Single-Cell Analysis of Inflammatory Lung-Related Pathologies
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Immunology".
Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 469
Special Issue Editors
Interests: cancer biology; drug development; single cell genomics
Special Issues, Collections and Topics in MDPI journals
Interests: anti-tumor immunity; inflammation and cancer; single cell mass cytometry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Chronic inflammation of the airway tract can emerge under different conditions, leading to life-threatening situations. (i) Tobacco smoking has been described as responsible for 87% of all lung-cancer-related deaths in the USA. Lung cancer is a heterogeneous disease classified by histology into small-cell lung carcinomas (22%) and non-small-cell carcinomas: adenocarcinomas (40%), squamous-cell carcinomas (30%), and large-cell carcinomas (8%). All types are influenced by smoking-related inflammation to different extents. Both cancer cells and the components of the tumor stroma of the lung are of interest. (ii) Smoking, dust, and gases generate inflammation in the airway tract via chronic inflammatory responses to irritants, frequently leading to chronic obstructive pulmonary disease (COPD). COPD and pulmonary fibrosis are the result of ongoing inflammatory processes in the lung, rendering the patient unable to breath. (iii) Irrespective of smoking habits, COVID-19, through the overwhelming immune reaction, fuels lung inflammation that is frequently fatal. We call authors to publish their latest results related to diseases such as lung cancer, COPD, and lung pathologies caused by COVID-19, with a special focus on studies of inflammation using single-cell-resolution technologies. State-of-the-art technologies such as single-cell mass cytometry, single-cell RNAseq, and laser microdissection may reveal unprecedented features of cellular sub-types linking different phenotypes with biological significance. Review articles with clear focuses will also be considered for peer review.
Dr. László G. Puskás
Dr. Gábor J. Szebeni
Guest Editors
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Keywords
- lung cancer
- COPD
- COVID-19
- single-cell proteomics
- single-cell genomics
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