Crystallization Process and Simulation Calculation, Third Edition

Dear Colleagues,

Following the remarkable success of the first edition and the second edition of this topic, entitled “Crystallization Process and Simulation Calculation” (https://www.mdpi.com/journal/crystals/special_issues/crystallization_process2; https://www.mdpi.com/journal/crystals/special_issues/9LVS3K8K6Q ), we are pleased to announce this third edition.

Crystallization is a crucial unit operation where nucleation, growth, agglomeration, and breakage are regulated to produce high-quality crystals and achieve efficient separation and purification. In recent years, there have been notable advancements in crystallization processes. Process intensification techniques such as ultrasound and wet grinding have been employed to improve the nucleation and breakage processes, thereby preparing ultrafine powders and nanoparticles with different morphologies. Co-crystallization, as a means of crystal engineering, is also widely used to modify crystal structure and morphology, aiming to enhance the physicochemical properties and powder performance of crystal products. Spherical crystallization technology is utilized to generate spherical crystalline particles through crystal growth or agglomeration processes. Continuous crystallization has also gained increasing interest due to its high productivity and consistency in product quality. These studies offer innovative strategies and methods to design processes and control crystallization, ensuring the desired quality attributes and predictable performance of the product. Given the complex nature of crystallization processes, characterized by strong coupling, nonlinearity and large lagging, the challenges that remain include the design of a robust and well-characterized process for efficient crystallization and the production of high-quality crystalline products. The development of process analytical technology that can provide rapid and precise inline or online measurements is critical for designing and controlling crystallization processes. Simulation technology, such as molecular dynamics simulation and hydrodynamics simulation technology, provide insights into the process at multiple scales over time or location. These experimental and simulation tools can greatly enhance the understanding and optimization of crystallization processes.

This Special Issue, “Crystallization Processes and Simulation Calculations, Third Edition”, serves to provide a platform for researchers to report results and findings regarding crystallization process technologies, simulation and process analytical technologies, and relevant crystallization studies.

Dr. Mingyang Chen
Prof. Dr. Jinbo Ouyang
Dr. Kangli Li
Dr. Mengmeng Sun
Dr. Yu Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Crystals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• nucleation and growth
• agglomeration and breakage
• process analytical technology
• process intensification
• continuous crystallization
• spherical crystallization
• co-crystallization
• molecular dynamics simulation
• hydrodynamics simulation

• Crystallization Process and Simulation Calculation in Crystals (12 articles)
• Crystallization Process and Simulation Calculation, Second Edition in Crystals (16 articles)