Glioblastoma Horizons: Exploring Mechanisms and Advancing Therapeutic Strategies
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 15 March 2026 | Viewed by 2
Special Issue Editors
Interests: glioblastoma therapy resistance; cancer stem cell; ferroptosis; lipid metabolism
Interests: neurosurgery; neuroimaging
Special Issue Information
Dear Colleagues,
Glioblastoma (GBM), the most aggressive adult brain tumor, is notorious for its high recurrence and mortality rates, with median survival often limited to 12-15 months despite standard therapies like surgery, radiation, and chemotherapy. However, relentless efforts to discover curative approaches continue, driven by groundbreaking advances. Key progress includes innovative immunotherapies such as CAR-T cells delivered via ultrasound to breach the blood–brain barrier, achieving rapid tumor regression in clinical trials and novel personalized vaccines that induce immune memory in preclinical models. Meanwhile, mechanistic studies on GBM's development—elucidating blood-tumor barrier regulation, IDH-wildtype molecular features, and immune evasion pathways—hold profound significance. These insights enhance novel treatment efficacy, promote tumor cell apoptosis, and delay recurrence, paving the way for precision medicine.
This Special Issue will examine novel cell culture models, such as 3D organoids and biomimetic systems, in vivo experimental models including genetically engineered mice and patient-derived xenografts, and methods for drug screening in glioma research. It will also explore the tumor microenvironment together with genetic, epigenetic, and cellular factors driving glioma heterogeneity and its implications for progression and therapeutic resistance. In addition, the Issue will highlight cell models for glioma stem cell differentiation and targeted drug screening, as well as potential mechanisms underlying glioma development, progression, and therapeutic responses.
Dr. Yang Wu
Dr. Julio Plata-Bello
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- glioblastoma heterogeneity
- tumor microenvironment
- 3D cell culture models
- therapeutic resistance mechanisms
- immunotherapy
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