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Nutrigenetics, Nutrigenomics, and Personalized Nutrition

A special issue of Dietetics (ISSN 2674-0311).

Deadline for manuscript submissions: 15 June 2026 | Viewed by 1178

Special Issue Editors


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Guest Editor
Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
Interests: genetics; proteomics; clinical nutrition; kidney disease; aging; chronic disease

E-Mail Website
Guest Editor
Department of Nutritional Sciences, University of Toronto, Toronto, ON, Canada
Interests: nutrigenetics; nutrigenomics; biomarkers; food preferences; genetic testing; cardiometabolic disease; athletic performance
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Special Issue Information

Dear Colleagues,

The fields of nutrigenetics and nutrigenomics are driving a paradigm shift in nutrition science, providing mechanistic insights into how genetic variation influences nutrient metabolism and how dietary exposures, in turn, modulate gene expression and downstream physiological processes. Together, these disciplines underpin the emerging framework of personalized nutrition, which aims to tailor dietary strategies to individual biological profiles to promote health and prevent disease. The integration of multi-omics platforms, artificial intelligence, and increasingly diverse human populations has further expanded the scope and resolution of this work, accelerating its translational potential.

This Special Issue of Dietetics invites original research articles and reviews that examine the interface between genetic and epigenetic variation, nutritional exposures, and clinically relevant outcomes in human populations. The use of other omics approaches, such as the microbiome, will also be considered. Submissions grounded in mechanistic study designs are especially encouraged, particularly those in which the causal relationship between nutrient intake, genetic variation, and physiological response is articulated and well-supported. We welcome contributions from observational studies, clinical trials, intervention studies, and longitudinal cohorts, as well as investigations of gene–diet interactions, sex- and ancestry-specific responses, and omics-based biomarker discovery.

As computational tools such as AI enhance our ability to interpret complex nutritional and 'omics' datasets, there is a need for rigorous, data-rich, and clinically applicable research that can inform the development of equitable and biologically precise nutrition strategies. This Special Issue aims to bring together contributions from nutrition scientists, omics biologists, clinicians, dietitians, food and data scientists, and clinical epidemiologists working at the forefront of this multidisciplinary field.

Dr. Sara Mahdavi
Dr. Ahmed El-Sohemy
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dietetics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nutrigenetics
  • nutrigenomics
  • precision nutrition
  • personalized nutrition
  • gene–diet interactions
  • multi-omics
  • epigenetics
  • proteomics
  • metabolomics
  • microbiome
  • micronutrient metabolism
  • functional foods and bioactive
  • global nutrition and diversity

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Published Papers (1 paper)

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Review

25 pages, 1143 KB  
Review
Epigenetics, Vitamin Status, Maternal Nutrition, and Fetal Development: A Spotlight on the Importance of Precision Nutrition
by Dalia El Khoury, Haleema Ashraf, Ho Ching Nika Shiu, Sawsan G. A. A. Mohammed, Nader I. Al-Dewik and M. Walid Qoronfleh
Dietetics 2026, 5(2), 19; https://doi.org/10.3390/dietetics5020019 - 26 Mar 2026
Abstract
The reciprocal relationship between genes and nutrients, known as nutrigenetics and nutrigenomics, has been established in many studies. However, current investigations of maternal and neonatal nutrition using a precision nutrition approach focused on genomics are limited, especially in the Middle East and North [...] Read more.
The reciprocal relationship between genes and nutrients, known as nutrigenetics and nutrigenomics, has been established in many studies. However, current investigations of maternal and neonatal nutrition using a precision nutrition approach focused on genomics are limited, especially in the Middle East and North Africa (MENA) region. This review aims to summarize the impacts of the dietary micronutrients, folic acid, thiamine, and cobalamin on optimal health outcomes during pregnancy, fetal development, lactation, and infant growth. In this review, the roles of folic acid, thiamine, and cobalamin are discussed in the context of various aspects of pregnancy, such as preconception, fetal development, and lactation, highlighting how genetic events occurring during developmental periods can have consequential impacts on health outcomes later in life. Deficiency rates and related health consequences as well as the prevalence of genetic mutations related to these nutrients of interest in the MENA region are also elaborated on. How to advance knowledge and applications of precision nutrition, how genes interact with the neurochemical changes during pregnancy, and how this interaction impacts maternal eating behaviors, and consequently fetal development and infant and child growth and health, should be further explored in future studies. This includes taking advantage of cutting-edge technologies and the role of artificial intelligence in this endeavor. Full article
(This article belongs to the Special Issue Nutrigenetics, Nutrigenomics, and Personalized Nutrition)
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