Preparation and Functionalization of Nano-Cellulose Aerogel

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Processing and Engineering".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 2501

Special Issue Editor


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Guest Editor
College of Textile Science and Engineering, Zhejiang Sci-Tech University, Xiasha Higher Education Park Avenue 2 No.928, Hangzhou 310018, China
Interests: nanocellulose; aerogel; hydrogel; stimuli-responsive polymers; atmospheric drying

Special Issue Information

Dear Colleagues,

One of the most significant research topics for the development of sustainable chemistry is realizing the high-value use of biomass resources. Because of its high porosity, low density, and biodegradability, nano-cellulose aerogel holds a lot of promise in the areas of thermal insulation, catalyst carrier, and environmental remediation, etc. As a result, comprehending how to prepare cellulose aerogels efficiently and inexpensively, regulating the microstructure of cellulose aerogels, and achieve the functionalization of cellulose aerogels are critical for boosting the use of biomass resources.

Dr. Yingzhan Li
Guest Editor

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Keywords

  • Nanocellulose
  • Aerogel
  • Hydrogel
  • atmospheric drying
  • Microstructural regulation

Published Papers (1 paper)

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Research

13 pages, 3104 KiB  
Article
In Vivo Effect of Resveratrol-Cellulose Aerogel Drug Delivery System to Relieve Inflammation on Sports Osteoarthritis
by Ningxin Cui, Zhen Xu, Xinyu Zhao, Meng Yuan, Leiyu Pan, Tianfeng Lu, Ai Du and Lili Qin
Gels 2022, 8(9), 544; https://doi.org/10.3390/gels8090544 - 29 Aug 2022
Cited by 8 | Viewed by 2125
Abstract
Resveratrol (Res) is a plant extract with strong anti-inflammatory, antioxidant and anti-aging biological activities. However, Res is limited by its disadvantages, such as poor solubility, rapid metabolism and low bioavailability. In this study, the Resveratrol-loaded TEMPO-oxidized cellulose aerogel (RLTA) drug delivery system was [...] Read more.
Resveratrol (Res) is a plant extract with strong anti-inflammatory, antioxidant and anti-aging biological activities. However, Res is limited by its disadvantages, such as poor solubility, rapid metabolism and low bioavailability. In this study, the Resveratrol-loaded TEMPO-oxidized cellulose aerogel (RLTA) drug delivery system was prepared by the method of “dissolution-freeze-drying” and characterized by a series of analysis. Then the blood biochemical indexes and HE staining were measured and analyzed in animal experiments. The in vivo results showed that RLTA can decrease the levels of TNF-α and IL-6 inflammatory factors in the synovial fluid. Furthermore, the molecular mechanism was investigated through the analysis of silent information regulator 2 homolog 1 (Sirt1) protein expression, which suggested that RLTA could upregulate the expression of Sirt1 and mediate the P38 signaling pathway, thereby inhibiting the expression of COX-2 and MMP13 which can suppress the levels of IL-6 and TNF-α inflammatory factor. These results reveal that cellulose aerogel is a promising candidate for drug delivery and RLTA has great potential application for the treatment of sports osteoarthritis. Full article
(This article belongs to the Special Issue Preparation and Functionalization of Nano-Cellulose Aerogel)
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