Advanced Biosensors for Point-of-Care Testing in Analytical Chemistry

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "(Bio)chemical Sensing".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 418

Special Issue Editors


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Guest Editor
Department of Bioengineering, University of California, Riverside, CA 92521, USA
Interests: point-of-care testing
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Key Laboratory for Processing and Quality Safety Control of Characteristic Agricultural Products, The Ministry of Agriculture and Rural Affairs, Shihezi University, Shihezi 832003, China
Interests: food safety detection

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Guest Editor
State-Key Laboratory of Analog and Mixed-Signal VLSI, Institute of Microelectronics, University of Macau, Macau, China
Interests: microfluidics; biosensors; integrated sensing systems

Special Issue Information

Dear Colleagues,

This Special Issue focuses on the development and application of advanced technology for point-of-care testing (POCT) bacteria, genes, microRNA, protein, metal ions, etc., in analytical chemistry. With the increasing demand for rapid, accurate, and portable diagnostic tools, biosensors have emerged as a key technology for real-time health monitoring and disease diagnosis. This Issue highlights cutting-edge research in biosensor design, including innovative nanomaterials, CRISPR technology, portable devices, lateral flow assays, microfluidics, and the use of nanotechnology to enhance sensitivity and specificity. The goal is to explore how these advancements can be applied to food safety and clinical and environmental settings, enabling efficient and cost-effective diagnostic solutions.

The Special Issue will provide a forum for the latest research activities in the field of POCT-based biosensors. Both review articles and original research papers are solicited in, though not limited to, the following areas:

  • Nanomaterials-based biosensors;
  • POCT biosensors;
  • Portable devices for detection;
  • Microfluidic chip-based biosensors;
  • Lateral flow immunoassays-based biosensors.

Dr. Xiaodong Lin
Dr. Haotian Wu
Dr. Ren Shen
Guest Editors

Manuscript Submission Information

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Keywords

  • biosensors
  • nanomaterials
  • portable detection devices
  • detection
  • point-of-care testing
  • lateral flow assays
  • immunoassay
  • microfluidic chip

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Published Papers (1 paper)

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Research

12 pages, 3153 KiB  
Article
Sensitive Detection of Aflatoxin B1 in Foods Using Aptasensing Based on FGO-Mediated CdTe QDs
by Puye Liang, Sihan Liu, Qinqing Han, Kaixuan Zhou, Tiange Li, Xianqing Huang, Lianjun Song and Tianlin Wang
Chemosensors 2025, 13(4), 141; https://doi.org/10.3390/chemosensors13040141 - 11 Apr 2025
Viewed by 212
Abstract
Aflatoxin B1 (AFB1) exhibits high toxicity and has the potential to induce cancer, deformities, and mutations. It is therefore highly desirable that sensitive and straightforward methods for detecting AFB1 be developed. In this study, due to the high specific [...] Read more.
Aflatoxin B1 (AFB1) exhibits high toxicity and has the potential to induce cancer, deformities, and mutations. It is therefore highly desirable that sensitive and straightforward methods for detecting AFB1 be developed. In this study, due to the high specific adsorption capacity of AFB1 aptamers, we applied a sensing strategy based on quantum dots (QDs) and carboxyl-functionalized graphene oxide (FGO) to construct a simple fluorescence quenching platform. FGO and CdTe QDs modified with AFB1 aptamers cause a FRET effect that produces CdTe QDs with yellow-green fluorescence quenching. When AFB1 is present, aptamers form complexes with it and CdTe QDs leave the quenching platform, resulting in fluorescence recovery. In this study, we used a fluorescence aptasensor with a wide detection range of 0.05 to 150 ng/mL and a low limit of detection (LOD) of 8.2 pg/mL. The average recoveries of AFB1 in peanut and pure milk samples ranged from 94.5% to 107.0%. The aptasensor also exhibited the advantages of simple operation, low cost, and good stability. The sensing strategy reported here can thus serve as a potential candidate for the rapid detection of AFB1. Full article
(This article belongs to the Special Issue Advanced Biosensors for Point-of-Care Testing in Analytical Chemistry)
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