Stem Cells and Bone Marrow Transplantation to Cell Immunotherapies
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: closed (15 March 2020) | Viewed by 200
Special Issue Editors
Interests: acute leukemias; cell therapies; chemotherapy; stem cell transplantation
Special Issues, Collections and Topics in MDPI journals
Interests: allogeneic stem cell transplantation; graft versus host disease; T cell therapies; post transplant immune-reconstitution; post-allografting long term complications
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In 1955, by giving mice lethal irradiation and marrow from an H2 incompatible strain, Main and Prehn were able to avoid the rejection of a subsequent skin graft from the same donor strain. It would be later proven that the survival of the graft was due to the persistence of donor cells leading to “tolerance”. These experiments contributed to lay the foundation stone of the currently most established form of cell immunotherapy: bone marrow and stem cell transplantation. In the late 50s, the first attempts to treat hematologic patients with irradiation and intravenous infusion of marrow failed. However, in the mid-70s, the first successful reports in patients with leukemia were reported. Since then, a history of tremendous breakthroughs has unfolded in the field of cell immunotherapy. Recently, genetically engineered T cells with suicide genes and new drugs were employed to modulate severe graft-vs.-host disease or to treat life threatening infections. Moreover, the current wide application of bone marrow transplants from haploidentical donors has dramatically expanded the donor pool. Moving from the platform that stem cell transplantation provided, current advanced technologies have allowed us to successfully redirect T cells against tumor cells by expressing tumor-specific αβ T cell receptor (TCRs) or by engineering autologous and allogeneic chimeric antigen receptor (CAR) T cells against lymphoid cancers. This Special Issue addresses the current applications of bone marrow and stem cell transplantation with the aim of providing an overview of the indications and the areas where future research may improve clinical outcomes. Possible future scenarios with the expansion of disease-specific cell immunotherapies such as CAR T cells will also be presented.
Dr. Benedetto Bruno
Dr. Luisa Giaccone
Guest Editors
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Keywords
- Allogeneic transplantation
- donor selection
- haploidentical transplantation
- Graft-vs.-host disease
- infectious complications
- graft-vs.-leukemia
- CAR-T cells
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