Current Advances in Paediatric Sleep Medicine

A special issue of Children (ISSN 2227-9067). This special issue belongs to the section "Pediatric Pulmonary and Sleep Medicine".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 759

Special Issue Editor


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Guest Editor
Center for Applied Prevention (Zentrum für Angewandte Prävention), Dresden, Germany
Interests: paediatric sleep medicine; differential diagnostics; melatonin; history of medicine

Special Issue Information

Dear Colleagues,

Children with suspected sleep disorders should be referred to a qualified paediatrician, as they perform an important gatekeeper function. We invite you to keep raising awareness of this issue so that the right course can be initiated at an appropriately early time. We welcome current reviews, studies and case descriptions from the fields of child and adolescent psychiatry, paediatric pneumology, otorhinolaryngology, orthodontics, neonatology, genetics, clinical pharmacology, epidemiology, health economics, the history of medicine and other specialist areas.

Prof. Dr. Ekkehart Paditz
Guest Editor

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Keywords

  • paediatric sleep medicine
  • infant sleep
  • adenoidectomy
  • tonsillotomy
  • orthodontic appliances
  • non-hospital ventilation
  • cognitive behavioural therapy
  • melatonin
  • epistemology
  • differential diagnostics

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Published Papers (1 paper)

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30 pages, 2014 KiB  
Systematic Review
Postnatal Development of the Circadian Rhythmicity of Human Pineal Melatonin Synthesis and Secretion (Systematic Review)
by Ekkehart Paditz
Children 2024, 11(10), 1197; https://doi.org/10.3390/children11101197 - 29 Sep 2024
Viewed by 581
Abstract
Introduction: According to current knowledge, at birth, the pineal gland and melatonin receptors are already present and the suprachiasmatic nucleus is largely functional, and noradrenaline, the key pineal transmitter, can be detected in the early foetal period. It is still unclear why the [...] Read more.
Introduction: According to current knowledge, at birth, the pineal gland and melatonin receptors are already present and the suprachiasmatic nucleus is largely functional, and noradrenaline, the key pineal transmitter, can be detected in the early foetal period. It is still unclear why the pineal gland is not able to start its own pulsatile synthesis and secretion of melatonin in the first months of life, and as a result, infants during this time are dependent on an external supply of melatonin. Method: The causes and consequences of this physiological melatonin deficiency in human infancy are examined in a systematic review of the literature, in which 40 of 115 initially selected publications were evaluated in detail. The references of these studies were checked for relevant studies on this topic. References from previous reviews by the author were taken into account. Results: The development and differentiation of the pineal gland, the pinealocytes, as the site of melatonin synthesis, and the development and synaptic coupling of the associated predominantly noradrenergic neural pathways and vessels and the associated Lhx4 homebox only occurs during the first year of life. Discussion: The resulting physiological melatonin deficiency is associated with sleep disorders, infant colic, and increased crying in babies. Intervention studies indicate that this deficiency should be compensated for through breastfeeding, the administration of nonpooled donor milk, or through industrially produced chrononutrition made from nonpooled cow’s milk with melatonin-poor day milk and melatonin-rich night milk. Full article
(This article belongs to the Special Issue Current Advances in Paediatric Sleep Medicine)
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