Recent Advances in the Study of Tau Protein
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".
Deadline for manuscript submissions: 20 November 2025 | Viewed by 11
Special Issue Editor
Interests: Alzheimer’s disease; tau; lyve1; macrophages; meninges
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Tau, an intrinsically disordered protein first discovered as a component of neurofibrillary tangles in Alzheimer's disease, is also a crucial protein in a group of neurodegenerative disorders known as tauopathies. The protein undergoes a multitude of post-translational and structural changes, which disrupt its function and contribute to these deadly disorders. Throughout the disease, tau changes from an inflexible state to filaments with unique morphologies for the disorders involved. In addition to its cardinal role as a protein capable of polymerizing and stabilizing microtubules, various novel and intriguing functions of tau have been discovered in recent decades, raising the prospect that the protein may have a significant impact on the central nervous system. Furthermore, the mechanisms by which tau can play a role in disease etiology are constantly investigated and unraveled.
In this Special Issue, we invite original research articles (in vitro, animal, and human investigations, as well as in silico studies), review articles, and perspectives that will drive ongoing efforts to better understand tau protein in physiology and disease. We welcome submissions on a wide range of topics, including (but not limited to) tau structure and function, mechanism of action, immunological modulatory variables, aggregation and pathogenesis, interactions with tau binding partners, experimental therapeutics, tauopathy models, and biomarkers.
Dr. Santosh Jadhav
Guest Editor
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Keywords
- tau protein
- post-translational modification
- tauopathy filaments
- neuro-immune interactions
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