Clinical Cytology

Dear Colleagues,

Following the seminal discovery of stem cells, a wealth of fruitful studies has been realized extremely quickly. These studies have benefited greatly from technological advancement. However, enormous efforts are underway to unravel the molecular mechanisms of fine control for maintaining a normal stem cell reservoir and for regulating proliferation and differentiation (so as to assure normal tissue function). Currently, scientists are carrying out intense research, in parallel and in close collaboration, on perturbations in the molecular processes that lead to disease (e.g., cancer). Major molecular pathways, such as stemness, autophagy, apoptosis, and senescence are implicated with both physiological and pathological roles. Transformative discoveries are opening unexpected insights into intercellular communications, such as exosomes, tunneling nanotubes, etc. These insights help explain the exchange of signals between cells and their role for either maintaining normal or creating abnormal tissue microenvironments.
We encourage researchers to share recent data and reviews, which shed new light on the molecular characteristics of cells in situ of both healthy and diseased tissues.

Dr. Katia Manova-Todorova
Guest Editor

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• Stem cells
• Progenitor cells
• Cancer stem cells
• Proliferation
• Differentiation
• Senescence
• Autophagy
• Apoptosis
• Exosomes
• Tunneling nanotubes