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Gels
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Hydrogel Surface/Coating for Smart Drug Delivery and Medical Devices
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Hydrogel Surface/Coating for Smart Drug Delivery and Medical Devices

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: closed (20 July 2024) | Viewed by 13521

Special Issue Editors

Dr. Changcan Shi

E-Mail Website
Guest Editor
Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325011, China
Interests: biomaterials; functional polymers; haemostatic materials; tissue engineering; hydrogels
Dr. Xingzhou Peng

E-Mail Website
Guest Editor
School of Biomedical Engineering, Hainan University, Haikou 570228, China
Interests: immunoimaging; cancer nanotherapeutics; biomaterials; tissue engineering; regenerative medicine
Prof. Dr. Yakai Feng

E-Mail Website
Guest Editor
School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China
Interests: hydrogels; biomaterials; functional polymers; gene delivery; drug delivery; tissue engineering; surface modification

Special Issue Information

Dear Colleagues,

In recent decades, the emerging medical platforms based on multifunctional hydrogels have become an alternative approach in targeting therapies and tissue regeneration, owing to the innovative biomaterials. Hydrogels represent one of the most promising implantable materials for on-demand release and artificial surface modification. They can be responsive to and accommodate the microenvironment. The unique soft, gentle, and responsive characteristics endow hydrogels with huge potential in medical application, such as artificial organs, biomedical sensors, drug/gene delivery, and surface modification of medical devices. In particular, functionalized gels with specific chemical linkages and molecules can smartly and precisely release drugs, genes, mRNAs, and vaccines upon specific external stimuli and in the microenvironment.

This Special Issue will provide an overview of the potential strategies to synthesize smart and multifunctional hydrogels for controlled drug delivery, surface coating and further biomedical applications. Original research, review, and perspective articles related to the specified subject are welcome. These subject areas include, but are not limited to:

  • Development of multifunctional hydrogels for drug, gene, RNA, and protein delivery for cancer diagnosis and treatment, tissue vascularization and regeneration, and genetic-disease treatment.
  • Hydrogel surface and coating for medical devices.

Dr. Changcan Shi
Dr. Xingzhou Peng
Prof. Dr. Yakai Feng
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • hydrogel
  • drug delivery
  • medical devices
  • surface
  • responsive
  • tissue engineering

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Published Papers (6 papers)

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Editorial

Jump to: Research, Review

2 pages, 137 KiB  
Editorial
Hydrogel Surface/Coating for Smart Drug Delivery and Medical Devices
by Changcan Shi, Xingzhou Peng and Yakai Feng
Gels 2024, 10(9), 592; https://doi.org/10.3390/gels10090592 - 13 Sep 2024
Viewed by 1026
Abstract
In recent years, multifunctional hydrogels have been used to develop emerging medical platforms and become an alternative approach in targeting therapies and tissue regeneration [...] Full article
(This article belongs to the Special Issue Hydrogel Surface/Coating for Smart Drug Delivery and Medical Devices)

Research

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15 pages, 14891 KiB  
Article
Tissue Reaction to Low-Density Polyacrylamide Gel as a Carrier for Microimplants in the Adipose Fin of Rainbow Trout
by Ekaterina Borvinskaya, Svetlana Matrosova, Irina Sukhovskaya, Polina Drozdova, Evgeniy Titov, Inna Anikienko, Yulia Lubyaga, Anton Gurkov and Maxim Timofeyev
Gels 2023, 9(8), 629; https://doi.org/10.3390/gels9080629 - 5 Aug 2023
Cited by 1 | Viewed by 1755
Abstract
The implantation of optical sensors is a promising method for monitoring physiological parameters of organisms in vivo. For this, suitable hydrogels are required that can provide a biocompatible interface with the organism’s tissues. Amorphous hydrogel is advantageous for administration in animal organs due [...] Read more.
The implantation of optical sensors is a promising method for monitoring physiological parameters of organisms in vivo. For this, suitable hydrogels are required that can provide a biocompatible interface with the organism’s tissues. Amorphous hydrogel is advantageous for administration in animal organs due to its ease of injection compared to resilient analogs. In this study, we investigated the applicability of a semi-liquid 2.5% polyacrylamide hydrogel (PAAH) as a scaffold for fluorescent polyelectrolyte microcapsules (PMs) in rainbow trout. The hydrogel was injected subcutaneously into the adipose fin, which is a small, highly translucent fold of skin in salmonids that is convenient for implanting optical sensors. Using histological methods, we compared tissue organization and in vivo stability of the applied hydrogel at the injection site after administration of uncoated PMs or PMs coated with 2.5% PAAH (PMs-PAAH) for a period of 3 to 14 days. Our results showed that the introduction of PMs into the gel did not have a masking effect, as they were recognized, engulfed, and carried away by phagocytes from the injection site. However, both PMs and PMs-PAAH were found to provoke chronic inflammation at the injection site, although according to cytokine expression in the fish spleen, the irritating effect was local and did not affect the systemic immunity of the fish. Therefore, our study suggests low applicability of 2.5% polyacrylamide as a scaffold for injectable sensors within a timeframe of days. Full article
(This article belongs to the Special Issue Hydrogel Surface/Coating for Smart Drug Delivery and Medical Devices)
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14 pages, 3326 KiB  
Article
Controlled Release of Growth Factor from Heparin Embedded Poly(aldehyde guluronate) Hydrogels and Its Effect on Vascularization
by Yilan Zhao, Zezhong Lin, Wenqu Liu, Mingwei Piao, Junjie Li and Hong Zhang
Gels 2023, 9(7), 589; https://doi.org/10.3390/gels9070589 - 21 Jul 2023
Cited by 2 | Viewed by 1579
Abstract
To deliver growth factors controllably for tissue regeneration, poly(aldehyde guluronate) (PAG) was obtained from alginate and covalently cross-linked with aminated gelatin (AG) to form PAG/AG hydrogel as a growth factors carrier. The prepared hydrogel exhibits a slow degradation rate and excellent cytocompatibility. Heparin [...] Read more.
To deliver growth factors controllably for tissue regeneration, poly(aldehyde guluronate) (PAG) was obtained from alginate and covalently cross-linked with aminated gelatin (AG) to form PAG/AG hydrogel as a growth factors carrier. The prepared hydrogel exhibits a slow degradation rate and excellent cytocompatibility. Heparin was conjugated with gelatin and embedded into the hydrogel to reserve and stabilize growth factors. Basic fibroblast growth factor (bFGF) was immobilized into the hydrogel and performed sustained release as the hydrogel degraded. The bFGF loaded hydrogel can improve vascularization effectively in a rat dorsal sac model. To summarize, heparin embedded PAG/AG hydrogels would serve as a promising biodegradable vehicle for the controlled delivery of growth factors and promoting vascularization in regenerative medicine. Full article
(This article belongs to the Special Issue Hydrogel Surface/Coating for Smart Drug Delivery and Medical Devices)
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Graphical abstract

13 pages, 4886 KiB  
Article
Smart-Temporary-Film-Based Local-Delivery System with Controllable Drug-Release Behavior
by Denghang Xie, Huiwen Wang, Cheng Yin, Mengxia Peng, Haiyong Ao, Jian Hu, Yizao Wan and Quanchao Zhang
Gels 2022, 8(12), 773; https://doi.org/10.3390/gels8120773 - 27 Nov 2022
Cited by 1 | Viewed by 1627
Abstract
The development of a simple local drug-delivery system that exhibits the advantages of macro- and microscale carriers with controllable drug-release behavior is still highly desired. Herein, in this work, a smart temporary film was prepared from doxorubicin (DOX)-loaded shape-memory microgels via a simple [...] Read more.
The development of a simple local drug-delivery system that exhibits the advantages of macro- and microscale carriers with controllable drug-release behavior is still highly desired. Herein, in this work, a smart temporary film was prepared from doxorubicin (DOX)-loaded shape-memory microgels via a simple hot-compression programming method. The temporary film showed a very smooth surface and easy handing, as well as macroscopy mechanical properties, which could disintegrate into the microgels with heating at 45 °C. In this case, the temporary film showed a controllable DOX release behavior when compared with the microgels, which could release the DOX on demand. Consequently, the temporary film exhibited weaker cytotoxicity to normal cells and a much longer antitumor capability, as well as a higher drug-utilization efficiency when compared with microgels. Therefore, the smart temporary film has high potential as a candidate for use as a local drug-delivery system. Full article
(This article belongs to the Special Issue Hydrogel Surface/Coating for Smart Drug Delivery and Medical Devices)
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Review

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22 pages, 5808 KiB  
Review
Lubricating Polymer Gels/Coatings: Syntheses and Measurement Strategies
by Panpan Zhao and Jacob Klein
Gels 2024, 10(6), 407; https://doi.org/10.3390/gels10060407 - 19 Jun 2024
Cited by 2 | Viewed by 2016
Abstract
Straightforward design and long-term functionality for tribological considerations has prompted an extensive substitution of polymers for metals across various applications, from industrial machinery to medical devices. Lubrication of and by polymer gels/coatings, essential for ensuring the cost-effective operation and reliability of applications, has [...] Read more.
Straightforward design and long-term functionality for tribological considerations has prompted an extensive substitution of polymers for metals across various applications, from industrial machinery to medical devices. Lubrication of and by polymer gels/coatings, essential for ensuring the cost-effective operation and reliability of applications, has gained strong momentum by benefiting from the structural characteristics of natural lubrication systems (such as articular cartilage). The optimal synthetic strategy for lubricating polymer gels/coatings would be a holistic approach, wherein the lubrication mechanism in relation to the structural properties offers a pathway to design tailor-made materials. This review considers recent synthesis strategies for creating lubricating polymer gels/coatings from the molecular level (including polymer brushes, loops, microgels, and hydrogels), and assessing their frictional properties, as well as considering the underlying mechanism of their lubrication. Full article
(This article belongs to the Special Issue Hydrogel Surface/Coating for Smart Drug Delivery and Medical Devices)
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38 pages, 5638 KiB  
Review
Chitosan Hydrogel as Tissue Engineering Scaffolds for Vascular Regeneration Applications
by Qiulin Wang, Xiaoyu Wang and Yakai Feng
Gels 2023, 9(5), 373; https://doi.org/10.3390/gels9050373 - 1 May 2023
Cited by 33 | Viewed by 4335
Abstract
Chitosan hydrogels have a wide range of applications in tissue engineering scaffolds, mainly due to the advantages of their chemical and physical properties. This review focuses on the application of chitosan hydrogels in tissue engineering scaffolds for vascular regeneration. We have mainly introduced [...] Read more.
Chitosan hydrogels have a wide range of applications in tissue engineering scaffolds, mainly due to the advantages of their chemical and physical properties. This review focuses on the application of chitosan hydrogels in tissue engineering scaffolds for vascular regeneration. We have mainly introduced these following aspects: advantages and progress of chitosan hydrogels in vascular regeneration hydrogels and the modification of chitosan hydrogels to improve the application in vascular regeneration. Finally, this paper discusses the prospects of chitosan hydrogels for vascular regeneration. Full article
(This article belongs to the Special Issue Hydrogel Surface/Coating for Smart Drug Delivery and Medical Devices)
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