The Roles of CaMKK2 in Cell Metabolism and Disease
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Signaling".
Deadline for manuscript submissions: closed (1 October 2021) | Viewed by 521
Special Issue Editors
2. Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC 3000, Australia
Interests: metabolism; protein structure; kinase; proteomics; cancer; diabetes
Special Issues, Collections and Topics in MDPI journals
2. Exercise and Nutrition Research Program, Mary MacKillop Institute for Health Research, Australian Catholic University, Melbourne, VIC 3000, Australia
3. The Florey Institute of Neuroscience and Mental Health, Parkville, VIC 3052, Australia
Interests: metabolism; kinase regulation; cell signaling; metabolic; neuropsychiatric disorders
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The calcium-sensing enzyme Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) functions as a molecular hub to regulate critical cell functions and physiological responses. CaMKK2’s well-characterised substrates CaMK1, CaMK4, and the metabolic co-ordinator AMP-activated protein kinase (AMPK), implicate CaMKK2 signalling cascades in diverse processes including energy homeostasis, autophagy, cell survival, cell cycle, cytoskeletal remodeling, inflammation, gene expression, mRNA splicing, neuronal excitability, cognition and synaptic plasticity associated with learning and memory. CaMKK2 also directly activates the important oncogenic target AKT (PKB), underpinning recent efforts to develop small-molecule CaMKK2 inhibitors as anti-cancer drugs. In this Special Issue entitled The Roles of CaMKK2 in Cell Metabolism and Disease, we aim to capture the scope of ongoing research being conducted on CaMKK2 at the molecular, cellular and physiological levels. We are particularly interested in submissions investigating how CaMKK2 dysregulation leads to a wide range of pathologies (e.g. cancer, diabetes, osteoporosis) and psychiatric disorders. Our goal is to amalgamate recent advances in this exciting and emerging field, and provide a platform for united commentary on the current state of play regarding the therapeutic potential of CaMKK2.
We look forward to your contributions.
Prof. Jon Oakhill
Dr. John W Scott
Guest Editors
Manuscript Submission Information
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Keywords
- metabolism
- cancer
- appetite regulation
- neuropsychiatric disorders
- signaling
- phosphorylation
- calcium-calmodulin
- kinase inhibitors
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