Next-Generation Hydrogels: Bridging Biology and Engineering for Medical Breakthroughs

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 31 March 2025 | Viewed by 1189

Special Issue Editors


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Guest Editor
Centro de Química Estrutural, Institute of Molecular Sciences, Instituto Superior Técnico, University of Lisbon, 1049-001 Lisboa, Portugal
Interests: hydrogels; controlled drug release; biomaterials characterization; biotribology; adsorption of biomolecules onto biomaterials; sterilization
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Instituto de Engenharia Mecânica (IDMEC), Instituto Superior Técnico, University of Lisbon, 1049-001 Lisbon, Portugal
Interests: biomaterial production and characterization; controlled drug release; mathematical models; surface morphology and topography; mechanical properties; tribology; hydrogels; dental materials; bone cements; ionic liquids; eco-friendly cements

E-Mail Website
Guest Editor
Centro de Química Estrutural (CQE), Institute of Molecular Sciences and Department of Chemical Engineering, Instituto Superior Técnico, University of Lisbon, 1049-001 Lisbon, Portugal
Interests: biomaterial production and characterization; controlled drug release; mathematical models; surface morphology and topography; mechanical properties; tribology; hydrogels; dental materials; bone cements; ionic liquids; eco-friendly cements
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In recent years, hydrogels have attracted considerable attention in the biomedical and pharmaceutical fields due to their unparalleled versatility and functionality. In fact, the similarity of hydrogels to biological tissues due to their high water content, and the possibility of tailoring their properties and enhance cell interactions by choosing specific monomers and synthesis methods have elevated hydrogels to a leading position in biomaterial innovation. This Special Issue, "Next-Generation Hydrogels: Bridging Biology and Engineering for Medical Breakthroughs", seeks to highlight the latest innovations and research in this dynamic field. By integrating biological insights with engineering principles, researchers are developing hydrogels with enhanced properties that address critical challenges in medical applications. Key themes of this Special Issue include, among others, the following:

  • Innovative design and synthesis: Exploration of novel materials and methods for hydrogel production, emphasizing biocompatibility, biodegradability, and functional versatility.
  • Responsive and smart hydrogels: Development of hydrogels capable of responding to environmental stimuli such as pH, temperature, and light, which open new avenues for controlled drug delivery and adaptive tissue scaffolds.
  • Biomedical applications: Applications of hydrogels in areas such as tissue engineering, wound healing, regenerative medicine, and localized drug delivery. Focus on case studies demonstrating significant therapeutic outcomes.
  • Interdisciplinary approaches: Insights from collaborative efforts between biologists, chemists, materials scientists, and engineers to push the boundaries of what hydrogels can achieve in medical science.
  • Future directions and challenges: Discussion of the remaining challenges in hydrogel research, including scalability, regulatory hurdles, and long-term biocompatibility. Exploration of future trends and potential breakthroughs.

This Special Issue aims to provide a comprehensive overview of the current state and future potential of hydrogels in medicine. By bringing together cutting-edge research and fostering interdisciplinary collaboration, we aim to pave the way for new medical breakthroughs that significantly enhance patient care and treatment outcomes, opening up possibilities for personalized medicine and innovative solutions to complex medical challenges. We invite researchers and practitioners to contribute their latest findings and join us in exploring the exciting possibilities that next-generation hydrogels offer.

Dr. Ana Paula Serro
Prof. Dr. Rogério Colaco
Dr. Ana Catarina Branco
Guest Editors

Manuscript Submission Information

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Keywords

  • hydrogels design
  • advanced characterization of materials
  • biomedical applications of hydrogels
  • hydrogel sterilization
  • smart hydrogels
  • biodegradable hydrogels
  • in situ gelation
  • multifunctional hydrogels
  • drug delivery
  • antimicrobial properties

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Published Papers (1 paper)

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25 pages, 4744 KiB  
Article
Tribomechanical Properties of PVA/Nomex® Composite Hydrogels for Articular Cartilage Repair
by Francisco Santos, Carolina Marto-Costa, Ana Catarina Branco, Andreia Sofia Oliveira, Rui Galhano dos Santos, Madalena Salema-Oom, Roberto Leonardo Diaz, Sophie Williams, Rogério Colaço, Célio Figueiredo-Pina and Ana Paula Serro
Gels 2024, 10(8), 514; https://doi.org/10.3390/gels10080514 - 3 Aug 2024
Viewed by 1073
Abstract
Due to the increasing prevalence of articular cartilage diseases and limitations faced by current therapeutic methodologies, there is an unmet need for new materials to replace damaged cartilage. In this work, poly(vinyl alcohol) (PVA) hydrogels were reinforced with different amounts of Nomex® [...] Read more.
Due to the increasing prevalence of articular cartilage diseases and limitations faced by current therapeutic methodologies, there is an unmet need for new materials to replace damaged cartilage. In this work, poly(vinyl alcohol) (PVA) hydrogels were reinforced with different amounts of Nomex® (known for its high mechanical toughness, flexibility, and resilience) and sterilized by gamma irradiation. Samples were studied concerning morphology, chemical structure, thermal behavior, water content, wettability, mechanical properties, and rheological and tribological behavior. Overall, it was found that the incorporation of aramid nanostructures improved the hydrogel’s mechanical performance, likely due to the reinforcement’s intrinsic strength and hydrogen bonding to PVA chains. Additionally, the sterilization of the materials also led to superior mechanical properties, possibly related to the increased crosslinking density through the hydrogen bonding caused by the irradiation. The water content, wettability, and tribological performance of PVA hydrogels were not compromised by either the reinforcement or the sterilization process. The best-performing composite, containing 1.5% wt. of Nomex®, did not induce cytotoxicity in human chondrocytes. Plugs of this hydrogel were inserted in porcine femoral heads and tested in an anatomical hip simulator. No significant changes were observed in the hydrogel or cartilage, demonstrating the material’s potential to be used in cartilage replacement. Full article
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