; movement disorder; emerging neurotherapeutics; complementary and alternative medicines; secondary metabolites; neuroprotection; mitigation of oxidative stress; mitochondria-targeted antioxidants

Gene Editing Therapies for Hereditary Diseases

edited by

Jacques P. Tremblay

submission deadline 25 Jun 2025 | Viewed by 157 | Submission Open

Keywords: gene therapy; base editing; prime editing; genome editing; hereditary diseases

Cellular and Molecular Mechanisms in Gynecological Disorders

edited by

Qiwei Yang

submission deadline 30 Jun 2025 | 13 articles | Viewed by 20082 | Submission Open

Keywords: uterus; ovary; breast; cervix; cancer; endometriosis; leiomyoma; adenomyosis; polycystic ovary syndrome; female infertility; pathways; cell atlas; transcriptome; epigenome

(This special issue belongs to the Section Reproductive Cells and Development)

Understanding Spinal Cord Injury and Repair: From Molecules to Neurocircuits and Multimodal Prostheses

edited by

Yang D. Teng

submission deadline 30 Jun 2025 | 9 articles | Viewed by 18109 | Submission Open

(This special issue belongs to the Section Cells of the Nervous System)

Insight into Cardiomyopathy

edited by Sobuj Mia

submission deadline 30 Jun 2025 | 1 articles | Viewed by 15216 | Submission Open

Keywords: heart failure; ventricular dysfunction; hypertrophic cardiomyopathy; dilated cardiomyopathy; cardiac fibrosis; cardiac hypertrophy; biomarkers

(This special issue belongs to the Section Cells of the Cardiovascular System)

Highlights in Red Blood Cell Research

edited by

Anna Bogdanova

and

Lars Kaestner

submission deadline 30 Jun 2025 | 3 articles | Viewed by 14190 | Submission Open

Keywords: red blood cells; anemia; transfusion; erythropoiesis; signaling

Cellular and Molecular Mechanisms in Immune Regulation

edited by Fábio Rinaldo Santori and Natalia B. Ivanova

submission deadline 30 Jun 2025 | 8 articles | Viewed by 11866 | Submission Open

Keywords: innate immunity; dendritic cells; macrophages; T cells; B cells; cytokines; immunotherapy

(This special issue belongs to the Section Cellular Immunology)

Exclusive Review Papers in Autophagy—Second Edition

edited by

Harald W. Platta

submission deadline 30 Jun 2025 | 4 articles | Viewed by 9980 | Submission Open

Keywords: biquitination; autophagy; peroxisomes; macroautophagy; pexophagy; mitophagy; lysosome; vacuole; organellar homeostasis; posttranslational modifications; lipids; signaling cascades

(This special issue belongs to the Section Autophagy)

Radiation-Induced Brain Injury: Molecular Mechanisms and Therapeutic Strategies

edited by

Feng Ru Tang

submission deadline 30 Jun 2025 | 3 articles | Viewed by 9312 | Submission Open

Keywords: radiation injury; brain; neurological and neuropsychiatric disorders; molecular mechanisms; novel therapeutic approaches

(This special issue belongs to the Section Cells of the Nervous System)

Natural Products in Neurodegenerative Diseases: Current Trends and Future Perspectives

edited by

Anthony Tsarbopoulos

and Nikolaos Kokras

submission deadline 30 Jun 2025 | 3 articles | Viewed by 8589 | Submission Open

Keywords: bioactive compounds; protein aggregation processes in AD; cognitive; anxiolytic and antidepressant effects

(This special issue belongs to the Section Cells of the Nervous System)

Charming Micro-Insights into Health and Diseases

edited by

Alexander E. Kalyuzhny

submission deadline 30 Jun 2025 | 4 articles | Viewed by 8205 | Submission Open

Keywords: cellular pathology of cancers neural cell biology cellular antivirus immune responses cell therapies cellular signaling cell research in animal models cellular metabolism protein quality control proteasomal degradation and autophagy

Male Infertility Update: Current Knowledge on Etiology, Comorbidities, Diagnosis and Treatment: Preclinical Topics

edited by

Francesco Lotti

and

Mario Maggi

submission deadline 30 Jun 2025 | 3 articles | Viewed by 7367 | Submission Open

Keywords: male infertility; diagnosis; treatment; etiology; pre-testicular/testicular/post-testicular causes; genetic causes; seminal parameters; hormonal parameters; ultrasound; general health; azoospermia

(This special issue belongs to the Section Reproductive Cells and Development)

Heat Shock Proteins and Human Cancers

edited by

Alexander E. Kabakov

submission deadline 30 Jun 2025 | 5 articles | Viewed by 7119 | Submission Open

Keywords: heat shock protein; glucose-regulated protein; cancer; tumorigenesis; theranostics; anticancer vaccine

Epigenetics and DNA Repair: Regulatory Mechanisms and Therapeutic Opportunities

edited by

Vasily M. Studitsky

submission deadline 30 Jun 2025 | 3 articles | Viewed by 6418 | Submission Open

Keywords: DNA damage; DNA repair; epigenetics; chromatin; remodeling

(This special issue belongs to the Section Cell Nuclei: Function, Transport and Receptors)

Astrocyte Reprogramming and Brain Homeostasis

edited by Dimitra Thomaidou and Elsa Papadimitriou

submission deadline 30 Jun 2025 | 2 articles | Viewed by 4757 | Submission Open

Keywords: in vitro astrocytic reprogramming; in vivo astrocytic reprogramming; induced neurons; transcription factors; miRNAs; small molecules; direct reprogramming mechanisms; scRNA-seq; gene regulatory networks; astrocytic metabolism; metabolic reprogramming

(This special issue belongs to the Section Cells of the Nervous System)

Synaptic Plasticity in Brain and Nerves: New Vistas in Health and Diseases (2nd Edition)

edited by

Jean-Marie Billard

submission deadline 30 Jun 2025 | 2 articles | Viewed by 4357 | Submission Open

Keywords: cellular networks; synaptic strength; Hebbian plasticity; homeostatic plasticity; neuron– glia interactions; brain disorders; cognitive functions

(This special issue belongs to the Section Cells of the Nervous System)

Kynurenic Acid: Unveiling Its Impact on the Brain’s Neurotransmission and Neurological Disorders

edited by Korrapati V. Sathyasaikumar, Sarah Beggiato and

Verónica Pérez de la Cruz

submission deadline 30 Jun 2025 | 2 articles | Viewed by 3634 | Submission Open

Keywords: kynurenic acid; cognition; aging; neuromodulation; neurodegeneration; neurodevelopment; neuroinflammation; tryptophan catabolism

(This special issue belongs to the Section Cell Signaling)

Cellular Signaling and Therapeutic Approaches of Pulmonary Fibrosis

edited by Jennifer Speth

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3458 | Submission Open

Keywords: pulmonary fibrosis; resolution; cellular interactions

(This special issue belongs to the Section Tissues and Organs)

Advances in Melanoma Immunotherapy

edited by Jeffrey D. McBride

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3373 | Submission Open

Keywords: melanoma immunotherapy; therapeutic targets; immune modulation; oncolytic viruses; checkpoint inhibitors; cancer vaccines; tumor biomarkers; tumor microenvironment; treatment strategies

(This special issue belongs to the Section Cellular Immunology)

Advancements in Cellular Immunotherapies in the Immune Checkpoint Inhibitor Era for Cancer Treatment

edited by

Andrés Tittarelli

and

Flavio Salazar-Onfray

submission deadline 30 Jun 2025 | 1 articles | Viewed by 3320 | Submission Open

Keywords: CAR-T cells; NK-cell immunotherapy; adoptive T-cell transfer; dendritic cell cancer vaccines; whole-tumor-cell vaccines

(This special issue belongs to the Section Cellular Immunology)

Recent Developments in the Role of Enteroendocrine Cells in Gastrointestinal and Non-gastrointestinal Disorders

edited by

Tarek Mazzawi

and Trygve Hausken

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2955 | Submission Open

Keywords: enteroendocrine; stem cells; quantification; transcriptome; immunohistochemistry; gut hormones; obesity; Parkinson’ s disease; diabetes; IBD

Novel and Experimental Strategies for the Treatment of Neurodegenerative Diseases

edited by

Morten Meyer

and Justyna Okarmus

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2739 | Submission Open

Keywords: neurodegenerative diseases; experimental treatments; stem cell transplantation; immunotherapy; gene therapy; focused ultrasound; neuroprotective agents; Parkinson's disease; Alzheimer's disease; Huntington’ s disease; amyotrophic lateral sclerosis

(This special issue belongs to the Section Cells of the Nervous System)

Axonal Transport: Mechanisms, Disorders, and Therapeutic Approaches

edited by Yuxiang Xie and Jingqi Yan

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2726 | Submission Open

Keywords: axonal transport; motor proteins; autophagy– lysosome pathway; neurodegenerative diseases; therapeutic strategies

The Role of Hypoxia-Inducible Factors (HIFs) in Human Diseases

edited by

Efrosyni Paraskeva

and

George Simos

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2564 | Submission Open

Keywords: oxygen; hypoxia; HIF; transcription; cancer; anemia; ischemia; cardiovascular disorders; erythrocytosis; pulmonary hypertension

(This special issue belongs to the Section Cellular Pathology)

The Role of Inflammation in AMD (Multifactorial Age-Related Macular Degeneration)—Volume II

edited by Kai Kaarniranta,

Anu Kauppinen

and

Heping Xu

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2465 | Submission Open

Keywords: aging; autophagy; degeneration; inflammation; macula; oxidative stress; retina

(This special issue belongs to the Section Cellular Immunology)

The Role of Oxidative Stress in Cardiovascular Diseases—2nd Edition

edited by

Liya Yin

and

Chuanxi Cai

submission deadline 30 Jun 2025 | 1 articles | Viewed by 2299 | Submission Open

Keywords: oxidative stress; antioxidants; apoptosis; atherosclerosis; blood vessel; heart failure; hypertension; inflammation; mitochondria; microcirculation; reactive oxygen species

(This special issue belongs to the Section Cells of the Cardiovascular System)

Sepsis: Pathogenesis, Pathophysiology, Molecular and Cellular Mechanisms and Immunity

edited by

Guozheng Wang

and

Simon Abrams

submission deadline 30 Jun 2025 | 2 articles | Viewed by 2125 | Submission Open

Keywords: sepsis; bacterial infection; PAMPs; DAMPs; TLRs; small RNAs; RNA splicing; DNA recombination; signaling pathways; cell death; NET/NETosis; coagulopathy; DIC; toxins; complements

(This special issue belongs to the Section Cellular Immunology)

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