Therapeutic Targets for the Treatment of Colorectal Cancer

Dear Colleagues,

Colorectal cancer (CRC) is the second leading cause of cancer mortality, responsible for about 900,000 deaths worldwide annualy. The 5-year survival rate of CRC patients is ~64%, but drops to ~12% for metastatic CRC. Treatment consists of surgery, and is combined with radio-, chemo- and targeted therapy for advanced CRCs. Targeted therapy is directed against proteins that drive tumor growth and progression. The advantage of targeted treatment is its ability to block the growth and spread of cancer cells while limiting damage to healthy cells. Today, therapies targeting EGFR and VEGF, as well as the immune-checkpoints have been approved for CRC treatment, while many more are in clinical or pre-clinical development. This Special Issue will focus on the identification and validation of therapeutic targets for CRC as well as on the development and management of therapeutic approaches for their inhibition. In addition, inovative therapeutic approaches to target currently undrugable proteins, such as synthetic lethality, aptamers, or targeted protein degradation will be discussed.

Dr. Matjaz Rokavec
Guest Editor

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