Role of DNA Repeats in Shaping Genome Structure and Gene Regulatory Networks
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cell Nuclei: Function, Transport and Receptors".
Deadline for manuscript submissions: closed (15 January 2023) | Viewed by 435
Special Issue Editors
Interests: leukemias; breast cancer; chromatin; DNA damage; genomic-instability; metastasis; genomics; mutations
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Repetitive sequences, including transposable elements, and simple repeats constitute at least half of the mouse and human genomes. The most abundant subclasses are the short interspersed nuclear elements (SINEs; 1.4 million copies of human Alu elements or 0,6 millions of mouse B1 repeats) and the long interspersed element-1 (LINE1 or L1; 1.0 million copies in the human and mouse genomes).
Once considered as junk or “parasite” DNA, it is now recognized that repetitive sequences regulate chromatin organization, the 3D structure of the genome, and transcription of specific gene subsets at both transcriptional and post-transcriptional levels. Emerging evidence suggests that their activity influences fundamental cell processes, including inflammation, senescence, genome stability and DNA damage, and is implicated in cancer development and aging.
Topics of interest may include:
- How repetitive sequences shape genome structure and/or gene regulatory networks within their host genome;
- The role of individual repeat subfamilies in gene regulation;
- The role of repetitive sequences in the regulation of fundamental cell processes;
- The role of repetitive sequence in cancer and aging.
Prof. Dr. Pier Giuseppe Pelicci
Dr. Gaetano Ivan Dellino
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- repetitive sequences
- DNA damage
- genome structure
- gene regulatory networks
- cell processes
- cancer and aging
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
