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Gels
Special Issues
Hydrogels for Biomedical Applications: New Sight
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Hydrogels for Biomedical Applications: New Sight

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: closed (30 September 2024) | Viewed by 792

Special Issue Editor

Dr. Céline Valéry

E-Mail Website
Guest Editor
School of Health and Biomedical Science, RMIT University, Victoria 3083, Australia
Interests: amyloid; peptide self-assembly; nanostructure; bionanotechnology; hydrogels

Special Issue Information

Dear Colleagues,

Since the first biological application of hydrogels appeared in 1960, they have become an increasingly popular biomaterial. Today, there is a trend towards utilizing hydrogels as an interdisciplinary bridge across various biomedical fields, including pharmaceutical drug delivery, clinical therapies, surgeries, cosmetics, marketed products, and many more.

This Special Issue aims to provide an overview of groundbreaking research related to hydrogels and their most relevant applications in biomedicine, and hopes to highlight the current and future state of biomedical hydrogel research. We hope that this Special Issue will provide the scientific community with novel insights regarding this ever-expanding field of research.

Dr. Céline Valéry
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Gels is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomaterials
  • hydrogels
  • amyloid
  • peptide self-assembly
  • brain peptides
  • bionanotechnology

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Published Papers (1 paper)

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Research

11 pages, 250 KiB  
Article
Antibiotic-Loaded Hydrogel for the Treatment of Lower-Limb Fracture-Related Infections: A Single Center’s Multidisciplinary Experience
by Daniele De Meo, Paolo Martini, Federico Lo Torto, Flavia Petrucci, Jessica Ordonez Reyna, Vittorio Candela, Giancarlo Iaiani, Alessandra Oliva, Diego Ribuffo and Stefano Gumina
Gels 2024, 10(10), 628; https://doi.org/10.3390/gels10100628 - 29 Sep 2024
Viewed by 536
Abstract
A fracture-related infection (FRI) is a severe complication of an orthopedic trauma, often leading to challenging treatments and poor outcomes. The surgical strategies are typically categorized into one-stage or two-stage procedures, with the use of systemic and local antibiotics being crucial for infection [...] Read more.
A fracture-related infection (FRI) is a severe complication of an orthopedic trauma, often leading to challenging treatments and poor outcomes. The surgical strategies are typically categorized into one-stage or two-stage procedures, with the use of systemic and local antibiotics being crucial for infection management. This study assessed the efficacy of an antibiotic-loaded hydrogel (ALH) applied over the internal fixation devices for treating FRIs, comparing the outcomes between the one-stage (OS) and two-stage (TS) reconstructions. This retrospective study included 17 patients with an FRI treated using the ALH at a single center. The patients were divided into OS and TS reconstruction groups. The data on demographics, surgical procedures, antibiotic regimens, and outcomes were collected. The primary and secondary outcomes included the infection cure rate, bone union, complications, and reoperation rates. Among the 17 patients (mean age 48.5 years, 16 males), infections were predominantly in the tibia, with 12 chronic and 5 acute cases. Seven patients had monomicrobial infections, and nine had multidrug-resistant pathogens. No significant differences were found between the OS and TS groups in terms of the infection cure rate, bone union, or complications. One patient in the OS group experienced an infection recurrence, and bone healing was achieved in all but one case. Additional complications included delayed wound closure in two cases and implant failure in one case, requiring a reoperation. The ALH demonstrated potential as an effective local antibiotic treatment for FRIs, particularly in the one-stage reconstructions, allowing for a safe application of internal fixation devices. However, further research with larger sample sizes and longer follow-ups is needed to validate these findings. Full article
(This article belongs to the Special Issue Hydrogels for Biomedical Applications: New Sight)
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