Kidney Organoids: Future Prospects
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: closed (29 February 2024) | Viewed by 278
Special Issue Editor
Interests: reproductive organs; germ cells; epigenetics; metabolism; kidneys
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Human kidney organoids generated from the differentiation of human pluripotent stem cells (iPSCs) give hope to patients needing kidney transplants or under dialysis treatment. Our population is aging, and comorbidity factors (cardiovascular diseases, diabetes type 2, etc.) will impact nephrons and, consequently, kidney functions, leading to chronic kidney diseases. These organoid models, called “mini kidneys”, are essential tools that able us to understand mammalian kidney organogenesis and when diseases occur. We started to more precisely identify how different cells from different compartments interact in kidney organoids and aimed to generate structured, mature, and functional organoids. Challenges still exist in generating these organoids, thus improving scalability, and in precisely defining the matrix where cells are embedded to provide renal regeneration tools in clinical settings.
Prof. Dr. Florence Naillat
Guest Editor
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Keywords
- kidney development
- pluripotent stem cell
- human kidney organoid
- nephron progenitor
- podocyte
- collecting duct
- single-cell transcriptional profiling
- bio-printing
- bioreactor
- extra-cellular matrix (ECM)
