Antiviral Drug Discovery and Development: Current Innovations and Future Trends
A special issue of Future Pharmacology (ISSN 2673-9879).
Deadline for manuscript submissions: closed (31 May 2024) | Viewed by 783
Special Issue Editor
Interests: antiviral drug; medicinal chemistry; drug design; new drug modalities
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Infections caused by viruses have been a prominent factor contributing to human mortality since ancient times. Despite the escalating number of antiviral medications approved for clinical use, prolonged usage can readily result in the emergence of drug resistance and adverse effects. The discovery of safe and efficacious antiviral medications is therefore pivotal in the management of viral infections.
Viral infections pose a significant threat to human health. For medicinal chemists, the research and development of antiviral drugs should not only focus on current chronic viral infections such as AIDS and hepatitis B, which are challenging to cure, but should also adopt a strategic vision by targeting potential future virus outbreaks and developing broad-spectrum antiviral drugs. This critical situation necessitates the proficient utilization of classical medicinal strategies for antiviral drug development, and the simultaneously fostering of innovative research paradigms in order to greatly enhance the success rate of such endeavors. This Special Issue warmly welcomes novel research in the field of antiviral drugs.
In this Special Issue, original research articles and reviews are welcome.
Prof. Dr. Peng Zhan
Guest Editor
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Keywords
- antiviral drug discovery
- rational drug design
- phenotypic screening
- structure optimization
- structure–activity relationship
- structural biology
- molecular simulation
- virtual screening
- chemical synthesis
- combinatorial chemistry
- computational chemistry
- molecular hybridization
- scaffold hopping
- bioisosterism
- prodrug
- mechanic-based drug design
- transition state theory
- targeted covalent inhibitors
- substrate envelope
- high-throughput synthesis
- high-throughput protein crystallography
- parallel medicinal chemistry
- spatial-patterned interaction
- multivalent interaction
- molecular tongs
- molecular tweezers
- geometry-matching topography
- membrane-disrupting molecules
- supramolecular drug
- proximity-induced nucleic acid degrader
- proteolysis targeting chimera
- proximity-mediated effects
- sequence-based design
- sub-stoichiometric modulation
- artificial intelligence
- drug resistance
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