Development of Nanogels/Microgels for Regenerative Medicine

A special issue of Gels (ISSN 2310-2861). This special issue belongs to the section "Gel Applications".

Deadline for manuscript submissions: 31 December 2024 | Viewed by 3344

Special Issue Editors


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Guest Editor
Department of Immunology, Kyoto Prefectural University of Medicine, Kyōto 602-8566, Japan
Interests: regenerative medicine; immunology; cell reprogramming

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Guest Editor
Department of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA
Interests: biomaterials; tissue engineering and regenerative medicine; organ-on-a-chip

Special Issue Information

Dear Colleagues,

In recent years, enormous growth in nano-material technology and science has been attained in the biomedical filed. For example, nanosized hydrogels, so-called nanogels, have been reported to provide a feasible drug-delivery system that enables the efficient transfer of chemotherapeutics and short interfering RNA, and slow-release anti-bacterial peptide, growth factors and cytokines on-site. Through the functions, nanogels can inhibit tumor growth, and enhance wound-healing and blood vessel regeneration. Moreover, nanogels are also used as a scaffold for tissue engineering, including bone, cardiac and urethra tissue regeneration. In general, nanogels are highly biocompatible and biodegradable. Nanogels are also considered to be excellent scaffolds for preparing composites as a novel class of advanced materials, which comprise both nanogels and other constituents, such as polymers or inorganic nanoparticles. Thus, the development of nanogels and their effective application will play an important role in the regenerative medicine field.

This Special Issue will provide various reports on the leading edge nanogels’ synthesis and their effective application in regenerative medicine.

Dr. Kenta Yamamoto
Dr. Yuanhui Song
Guest Editors

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Keywords

  • nanogels
  • regenerative medicine
  • gel application
  • medical field
  • RNAi transfer
  • growth factor release
  • biomedical scaffolds

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Published Papers (2 papers)

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Research

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18 pages, 9457 KiB  
Article
Novel Injectable Collagen/Glycerol/Pullulan Gel Promotes Osteogenic Differentiation of Mesenchymal Stem Cells and the Repair of Rat Cranial Defects
by Xin Wang, Satoshi Komasa, Yoshiro Tahara, Shihoko Inui, Michiaki Matsumoto and Kenji Maekawa
Gels 2024, 10(12), 775; https://doi.org/10.3390/gels10120775 - 28 Nov 2024
Viewed by 359
Abstract
Bone tissue engineering is a technique that simulates the bone tissue microenvironment by utilizing cells, tissue scaffolds, and growth factors. The collagen hydrogel is a three-dimensional network bionic material that has properties and structures comparable to those of the extracellular matrix (ECM), making [...] Read more.
Bone tissue engineering is a technique that simulates the bone tissue microenvironment by utilizing cells, tissue scaffolds, and growth factors. The collagen hydrogel is a three-dimensional network bionic material that has properties and structures comparable to those of the extracellular matrix (ECM), making it an ideal scaffold and drug delivery system for tissue engineering. The clinical applications of this material are restricted due to its low mechanical strength. In this investigation, a collagen-based gel (atelocollagen/glycerol/pullulan [Col/Gly/Pul] gel) that is moldable and injectable with high adhesive qualities was created by employing a straightforward technique that involved the introduction of Gly and Pul. This study aimed to characterize the internal morphology and chemical composition of the Col/Gly/Pul gel, as well as to verify its osteogenic properties through in vivo and in vitro experiments. When compared to a standard pure Col hydrogel, this material is more adaptable to the complexity of the local environment of bone defects and the apposition of irregularly shaped flaws due to its greater mechanical strength, injectability, and moldability. Overall, the Col/Gly/Pul gel is an implant that shows great potential for the treatment of complex bone defects and the enhancement of bone regeneration. Full article
(This article belongs to the Special Issue Development of Nanogels/Microgels for Regenerative Medicine)
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Review

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16 pages, 2389 KiB  
Review
Cholesterol-Bearing Polysaccharide-Based Nanogels for Development of Novel Immunotherapy and Regenerative Medicine
by Tetsuya Adachi, Yoshiro Tahara, Kenta Yamamoto, Toshiro Yamamoto, Narisato Kanamura, Kazunari Akiyoshi and Osam Mazda
Gels 2024, 10(3), 206; https://doi.org/10.3390/gels10030206 - 18 Mar 2024
Cited by 1 | Viewed by 2051
Abstract
Novel functional biomaterials are expected to bring about breakthroughs in developing immunotherapy and regenerative medicine through their application as drug delivery systems and scaffolds. Nanogels are defined as nanoparticles with a particle size of 100 nm or less and as having a gel [...] Read more.
Novel functional biomaterials are expected to bring about breakthroughs in developing immunotherapy and regenerative medicine through their application as drug delivery systems and scaffolds. Nanogels are defined as nanoparticles with a particle size of 100 nm or less and as having a gel structure. Nanogels have a three-dimensional network structure of cross-linked polymer chains, which have a high water content, a volume phase transition much faster than that of a macrogel, and a quick response to external stimuli. As it is possible to transmit substances according to the three-dimensional mesh size of the gel, a major feature is that relatively large substances, such as proteins and nucleic acids, can be taken into the gel. Furthermore, by organizing nanogels as a building block, they can be applied as a scaffold material for tissue regeneration. This review provides a brief overview of the current developments in nanogels in general, especially drug delivery, therapeutic applications, and tissue engineering. In particular, polysaccharide-based nanogels are interesting because they have excellent complexation properties and are highly biocompatible. Full article
(This article belongs to the Special Issue Development of Nanogels/Microgels for Regenerative Medicine)
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