Novel Biomarkers in Eye Diseases
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Pathology".
Deadline for manuscript submissions: 10 February 2025 | Viewed by 34
Special Issue Editor
Interests: neuromediators; ocular diseases; biomarkers; epigenetics; genetic variants
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
This Special Issue will explore biomarkers in eye diseases and their usefulness as indicators of pathological processes (diagnosis) or pharmacologic responses to a therapeutic intervention (precision medicine). Although the relevance of biomarkers in differential diagnosis is indisputable, the debate around the usefulness of eye biomarkers in ophthalmological practice is intensifying. Most biomarkers are found through expansive explorative studies on eye tissues and ocular fluids collected in the clinic and/or during surgery. Some biomarkers have been identified as key mediators of ocular inflammation, while others have been related to matrix remodeling, profibrogenesis, and angiogenesis/vasculogenesis. The concept of the eye as a mirror of the brain or gut has increased the interest in the utilization of tear biomarkers as indicators in the early diagnosis of diseases linked to the brain–gut–eye axis.
Tears, as well as aqueous, vitreous, and even vitreal reflux, represent a good biological matrix. Biomarker profiling has been reported in dry eye, eye infections, vitreoretinal diseases, microvascular eye diseases, diabetic retinopathies, intravitreal treatments, neurodegenerative and metabolic eye disorders, and eye tumors. However, full knowledge of biomarkers’ interplay with the microenvironment is still necessary in the case of individualized therapy (intravitreal injections).
We welcome original research and review articles covering any aspect of eye biomarkers detected using different biological matrix and devices, conventional tests, array chips, and next-generation microfluidic chips. Studies into the latest developments in how eye biomarkers can be exploited for the development of new targeted therapies or for patient follow-up will be considered. The aim will be to select, from a wide cluster of mediators, major actors in the development of new alternative strategies in the field of ophthalmology.
Dr. Alessandra Micera
Guest Editor
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Keywords
- biomarkers
- tears
- ocular surface
- retina
- ocular fluids
- inflammation
- neuromodulation
- parainflammation
- omics
- lab-on-chip
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