Organellar Calcium Signaling in Physiology and Pathophysiology
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Intracellular and Plasma Membranes".
Deadline for manuscript submissions: closed (15 December 2019) | Viewed by 913
Special Issue Editors
Interests: STIM/Orai Ca2+ channels; Transient Receptor Potential (TRP) cation channels
Interests: membrane proteins; ion channels; TRP channels; CFTR channel; cancer; anticancer drugs; mitochondria; lysosomes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Organellar function exists as a tightly regulated network of signalling cascades, each modulating different aspects of cellular physiology, from ATP synthesis to anti-oxidant defence systems and cell death. The function of these organelles is also influenced by the membrane composition and the structural organization and distribution of each organelle within the cell. However, despite the differences in the above-mentioned characteristics, organelles’ mode of action appears similar when they act as Ca2+-buffer and Ca2+-sensor factories. In response to various stimuli, organelles modulate Ca2+ signalling directly by importing Ca2+ via specific proteins embedded in the organellar membranes, or indirectly through the release of metabolites and messengers that can activate the Ca2+ signalling machinery. This intimate relationship between organelles and Ca2+ signalling lays the foundation for cellular decision-making, ultimately influencing cell survival. Therefore, given their importance in maintaining cellular homeostasis, any disturbance in the function of an organelle often results in the development of severe diseases, many of which have yet to be fully understood.
The aim of this Special Issue is to provide an overview summarizing our current knowledge regarding the underlying molecular mechanisms of organellar Ca2+ signalling in the context of normal cell physiology as well as disease, with special focus on the endoplasmic reticulum, lysosomes, and mitochondria.
Prof. Dr. Mohamed Trebak
Dr. Yassine El Hiani
Guest Editors
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Keywords
- organellar Ca2+
- endoplasmic reticulum
- lysosomes
- mitochondria
- peroxisomes
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