Glial Cells: Physiological and Pathological Perspective
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 31 March 2025 | Viewed by 11
Special Issue Editor
Interests: glia cells; myelination; neurodegenerative diseases; cancer neuroscience
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative diseases of the central nervous system (CNS), including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis (ALS), are characterized by progressive neuronal loss and dysfunction. Glial cells, comprising astrocytes, microglia, oligodendrocytes, and ependymal cells, play crucial roles in maintaining CNS homeostasis, neuronal support, and response to injury. Emerging evidence implicates glial cells as central players in the pathogenesis of neurodegenerative diseases. Astrocytes contribute to neuroinflammation and neuroprotection, yet their dysfunction can exacerbate neuronal damage. Microglia, the resident immune cells of the CNS, are pivotal in mediating inflammatory responses. Oligodendrocytes, responsible for myelination, are affected in diseases such as multiple sclerosis, where demyelination impairs neural conductivity and leads to neurodegeneration. Additionally, the interactions between glial cells and neurons are critical in modulating the progression of disease. Understanding the molecular mechanisms governing glial cell function and dysfunction would provide insights into the complex interplay between these cells and neurons in neurodegenerative diseases. This knowledge is pivotal for developing glia-targeted therapies that are aimed at modulating glial activity in order to ameliorate disease progression and promote neuroprotection in the fight against neurodegenerative diseases.
Dr. Qing Richard Lu
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- neurodegeneration
- oligodendrocytes
- astrocytes
- microglia
- neuroinflammation
- demyelination neuron–glial interactions
- homeostasis
- glia-targeted therapies
