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Children
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Evaluation of Long-Term Outcomes of Congenital Diaphragmatic Hernia
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Evaluation of Long-Term Outcomes of Congenital Diaphragmatic Hernia

A special issue of Children (ISSN 2227-9067).

Deadline for manuscript submissions: closed (25 September 2022) | Viewed by 7704

Special Issue Editors

Dr. Hanneke IJsselstijn

E-Mail Website
Guest Editor
Department of Pediatric Surgery and Intensive Care, Erasmus MC-Sophia Children's Hospital, 3015 CN Rotterdam, The Netherlands
Interests: congenital diaphragmatic hernia; congenital anatomical malformations; outcome studies; neurodevelopmental outcomes; standardized assessment instruments; quality of life; risk stratification
Dr. Natalie E. Rintoul

E-Mail Website
Guest Editor
Division of Neonatology, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA
Interests: myelomeningocele; pulmonary hypertension; pulmonary hypoplasia; perioperative care of the surgical neonate; ECMO; neonatal resuscitation

Special Issue Information

Dear Colleagues,

As a result of improved prenatal diagnosis, protocolized perinatal care, and implementation of new treatment modalities, more neonates born with Congenital Diaphragmatic Hernia (CDH) now survive. During the past decades, interest has shifted from survival to long-term outcomes. We have learned that, apart from having disease-specific morbidities, children with CDH are at risk for neurodevelopmental problems and failure of educational attainments which may affect their participation in society. International collaboration to develop long-term multidisciplinary follow-up programs for these children is important not only to improve their outcome at an individual level, but also to define universal outcome sets for future intervention trials.

This Special Edition will explore standardized outcomes in children and adolescents with CDH and the availability and validity of multidisciplinary assessment instruments that have been used in this population.

The goal is to provide an update of research in the field of long-term outcomes in CDH and to encourage clinicians to use standardized assessments for follow-up and intervention studies.

Dr. Hanneke IJsselstijn
Dr. Natalie E. Rintoul
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Children is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • congenital diaphragmatic hernia
  • pulmonary imaging
  • neuro-imaging
  • outcome studies
  • neurodevelopmental outcomes
  • standardized assessment instruments
  • proxy-reports
  • self-reports
  • quality of life
  • risk stratification

Published Papers (2 papers)

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Research

13 pages, 669 KiB  
Article
Long-Term Evaluation of Gastroesophageal Reflux in Neonates with and without Preventive Anti-reflux Surgery at the Time of Congenital Diaphragmatic Hernia Repair
by Christoph von Schrottenberg, Susanne Deeg, Christel Weiss, Rüdiger Adam, Lucas M. Wessel, Michael Boettcher and Katrin B. Zahn
Children 2022, 9(8), 1137; https://doi.org/10.3390/children9081137 - 29 Jul 2022
Cited by 3 | Viewed by 1706
Abstract
One potential comorbidity after congenital diaphragmatic hernia (CDH) is gastroesophageal reflux (GER), which can have a substantial effect on patients’ quality of life, thriving, and complications later in life. Efforts have been made to reduce gastroesophageal reflux with a preventive anti-reflux procedure at [...] Read more.
One potential comorbidity after congenital diaphragmatic hernia (CDH) is gastroesophageal reflux (GER), which can have a substantial effect on patients’ quality of life, thriving, and complications later in life. Efforts have been made to reduce gastroesophageal reflux with a preventive anti-reflux procedure at the time of CDH repair. In this follow-up study of neonates participating in a primary RCT study on preventive anti-reflux surgery, symptoms of GER were assessed longitudinally. Long-term data with a median follow-up time of ten years was available in 66 patients. Thirty-one neonates received an initial fundoplication. Secondary anti-reflux surgery was necessary in 18% and only in patients with large defects. It was required significantly more often in patients with intrathoracic herniation of liver (p = 0.015) and stomach (p = 0.019) and patch repair (p = 0.03). Liver herniation was the only independent risk factor identified in multivariate regression analysis. Primary fundopexy and hemifundoplication did not reveal a protective effect regarding the occurrence of GER symptoms, the need for secondary antireflux surgery or the gain of body weight regardless of defect size neither in the short nor in the long term. Symptoms of GER must be assessed carefully especially in children with large defects, as these are prone to require secondary anti-reflux surgery in the long-term. Routine evaluation of GER including endoscopy and impedance measurement should be recommended especially for high-risk patients. Full article
(This article belongs to the Special Issue Evaluation of Long-Term Outcomes of Congenital Diaphragmatic Hernia)
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11 pages, 771 KiB  
Article
Long-Term Outcomes of Congenital Diaphragmatic Hernia: Report of a Multicenter Study in Japan
by Masaya Yamoto, Kouji Nagata, Keita Terui, Masahiro Hayakawa, Hiroomi Okuyama, Shoichiro Amari, Akiko Yokoi, Kouji Masumoto, Tadaharu Okazaki, Noboru Inamura, Katsuaki Toyoshima, Yuhki Koike, Yuta Yazaki, Taizo Furukawa and Noriaki Usui
Children 2022, 9(6), 856; https://doi.org/10.3390/children9060856 - 8 Jun 2022
Cited by 8 | Viewed by 2742
Abstract
Background: Treatment modalities for neonates with congenital diaphragmatic hernia (CDH) have greatly improved in recent years, with a concomitant increase in survival. However, long-term outcomes restrict the identification of optimal care pathways for CDH survivors in adolescence and adulthood. Therefore, we evaluated the [...] Read more.
Background: Treatment modalities for neonates with congenital diaphragmatic hernia (CDH) have greatly improved in recent years, with a concomitant increase in survival. However, long-term outcomes restrict the identification of optimal care pathways for CDH survivors in adolescence and adulthood. Therefore, we evaluated the long-term outcomes within the Japanese CDH Study Group (JCDHSG). Methods: Participants were born with CDH between 2006 and 2018 according to the JCDHSG. Participants were enrolled in the database at 1.5, 3, 6, and 12 years old. Follow-up items included long-term complications, operations for long-term complication, and home medical care. Results: A total of 747 patients were included in this study, with 626 survivors (83.8%) and 121 non-survivors (16.2%). At 1.5, 3, 6, and 12 years old, 45.4%, 36.5%, 34.8%, and 43.6% developed complications, and 20.1%, 14.7%, 11.5%, and 5.1% of participants required home care, respectively. Recurrence, pneumonia, pneumothorax, gastroesophageal reflux disease, and intestinal obstruction decreased with age, and thoracic deformity increased with age. Conclusions: As CDH survival rates improve, there is a need for continued research and fine-tuning of long-term care to optimize appropriate surveillance and long-term follow-up. Full article
(This article belongs to the Special Issue Evaluation of Long-Term Outcomes of Congenital Diaphragmatic Hernia)
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