Endogenous PCSK9 for Patients with Type 2 Diabetes Mellitus (T2DM)
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".
Deadline for manuscript submissions: closed (20 June 2023) | Viewed by 437
Special Issue Editors
Interests: platelet activation; platelet inhibition; diabetes; obesity; aspirin; oxidative stress
Interests: cancer; aging; diabetes; molecular; osteoporosis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
PCSK9 is a serine protease produced primarily (but not exclusively) by the liver and the intestine that acts as a regulator pathway for hepatic low-density lipoprotein receptor (LDLR) degradation through an endosomal/lysosomal pathway. PCSK9 plays additional roles in atherosclerosis development and progression via a variety of nonclassical mechanisms that involve inflammatory, apoptotic, and immune pathways.
The interplay between lipid and glucose homeostasis and the role of the PCSK9 in glucose metabolism are complex and still unclear. Evidence from epidemiological and genetic studies and clinical trials with PCSK9 inhibitors has led to controversial findings.
Low LDL-C values and/or statin therapy have been associated with the risk of developing T2DM. Mendelian randomization studies have consistently showed that PCSK9 loss-of-function mutations leading to lower LDL-C values were characterized by higher fasting glucose values and higher risk of developing T2DM. In an experimental murine model, PCSK9 deficiency increased LDLR expression and cholesterol ester accumulation in pancreatic islets, which impaired beta cell function and insulin secretion. Conversely, two large randomized double-blind placebo-controlled cardiovascular outcome trials showed that treatment with PCSK9 inhibitors was not associated with increased risk of new onset of diabetes.
In addition, endogenous PCSK9 also plays a role in the cardiovascular complications of patients with diabetes, as highlighted by genetic studies correlating gain‐of‐function and loss-of-function mutations in the PCSK9 gene with coronary artery disease, as well as by the cardiovascular benefit observed with PCSK9-inhibitors.
In this Special Issue of Cells, I invite you to contribute original research articles, reviews, or shorter perspective articles on all aspects related to the title Endogenous PCSK9 for Patients with Type 2 Diabetes Mellitus.
Expert articles describing mechanistic, functional, cellular, biochemical, or general aspects related to the role of endogenous PCSK9 in type 2 diabetes are welcome.
Dr. Francesca Santilli
Dr. Rossella Liani
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- diabetes
- PCSK9
- platelets
- cardiovascular disease
- atherosclerosis
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.
