Mammary Stem Cell Reprogramming and Breast Cancer
A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Stem Cells".
Deadline for manuscript submissions: closed (31 May 2022) | Viewed by 620
Special Issue Editor
Interests: molecular pathology of breast cancer; cancer stem cells; mammary stem cells; apoptosis; experimental therapeutics; oncogenes and tumor suppressors; endocrine-disrupting chemicals (EDCs); alcohol and breast cancer; triple negative breast cancer and health disparities; transgenic mouse models
Special Issue Information
Dear Colleagues,
Alterations in mammary development have been associated with modified breast cancer risk for decades. The underlying mechanisms, however, remain unclear. Recent breakthroughs in stem cell technology, functional genomics, and epigenetics have significantly advanced our understanding of the role of mammary stem and progenitor cells in the transition of the critical stages of mammary development, which include prenatal, pre-pubertal, post-pubertal, adult resting gland, pregnancy, lactation, and involution stages. Increasing evidence supports mammary stem/progenitor cells as the cell-of-origin in many breast cancers. In particular, mammary stem and progenitor cells are sensitive to genetic/epigenetic, hormonal, dietary, and environmental factors. The influence from these factors, especially during the critical stages, may “reprogram” mammary development and lead to physiological or tumorigenic consequences. The changes in mammary stem cell repopulation and dynamics are accompanied by the activation of a plethora pathways, such as Wnt and Notch signaling. Therefore, elucidating the mechanism of mammary stem cell reprogramming and identifying the factors that modulate this process are critical to advancing our understanding of breast cancer etiology and developing targeted chemoprevention strategies against breast cancer. To follow the increasing studies on mammary reprogramming, we have organized the current Special Issue to accept original studies, reviews, and technical reports on different aspects of mammary stem cell reprogramming and breast cancer risk. Topics of interest include, but are not limited to, identification of novel markers of mammary stem and progenitor cells; understanding the genetic and epigenetic regulation of mammary stem cells; delineating the signaling pathways in mammary stem cell regulation; perinatal and pubertal exposure to hormonal, dietary, and environmental factors on breast cancer risk later in life; regulation of stemness, such as the epithelial-to-mesenchymal transition (EMT), in mammary stem cell reprogramming; comparative studies of mammary stem cells with human breast cancer stem cells; and regulation of apoptosis and autophagy in glandular remodeling. We expect the reports in this Special Issue to facilitate the “decoding” of mammary stem cell reprograming in development and tumorigenesis, which could be applied to breast cancer prevention and treatment. We are looking forward to your contributions to this Special Issue.
Dr. Xiaohe Yang
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- breast cancer etiology
- mammary stem cells
- mammary reprogramming
- cancer stem cells
- hormonal modulation
- targeted chemoprevention
- EMT
- apoptosis
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue polices can be found here.