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Recent Therapeutic Advances in Gynecological Diseases and Clinical Management
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Recent Therapeutic Advances in Gynecological Diseases and Clinical Management

A special issue of Diseases (ISSN 2079-9721).

Deadline for manuscript submissions: closed (30 September 2025) | Viewed by 2803

Special Issue Editors

Dr. Mattia Dominoni

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Guest Editor
1. Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy
2. Department of Obstetrics and Gynecology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
Interests: gynecological and obstetrics research
Special Issues, Collections and Topics in MDPI journals
Dr. Barbara Gardella

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Guest Editor
1. Department of Clinical, Surgical, Diagnostic and Paediatric Sciences, University of Pavia, Pavia, Italy
2. Department of Obstetrics and Gynecology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy
Interests: gynecological and obstetrics research
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to this Special Issue about “Recent Therapeutic Advances in Gynecological Diseases and Clinical Management”. The aim of this Special Issue is to collect papers on new proposals in the management and treatment of gynecological disease. Gynecological disorders are classified as a subset of disorders affecting the female reproductive system. Uterine fibroids, female infertility, endometriosis, genital prolapse, premenstrual syndrome, polycystic ovary syndrome, and other benign conditions, such as STDs, fall under this category. Gynecological diseases affect women at every stage of life and are distinguished by their insidious onset, high prevalence, and easy recurrence. Numerous serious consequences, such as infertility, abnormal bleeding, chronic discomfort, urinary issues, and a decline in overall health and quality of life, can result from these disorders. Furthermore, gynecological disorders have a big financial impact. In this Special Issue, original research articles and reviews are welcome.

Research areas may include the following: reproductive age, adolescence, menopause, lower genital tract diseases. 

We look forward to receiving your contributions.

Dr. Mattia Dominoni
Dr. Barbara Gardella
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diseases is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • HPV
  • sexual transmitted diseases
  • lower genital tract
  • menopause
  • obstetrics
  • gynecology
  • epidemiology

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Published Papers (2 papers)

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Research

11 pages, 563 KB  
Article
The Application of Stepwise Pelvic Devascularisation in the Management of Severe Placenta Accreta Spectrum as Part of the Soleymani and Collins Technique for Caesarean Hysterectomy: Surgical Description and Evaluation of Short- and Long-Term Outcomes
by Hooman Soleymani majd, Lamiese Ismail, Prasanna Supramaniam, Aakriti Aggarwal, Annie E. Collins, Lee Lim, Susan Addley, Alicia Hunter, Lexie Pert, Theophilus Adu-Bredu, Pedro Pinto, Ammar Al Naimi, Jacopo Conforti, Karin Fox and Sally L. Collins
Diseases 2025, 13(12), 400; https://doi.org/10.3390/diseases13120400 - 15 Dec 2025
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Abstract
Background: Severe (FIGO grade 3b & c) placenta accreta spectrum (PAS) is potentially a life-threatening condition due to catastrophic haemorrhage at delivery. Consequently, interventional radiology (IR) techniques are often employed to prevent massive blood loss, but this is not always readily available, is [...] Read more.
Background: Severe (FIGO grade 3b & c) placenta accreta spectrum (PAS) is potentially a life-threatening condition due to catastrophic haemorrhage at delivery. Consequently, interventional radiology (IR) techniques are often employed to prevent massive blood loss, but this is not always readily available, is costly, and can cause significant morbidity, including distal limb ischaemia due to thrombus formation. We believe that internal iliac ligation under direct vision is a safe option to control bleeding. We sought to evaluate the short- and long-term outcomes relating to this technique compared to IR. Methods: This is a mixed-methods cohort study of women with severe PAS who underwent hysterectomy with either surgical devascularisation, as part of the Soleymani and Collins (SAC) technique, or IR insertion of internal iliac balloon catheters, in a UK tertiary referral centre for PAS between 2011 and 2022. Only women with intraoperative diagnosis of very severe PAS (FIGO stage 3b & c) were included in this study. Results: Of the 22 women invited to participate in the long-term component of the study, 59% agreed. Women in the surgical devascularisation group experienced no adverse short or late sequelae related to internal iliac arterial ligation. Pelvic devascularisation (11 patients, 41%) demonstrated a reduction in median estimated blood loss, 1600 millilitres vs. 2500 millilitres in the IR balloon catheter group (p = 0.04). Conclusions: We have demonstrated that the SAC technique for surgical devascularisation is a safe method for achieving haemorrhage control during caesarean hysterectomy for severe PAS. It also appears to be at least as effective at haemorrhage control as IR balloon occlusion of the internal iliac vessels. Full article
(This article belongs to the Special Issue Recent Therapeutic Advances in Gynecological Diseases and Clinical Management)
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9 pages, 344 KB  
Article
The Diagnostic Utility of the Triptorelin Stimulation Test Compared to the Standard Gonadotropin-Releasing Hormone Stimulation Test in Children with Idiopathic Central Precocious Puberty
by Giorgio Sodero
Diseases 2025, 13(11), 370; https://doi.org/10.3390/diseases13110370 - 12 Nov 2025
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Abstract
Background: Central precocious puberty (CPP) is diagnosed through a combination of clinical, auxological, and biochemical parameters, with pharmacological stimulation tests considered the diagnostic gold standard. In recent years, triptorelin, a long-acting Gonadotropin-Releasing Hormone (GnRH) analog, has been increasingly adopted in clinical practice due [...] Read more.
Background: Central precocious puberty (CPP) is diagnosed through a combination of clinical, auxological, and biochemical parameters, with pharmacological stimulation tests considered the diagnostic gold standard. In recent years, triptorelin, a long-acting Gonadotropin-Releasing Hormone (GnRH) analog, has been increasingly adopted in clinical practice due to limited availability of native GnRH. Objective: To compare the clinical, auxological, and hormonal profiles of girls diagnosed with idiopathic CPP using either the classical GnRH stimulation test or the triptorelin test. Methods: This retrospective study included 136 female patients diagnosed with CPP and followed for at least two years at a single pediatric endocrinology unit. Of these, 101 underwent a GnRH stimulation test, and 35 were assessed using the triptorelin test. Baseline and stimulated hormonal parameters, growth data, and IGF-1 levels were collected. A multivariate linear regression model was used to explore the influence of age, test type, and other covariates on the LH peak response. Results: Anthropometric and baseline hormonal parameters were comparable between the two groups. The LH peak was significantly higher in the GnRH group (9.8 ± 3.1 IU/L at 60 min) than in the triptorelin group (6.8 ± 2.4 IU/L at 4 h). FSH levels were also significantly lower following triptorelin stimulation (p = 0.004), while the LH/FSH ratio did not differ significantly. Multivariate analysis confirmed that triptorelin was associated with a lower LH peak (β = −2.2, p = 0.008), particularly in younger patients, with a significant interaction between age and test type (β = 0.6, p = 0.022). Conclusions: Both GnRH and triptorelin stimulation tests are valid tools for CPP diagnosis. However, the GnRH test appears to elicit a more robust LH response, especially in younger patients, whereas the triptorelin test is associated with delayed and lower LH peaks. Full article
(This article belongs to the Special Issue Recent Therapeutic Advances in Gynecological Diseases and Clinical Management)
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