Yeast Stress Responses and Cell Death Regulation
A special issue of Cells (ISSN 2073-4409).
Deadline for manuscript submissions: 15 March 2025 | Viewed by 36
Special Issue Editors
Interests: regulated cell death; mitochondria; ER–mitochondria contact sites; vacuole/lysosomal permeabilization; yeast; metabolism; genome-wide analysis; new compounds; cytotoxicity
Special Issues, Collections and Topics in MDPI journals
Interests: regulated cell death; mitochondrial dysfunctions; cancer/yeast cells; anticancer/antifungal activities; lactoferrin
Special Issues, Collections and Topics in MDPI journals
Interests: cell death; mitochondrial function; microbiology; molecular targets; cancer
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Yeast cells, like all eukaryotic organisms, encounter various environmental stresses that can threaten their survival. These stresses include oxidative stress, heat shock, osmotic stress and nutrient deprivation, among others. In an attempt to recover from these stresses, yeast cells activate a range of adaptive mechanisms to mitigate damage and restore homeostasis. Central to these stress responses are signalling pathways and key regulatory molecules, as well as general defence mechanisms that orchestrate the cellular adjustments needed to withstand adverse conditions.
When the damage is too intense and cannot be overcome, yeasts can induce regulated cell death (RCD). Different gene orthologs of mammalian cell death executors reveal that yeast shares several characteristics with mammalian cell death processes while also exhibiting unique features. Indeed, like mammalian cells, yeast can undergo various RCD processes triggered by different stimuli, primarily classified as apoptotic- or necrotic-RCD, which can be subjected to pharmacologic and genetic inhibition.
Studying these processes in yeast provides valuable insights into the fundamental aspects of cell biology and the evolutionary conservation of stress responses and RCD. This can have impacts on health, providing clues for pharmacological interventions in diseases where these processes are dysregulated, and in biotechnology, potential uncovering targets for the obtention of more robust yeasts for biorefineries.
Prof. Dr. Maria João Sousa
Prof. Dr. Manuela Côrte-Real
Dr. Susana R. Chaves
Guest Editors
Manuscript Submission Information
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Keywords
- yeast stress responses
- environmental stresses
- signalling pathways
- cell death
