Neurodevelopmental Disabilities (NDDs): From Cellular and Molecular Mechanisms to Innovative Therapy
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 31 December 2024 | Viewed by 111
Special Issue Editors
Interests: intellectual disability and developmental epileptic encephalopathies; ARX-KDM5C; disease models; convergent transcriptional pathways
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues，
Neurodevelopmental disabilities (NDDs) refer to a range of conditions that affect the development of the brain and central nervous system, leading to impairments in cognitive, social, and motor functions. These disorders, which include conditions such as autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and intellectual disability (ID), are characterized by abnormalities in neural connectivity and synaptic plasticity. This Special Issue delves into the intricate world of neurodevelopmental disabilities, exploring the underlying cellular and molecular mechanisms that contribute to their development.
NDDs are associated with alterations in neuronal migration, differentiation, and survival. Dysregulation of gene expression, epigenetic modifications, and oxidative stress have also been implicated in the pathogenesis of these disorders. In addition, abnormalities in neurotransmitter systems, particularly dopamine and glutamate, have been observed in individuals with NDDs. Molecular mechanisms underlying NDDs involve complex interactions between genetic and environmental factors. Mutations in genes encoding proteins involved in synaptic function, such as SHANK3 and NLGN4X, have been identified as risk factors for ASD. Environmental exposures, including prenatal infections and toxins, may interact with genetic susceptibility to increase the risk of developing NDDs.
Understanding the cellular and molecular mechanisms of NDDs is crucial for developing targeted therapies and interventions for individuals affected by these disorders. Our Special Issue aims to provide insights for the development of innovative therapies that target these mechanisms at the cellular level, offering hope for improved outcomes for individuals with NDDs.
All types of manuscripts, such as research papers and reviews, are welcome. We look forward to your contributions.
Dr. Maria Giuseppina Miano
Dr. Denise Drongitis
Guest Editors
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Keywords
- neurodevelopmental disorders
- cellular mechanisms
- molecular mechanisms
- genetic factors
- brain plasticity
- innovative therapies
- KDM5C
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