Kinases in Cancer: Advancing Targeted Therapies and Their Implications in Cancer Immunity
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: 30 March 2025 | Viewed by 82
Special Issue Editors
Interests: tyrosine kinase signaling; adapters and scaffolds in signal transductions; DNA damage response; inflammatory cancer signaling and immunity
2. Molecular Biophysics and Integrated Bioimaging, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
Interests: structural biophysics; precision oncology; cancer bioinformatics; DNA replication; DNA repair
Special Issue Information
Dear Colleagues,
The phospho-modification of amino acids is a powerfully effective way to control cell-fate by dynamically altering protein function based upon environmental changes. Such modifications can act efficiently in response to stress by reversibly changing the local chemistry, forming and disrupting functional protein complexes, and activating signaling cascades. Thus, the human kinome encompasses one of the largest family of proteins that control all aspects of cellular processes from growth, proliferation, and survival to energy production and DNA replication and damage response. The deregulation of kinases themselves or of the adapters and scaffolds within the kinome axis that orchestrates signaling can lead to diseases including malignant transformation and cancer.
In this Special Issue, we will examine kinases and their function in normal and in disease signaling, particularly in cancers and related disorders. Kinases are the most drug-targeted protein family for cancer therapeutics. Yet, we are coming to better understand their regulations and targeting by adaptors and molecular machinery that provide underappreciated targeting opportunities. This Special Issue will therefore also address current information regarding successes, failures, and promising future strategies for kinase targeting. We aim to explore kinase interactome mechanisms, specific inhibitors/approved drugs, and therapeutic impacts on cancer inflammatory signaling extending to potential impact on cancer immunity.
Dr. Zamal Ahmed
Dr. John A. Tainer
Guest Editors
Manuscript Submission Information
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Keywords
- kinase targets
- proliferation
- cell cycle checkpoints
- DNA damage responses
- inflammation
- cancer immune response
- phosphatase targets
- adaptor and scaffold targets
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