Molecular and Cellular Mechanisms of Liver Regeneration: From Biology to Therapy
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Tissues and Organs".
Deadline for manuscript submissions: 31 March 2025 | Viewed by 104
Special Issue Editor
Interests: liver cell therapy; mesenchymal stem cells; liver regeneration; hepatogenic differentiation; liver defects; cell therapy; liver cell types
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The liver is a critical organ that concomitantly manages complex and vital functions in order to regularly supply the human body with needed nutrients and maintain its homeostasis. Such activities continuously expose the liver to toxic compounds and microorganisms that harm the structure of its parenchyma. In line with its crucial role, the liver displays an astonishing capability of regeneration that efficiently ensures the unremitting execution of its vital functions. However, when regeneration is no longer possible because of several etiological factors, significant and progressive irreversible adverse changes may happen, which chronically hamper liver functionality. Related chronic liver defects are consequently behind a significant increase in mortality, and the gold standard therapeutic approach, orthotopic liver transplantation, is not sufficient to treat all affected patients. Therefore, deep investigations of the molecular and cellular components associated with both physiological and pathological regeneration are of significant interest and should ultimately lead to an understanding of both the different diseases damaging such an organ, which should help in designing appropriate and effective alternative therapeutic solutions.
This Special Issue of Cells welcomes high-quality original basic research papers and reviews that focus on exploring cellular and molecular alterations that drive and hamper both physiological and pathological liver regeneration.
Dr. Mustapha Najimi
Guest Editor
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Keywords
- liver regeneration
- hepatocytes
- chemokines
- growth factors
- liver diseases
- signaling pathways
- inflammation
- liver immunobiology
- fibrosis
- cirrhosis
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